Abstract
Purpose
P27kip1 is a negative cell cycle regulator that plays an important role in tumor suppression. Deregulation of p27kip1 is commonly observed in many human cancers. Numerous studies about p27kip1 are reported in clinical patients despite variable data for the prognostic of p27kip1 expression. Here we report a meta-analysis of the association of p27kip1 expression with the survival of ovarian cancer.
Methods
PubMed and Web of science were searched for studies evaluating expression of p27kip1 and prognostic in ovarian cancer. Published data were extracted and computed into odds ratios (ORs) for death at 3 and 5 years. Data were pooled using the random-effect model. All statistical tests were two-sided.
Results
Analysis included 9 studies: six studies were reported in European, three studies were reported in American, and one study was reported in Asian. Loss of p27kip1 was associated with worse overall survival (OS) at both 3 years [OR = 2.61, 95 % confidence interval (CI) 1.95–3.49, p < 0.05] and 5 years (OR = 3.01, 95 % CI 2.17–4.17, p < 0.05). Among studies with different ethnicity (European, American and Asian), the results showed a more significant association in European, including Italy, Germany, and Greece [for both 3-year OS (OR = 3.53, 95 % CI 2.37–5.26) and 5-year OS (OR = 3.66, 95 % CI 2.30–5.83)].
Conclusions
Loss of p27kip1 is associated with worse survival in ovarian cancer. The development of strategies target p27kip1 could be a reasonable therapeutic approach.
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Acknowledgments
This work was supported by the National Natural Scientific Foundation of China Grant (No. 30872999;81372480), a grant RC2011033 from Revitalize and defend the key talent’s subsidy project in science and education of department of public health of Jiangsu Province; a grant 201318101-13 from Xinjiang Uygur Autonomous Region Natural Science Foundation of China, Wuxi hospital management center medical technology development fund (YGM1401), Wuxi science and technological developmental project (CSE31N1427). The authors have no conflict of interest to declare.
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Lu, M., Wang, Y., Xu, F. et al. The prognostic of p27kip1 in ovarian cancer: a meta-analysis. Arch Gynecol Obstet 293, 169–176 (2016). https://doi.org/10.1007/s00404-015-3817-8
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DOI: https://doi.org/10.1007/s00404-015-3817-8