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Comparison of tissue prolidase enzyme activity and serum oxidative stress level between pregnant women with placental abruption and those with a healthy pregnancy

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Purpose

Although placental abruption is an acute condition, it is thought that the underlying pathology is chronic vasculopathy. Collagen is one of the important components of vascular structure, and there is a correlation between collagen turnover and prolidase enzyme activity (PEA). Thus, our aim was to assess whether there is a difference in serum oxidative stress level and PEA between pregnant women with placental abruption and those with a healthy pregnancy.

Methods

The study group consisted of 36 pregnant women who underwent caesarean section with a diagnosis of placental abruption, while the control group comprised 36 pregnant women who underwent caesarean section due to obstetric reasons. Venous blood samples were drawn from all patients before caesarean section. In addition, tissue samples were obtained during caesarean section to evaluate tissue PEA.

Results

No significant differences in demographic characteristics were detected between groups (p > 0.05). Oxidative stress parameters, such as total oxidant status and oxidative stress index, were found to be significantly higher in the study group (p < 0.001). Placental tissue PEA was found to be significantly higher in pregnant women with placental abruption (557.21 ± 135.41 vs. 426.68 ± 131.57 U/g, p < 0.001). In addition, a significant positive correlation was detected between PEA and oxidative stress parameters (r = 0.332, p = 0.004).

Conclusions

Our results indicated that elevated tissue PEA and serum oxidative stress levels are closely related to placental abruption. Thus, we think that increased collagen turnover may have a significant role in the aetiopathogenesis of placental abruption.

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Conflict of interest

The authors have stated explicitly that there is no financial support or relationships that may pose potential conflict of interest in this article.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Faculty of Medicine, Harran University, Yenisehir Campus, 63300, Sanliurfa, Turkey

    Adnan Incebiyik, Aysun Camuzcuoglu, Hakan Camuzcuoglu & Nese Gul Hilali

  2. Department of Gynecology and Obstetrics, Faculty of Medicine, Marmara University, Istanbul, Turkey

    Mehmet Vural

  3. Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey

    Abdullah Taskin & Nurten Aksoy

  4. Department of Gynecology and Obstetrics, Sanliurfa Obstetrics and Gynecology Hospital, Sanliurfa, Turkey

    Halef Aydin

Authors
  1. Adnan Incebiyik
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  2. Mehmet Vural
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  3. Aysun Camuzcuoglu
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  4. Hakan Camuzcuoglu
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  5. Nese Gul Hilali
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  6. Abdullah Taskin
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  7. Halef Aydin
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  8. Nurten Aksoy
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Corresponding author

Correspondence to Adnan Incebiyik.

Additional information

The summary of this article was sent to XXIV European Congress of Perinatal Medicine; June 4–7th 2014 Florence/Italy.

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Incebiyik, A., Vural, M., Camuzcuoglu, A. et al. Comparison of tissue prolidase enzyme activity and serum oxidative stress level between pregnant women with placental abruption and those with a healthy pregnancy. Arch Gynecol Obstet 291, 805–809 (2015). https://doi.org/10.1007/s00404-014-3481-4

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  • DOI: https://doi.org/10.1007/s00404-014-3481-4

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