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The Role of Calcium, Magnesium, and Zinc in Pre-Eclampsia

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Abstract

Pre-eclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Its exact etiology is not known, although several evidences indicate that various elements might play an important role in pre-eclampsia. This study was carried out to analyze and to compare the concentration of calcium, magnesium, and zinc in the serum of women with pre-eclampsia and in normal pregnant women. Fifty clinically diagnosed patients with pre-eclampsia (25 with mild and 25 with severe pre-eclampsia) and 50 normal pregnant controls were enrolled in this study. The serum calcium, magnesium, and zinc levels were estimated with an atomic absorption spectrophotometer. The mean serum levels of calcium, magnesium, and zinc in normal pregnant group were 2.45 ± 0.18 mmol/L, 0.79 ± 0.13 mmol/L, and 15.64 ± 2.4 µmol/L, respectively, while in mild pre-eclamptic group, these were 2.12 ± 0.15 mmol/L, 0.67 ± 0.14 mmol/L, and 12.72 ± 1.7 µmol/L, respectively. Serum levels in severe pre-eclamptic group were 1.94 ± 0.09 mmol/L, 0.62 ± 0.11 mmol/L, and 12.04 ± 1.4 µmol/L, respectively. These results indicate that reduction in serum levels of calcium, magnesium, and zinc during pregnancy might be possible contributors in etiology of pre-eclampsia, and supplementation of these elements to diet may be of value to prevent pre-eclampsia.

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References

  1. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD (2005) Hypertensive disorders in pregnancy. In: Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD (eds) Williams obstetrics, 22nd edn. McGraw-Hill, New York, pp 761–808

    Google Scholar 

  2. Vasiljevic N, Vasiljevic M, Plecas D (1996) Role of nutritional factors in pre-eclampsia and eclampsia. Srp Arh Celok Lek 124:156–159

    CAS  PubMed  Google Scholar 

  3. Motghare VM, Faruqui AA, Dudhgaonkar S, Purwar M (2003) Pharmacotherapy of hypertension in pregnancy: a review. Obstet Gynecol 8:541–549

    Google Scholar 

  4. Newman V, Fullerton TT (1990) Role of nutrition in the prevention of pre-eclampsia. J Nurse Midwifery 35:282–291

    Article  CAS  PubMed  Google Scholar 

  5. Sibai BM (1998) Prevention of pre-eclampsia; a big disappointment. Am J Obstet Gynaecol 179:1275–1278

    Article  CAS  Google Scholar 

  6. Raman L, Shatrugna V (2002) Nutrition during pregnancy and lactation. In: Mahtab SB, Prahlad Rao N, Vinodini R (eds) Textbook of human nutrition. IBH, New Delhi, p 509

    Google Scholar 

  7. Pathak P, Kapil U (2004) Role of trace elements zinc, copper and magnesium during pregnancy and its outcome. Indian J Pediatr 71:1003–1005

    Article  PubMed  Google Scholar 

  8. Wynn A, Wynn M (1988) Magnesium and other nutrients deficiencies as possible causes of hypertension and low birth weight. Nutr health 6:69–88

    CAS  PubMed  Google Scholar 

  9. Deborah M (2000) Role of nutrition in prevention of toxemia. Am J Clin Nutr 72:S298–S300

    Google Scholar 

  10. Belizan JM, Villar J (1980) The relationship between calcium intake and edema, proteinuria and hypertension-gestosis: a hypothesis. Am J Clin Nutr 33:2202–2210

    CAS  PubMed  Google Scholar 

  11. Hamlin RH (1952) The prevention of eclampsia and pre-eclampsia. Lancet 1:64–68

    Article  CAS  PubMed  Google Scholar 

  12. Villar J, Belizan JM, Fischer PJ (1983) Epidemiologic observations on the relationship between calcium intake and eclampsia. Int J Gynaecol Obstet 21:271–278

    Article  CAS  PubMed  Google Scholar 

  13. Belizan JM, Villar J, Repke J (1988) The relationship between calcium intake and pregnancy-induced hypertension: up-to-date evidence. Am J Obstet Gynecol 158:898–902

    CAS  PubMed  Google Scholar 

  14. Kumru S, Aydin S, Simsek M, Sahin K, Yaman M, Ay G (2003) Comparison of serum copper, zinc, calcium, and magnesium levels in pre-eclamptic and healthy pregnant women. Biol Trace Elem Res 94:105–112

    Article  CAS  PubMed  Google Scholar 

  15. Kazerooni T, Hamze-Nejadi S (2003) Calcium to creatinine ratio in a spot sample of urine for early prediction of pre-eclampsia. Int J Gynaecol Obstet 80:279–283

