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Prevalence of human papillomavirus infection among women with and without normal cervical histology in Shandong Province, China

  • Gynecologic Oncology
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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The purpose of this study was to investigate the prevalence of human papillomavirus (HPV) genotypes infection in women with and with normal cervical histology in the littoral region of Shandong, China.

Methods

Scrape specimens were collected from 4,601 women for Pap smear and HPV genotypes identification. 1,489 women without normal cytology or with cervical disease were referred for colposcopic examination and biopsy procedures.

Results

The HPV infection in healthy women of the littoral region of Shandong (9.61%) is lower than that observed in previous studies in China and much less than in the high-risk areas. HPV infection prevalence was 14.23% in cervicitis with normal cervical histology, which was significantly lower than that of the women without normal cervical histology (60.12%, P = 0.00). Compared to prevalence of high-risk (HR) HPV genotypes (11.04%) in cervicitis with normal cervical histology, HR HPV genotypes prevalence (59.82%) was significantly higher in women without normal cervical histology (P = 0.003). HPV types 16, 52, 58, and 31 were the most prevalent HPV genotypes found in women without normal cervical histology. No statistical difference was observed for multiple HR HPV genotypes infection between women with and without normal cervical histology (P = 0.892).

Conclusion

Compared with prevalence rates for other populations, the prevalence of specific-HPV genotypes infecting women is different in the littoral region of Shandong Province, China.

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Acknowledgments

We thank all of the clinicians and gynecologists at our institution that performed diagnosis, treatment, and follow-up.

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Authors and Affiliations

  1. Department of Clinical Laboratory, Weihai Municipal Hospital, Dalian Medical University, Weihai, 264200, Shandong, China

    Xiaoyan Yuan, Yan Yang, Donghong Gu, Haiqing Yang & Mingyi Wang

  2. Department of Obstetrics and Gynecology, Weihai Municipal Hospital, Dalian Medical University, Weihai, Shandong, China

    Haining Liu

Authors
  1. Xiaoyan Yuan
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  2. Yan Yang
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  3. Donghong Gu
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  4. Haining Liu
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  5. Haiqing Yang
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  6. Mingyi Wang
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Corresponding author

Correspondence to Mingyi Wang.

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Yuan, X., