Abstract
Objective
To compare the efficacies and side effects of Iodine-125 (125I) seeds implantation with afterloading radiotherapy on tumor xenografts derived from Hela cells.
Methods
Mice bearing Hela cells were randomly divided into three groups: two therapeutic groups receiving four 125I seeds implantation and afterloading therapy, respectively, and the one control group without any intervention. Comparisons were evaluated in aspects of curative efficacies (tumor volume, tumor inhibition rate and metastasis) and side effects (body weight, ovarian endocrine functions, skin lesion surrounding the tumor).
Results
The xenografts tumor volume of therapeutic groups were significantly smaller than that of controls(p < 0.05),both of the 125I seeds implantation and afterloading therapy showed excellent tumor inhibition rate. Furthermore, 125I seeds implantation had milder side effects on skin, weight loss, ovarian endocrine functions.
Conclusions
125I seed implantation may be an alternative minimally invasive therapy for cervical cancer.
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H. Li and J. Zhao contributed equally to this work.
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Li, Hx., Zhao, J., Shen, K. et al. Comparison of Iodine-125 seeds implantation and afterloading radiotherapy in murine models of human cervical cancer. Arch Gynecol Obstet 289, 1101–1106 (2014). https://doi.org/10.1007/s00404-013-3107-2
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DOI: https://doi.org/10.1007/s00404-013-3107-2