    Article  CAS  PubMed  Google Scholar 

  16. Duvekot EJ, DeGroot CJ, Bloemenkamp KW, Oei SG (2002) Pregnant women with a low milk intake have an increased risk of developing pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 105:11–14

    Article  PubMed  Google Scholar 

  17. Sarma PC, Gambhir SS (1995) Therapeutic uses of magnesium. Indian J Pharmacol 27:7–13

    Google Scholar 

  18. Doyle W, Crawford MA, Wynn AH, Wynn SW (1989) Maternal magnesium intake and pregnancy outcome. Magnes Res 2:205–210

    CAS  PubMed  Google Scholar 

  19. Touyz RM (2003) Role of magnesium in pathogenesis of hypertension. Mol Aspects Med 24:107–136

    Article  CAS  PubMed  Google Scholar 

  20. King JC (2000) Determinants of maternal zinc status during pregnancy. Am J Clin Nutr 71:S1334–S1343

    Google Scholar 

  21. Muller O, Krawinkel M (2005) Malnutrition and health in developing countries. CMAJ 173:279–286

    PubMed  Google Scholar 

  22. Gibson RS (1994) Zinc nutrition in developing countries. Nutr Res Rev 7:151–173

    Article  CAS  PubMed  Google Scholar 

  23. Black RE (2001) Micronutrients in pregnancy. Br J Nutr 85:S193–S197

    Article  CAS  PubMed  Google Scholar 

  24. Christian P (2003) Micronutrients and reproductive health issues: an international perspective. J Nutr 133:S1969–S1973

    Google Scholar 

  25. Picciano MF (2003) Pregnancy and lactation: physiological adjustments, nutritional requirements and the role of dietary supplements. J Nutr 133:S1997–S2002

    Google Scholar 

  26. LA YasodharaP R, Raman L (1991) Trace minerals in pregnancy.1.Copper and zinc. Nutr Res 11:15–21

    Article  Google Scholar 

  27. Mahomed K, Williams MA, Woelk GB, Mudzamiri S, Madzime S, King IB, Bankson DD (2000) Leukocyte selenium, zinc, and copper concentrations in pre-eclamptic and normotensive pregnant women. Biol Trace Elem Res 75:107–118

    Article  CAS  PubMed  Google Scholar 

  28. Prasad AS (1985) Clinical manifestations of zinc deficiency. Ann Rev Nutr 5:341–363

    Article  CAS  Google Scholar 

  29. Jameson S (1993) Zinc status in pregnancy: the effect of zinc therapy on perinatal mortality, prematurity, and placental ablation. Ann N Y Acad Sci 678:178–192

    Article  CAS  PubMed  Google Scholar 

  30. Chien PF, Khan KS, Arnott N (1996) Magnesium sulphate in the treatment of eclampsia and pre-eclampsia: an overview of the evidence from randomised trials. Br J Obstet Gynaecol 103:1085–1091

    CAS  PubMed  Google Scholar 

  31. Friedman PA (2006) Agents affecting mineral ion homeostasis and bone turnover. In: Brunton LL, Lazo JS, Parker KL (eds) Goodman and Gillman’s. The pharmacological basis of therapeutics, 11th edn. Mc Graw-Hill, New York

    Google Scholar 

  32. Osendrep SJM, West SE, Black RE (2003) The need for maternal zinc supplementation in developing countries. J Nutr 133:S817–S827

    Google Scholar 

  33. Adam B, Malatyalioglu E, Alvur M, Talu C (2001) Magnesium, zinc and iron levels in pre-eclampsia. J Matern Fetal Med 10:246–250

    CAS  PubMed  Google Scholar 

  34. Joshi VK, Sapre S, Govilla V (2003) Role of micronutrients and calcium in pregnancy induced hypertension. Obs Gynae Today 8:617–619

    Google Scholar 

  35. Sukonpan K, Phupong V (2005) Serum calcium and serum magnesium in normal and pre-eclamptic pregnancy. Arch Gynecol Obstet 273:12–16

    Article  CAS  PubMed  Google Scholar 

  36. Standley CA, Whitty JE, Mason BA, Cotton DB (1997) Serum ionized magnesium levels in normal and preeclamptic gestation. Obstet Gynecol 89:24–27

    Article  CAS  PubMed  Google Scholar 

  37. Golmohammed S, Amirabi lou A, Yazdian M, Pashapour N (2008) Evaluation of serum calcium, magnesium, copper, and zinc levels in women with pre-eclampsia. Iran J Med Sci 33:231–234

    Google Scholar 

  38. Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, Dersimonian R, Esterlitz JR, Raymond EG, Bild DE, Clemens JD, Cutler JA (1997) Trial of calcium to prevent preeclampsia. N Eng J Med 337:69–76

