Skip to main content
SpringerLink
Log in

Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

To determine the levels of oxidative stress markers in recurrent pregnancy loss using a novel automated method.

Materials and methods

30 pregnant women in their first trimester with a history of recurrent pregnancy loss (RPL) and 30 healthy pregnant women were enrolled in this prospective controlled study. Total antioxidant capacity (TAC), total oxidant level (TOL) and oxidative stress index (OSI) in maternal serum were measured using the more recently designated Erel method.

Results

We observed statistically significant increased TOL and OSI levels in patient group (p = 0.032, p = 0.007, respectively). We also demonstrated statistically significant decreased TAC in pregnant women who had a history of RPL (p = 0.013).

Conclusion

Our results support the concept that oxidative stress plays a central role in the etiopathogenesis of RPL. Further studies to evaluate the predictive role of TAC, TOL, OSI levels using Erel method are needed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Wilcox AJ, Weinberg CR, O’Connor JF (1988) Incidence of early loss of pregnancy. N Engl J Med 319:189–194

    Article  CAS  PubMed  Google Scholar 

  2. Gupta S, Agarwal A, Banerjee J, Alvarez JG (2007) The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review. Obstet Gynecol Surv 62:335–347

    Article  PubMed  Google Scholar 

  3. Halliwell B, Gutteridge JMC (1984) Lipid peroxidation oxygen radicals, cell damage and antioxidant therapy. Lancet 23:1396–1397

    Article  Google Scholar 

  4. Hochstein P, Atallah AS (1988) The nature of oxidant and antioxidant systems in the inhibition of mutation and cancer. J Mut Res. 202:363–375

    Article  CAS  Google Scholar 

  5. Erel O (2004) A novel automated method to measure total antioxidant response against potent free radical reactions. J Clin Biochem 37:112–119

    Article  CAS  Google Scholar 

  6. Erel O (2005) A new automated colorimetric method for measuring total oxidant status. J Clin Biochem 47:119–129

    Google Scholar 

  7. Ozturk E, Balat O, Acılmıs YG, Ozcan C, Pence S, Erel O (2011) Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method. J Obstet Gynaecol Res. 37:337–342

    Article  CAS  PubMed  Google Scholar 

  8. Burton GJ, Jauniaux E (2004) Placental oxidative stress: from miscarriage to preeclapmsia. J Soc Gynecol Investig 11:342–352

    Article  CAS  PubMed  Google Scholar 

  9. Harma M, Harma M (2006) Defective placentation and resultant oxidative stress play a similar role in complete hydatidiform mole to that in preeclampsia and early pregnancy loss. Med Hypotheses 66:100–102

    Article  CAS  PubMed  Google Scholar 

  10. Poston L, Raijmakers MT (2004) Trophoblast oxidative stress, antioxidants and pregnancy outcome—a review. Placenta 25:72–78

    Article  Google Scholar 

  11. Safronova VG, Matveeva NK, Avkhacheva NV, Sidel’nikova VM, Van’ko LV, Sukhikh GT (2003) Changes in regulation of oxidase activity of peripheral blood granulocytes in women with habitual abortions. Bull Exp Biol Med 136:257–260

    Article  CAS  PubMed  Google Scholar 

  12. Vural P, Akgül C, Yildirim A, Canbaz M (2000) Antioxidant defence in recurrent abortion. Clin Chim Acta 295:169–177

    Article  CAS  PubMed  Google Scholar 

  13. Simşek M, Naziroğlu M, Simşek H, Cay M, Aksakal M, Kumru S (1998) Blood plasma levels of lipoperoxides, glutathione peroxidase, beta carotene, vitamin A and E in women with habitual abortion. Cell Biochem Funct 16:227–231

    Article  PubMed  Google Scholar 

  14. El-Far M, El-Sayed IH, El-Motwally Ael G, Hashem IA, Bakry N (2007) Tumor necrosis factor-alpha and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions. Clin Chem Lab Med 45:879–880

    Article  CAS  PubMed  Google Scholar 

  15. Schlesier K, Harwat M, Bohm V, Bitsch R (2002) Assessment of antioxidant activity by using different invitro methods. Free Radic Res 36:177–187

    Article  CAS  PubMed  Google Scholar 

  16. Janaszewska A, Bartosz G (2002) Assay of total antioxidant capacity: comparison off our methods as applied to human blood plasma. Scand J Clin Lab Invest 62:231–232

    Article  CAS  PubMed  Google Scholar 

  17. Erel O (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37(4):277–285

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of OB&GYN, Faculty of Medicine, Gaziantep University, Sahinbey, Turkey

    Özgür Bilgin Yiyenoğlu, Mete Gürol Uğur, Hüseyin Çağlayan Özcan, Günay Can, Ebru Öztürk & Özcan Balat

  2. Department of Clinical Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey

    Özcan Erel

  3. Tip Fakultesi, Kadin Hastaliklari ve Dogum Anabilim Dali, Sahinbey Uygulama ve Arastirma Hastanesi, Gaziantep Universitesi, Sahinbey, Gaziantep, Turkey

    Mete Gürol Uğur

Authors
  1. Özgür Bilgin Yiyenoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mete Gürol Uğur
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hüseyin Çağlayan Özcan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Günay Can
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ebru Öztürk
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Özcan Balat
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Özcan Erel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mete Gürol Uğur.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yiyenoğlu, Ö.B., Uğur, M.G., Özcan, H.Ç. et al. Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study. Arch Gynecol Obstet 289, 1337–1340 (2014). https://doi.org/10.1007/s00404-013-3113-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-013-3113-4

Keywords

Search

Navigation