    Article  CAS  Google Scholar 

  39. Kisters K, Korner J, Lowen F, Witteler R, Jackisch C, Zidek W, Ott S, Westermann G, Barenbrock M, Rahn KH (1998) Plasma and membrane calcium ion and magnesium concentrations in normal pregnancy and pre-eclampsia. Gynaecol Obstet Invest 46:158–163

    Article  CAS  Google Scholar 

  40. Kosch M, Hausberg M, Louwen F, Barenbrock M, Rahn KH, Kisters K (2000) Alterations of plasma calcium and intracellular and membrane calcium in erythrocytes of patients with pre-eclampsia. J Hum Hypertens 14:333–336

    Article  CAS  PubMed  Google Scholar 

  41. Malas NO, Shurideh ZM (2001) Does serum calcium in pre-eclampsia and normal pregnancy differ? Saudi Med J 22:868–871

    CAS  PubMed  Google Scholar 

  42. Steinert JR, Wyatt AW, Poston L, Jacob R, Mann GE (2002) Preeclampsia is associated with altered Ca2+ regulation and NO production in human fetal venous endothelial cells. FASEB 16:721–738

    CAS  Google Scholar 

  43. Sanders GT, Huijgen HJ, Sanders R (1999) Magnesium in disease: a review with special emphasis on the serum ionized magnesium. Clin Chem Lab Med 37:1011–1033

    Article  CAS  PubMed  Google Scholar 

  44. Villanueva LA, Figueroa A, Villanueva S (2001) Blood concentrations of calcium and magnesium in women with severe pre-eclampsia. Ginecol Obstet Mex 69:277–281

    CAS  PubMed  Google Scholar 

  45. Prema K (1980) Predictive value of serum copper and zinc in normal and abnormal pregnancy. Indian J Med Res 71:554–560

    CAS  PubMed  Google Scholar 

  46. Borella P, Szilagyi A, Than G, Csaba I, Giardino A, Faccinetti F (1990) Maternal plasma concentrations of magnesium, calcium, zinc and copper in normal and pathological pregnancies. Sci Total Environ 99:67–76

    Article  CAS  PubMed  Google Scholar 

  47. Ajayi G (1993) Concentrations of calcium, magnesium, copper, zinc and iron during normal and EPH-gestosis pregnancy. Trace Element Med 10:151–152

    Google Scholar 

  48. Ette A, Ibeziako PA (1985) Plasma zinc and copper concentrations in pregnant Nigerian women and newborn. Afr J Med Sci 14:99–103

    CAS  Google Scholar 

  49. Ilhan N, Simsek M (2002) The changes of trace element, malondialdehyde levels and super oxide dismutase activities in pregnancy with or without pre-eclampsia. Clin Biochem 35:393–397

    Article  CAS  PubMed  Google Scholar 

  50. Power ML, Heaney RP, Kalkwarf HJ, Pitkin RM, Repke JT, Tsang RC, Schulkin J (1999) The role of calcium in health and disease. Am J Obstet Gynecol 181:1560–1569

    Article  CAS  PubMed  Google Scholar 

  51. Skjaerven R, Wilcox A, Lie RT (2002) The interval between pregnancies and the risk of pre-eclampsia. N Engl J Med 346:33–38

    Article  PubMed  Google Scholar 

  52. Altura BM, Altura BT (1984) Magnesium, electrolyte transport and coronary vascular tone. Drug 28(S):120–142

    Article  CAS  Google Scholar 

  53. Kumar CA, Das UN (2000) Lipid peroxides anti-oxidants and nitric oxide in patients with pre-eclampsia and essential hypertension. Med Sci Monit 6:901–907

    CAS  PubMed  Google Scholar 

  54. Roberts JM, Redman CWG (1993) Pre-eclampsia: more than pregnancy induced hypertension. Lancet 341:1447–1451

    Article  CAS  PubMed  Google Scholar 

  55. Thakur S, Gupta N, Kakkar P (2004) Serum copper and zinc concentrations and their relation to superoxide dismutase in severe malnutrition. Eur J Pediatr 163:742–744

    Article  CAS  PubMed  Google Scholar 

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  1. S.N. Medical College, Agra, India

    Seema Jain, Priyamvada Sharma, Shobha Kulshreshtha, Govind Mohan & Saroj Singh

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  1. Seema Jain
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  2. Priyamvada Sharma
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Correspondence to Priyamvada Sharma.

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Jain, S., Sharma, P., Kulshreshtha, S. et al. The Role of Calcium, Magnesium, and Zinc in Pre-Eclampsia. Biol Trace Elem Res 133, 162–170 (2010). https://doi.org/10.1007/s12011-009-8423-9

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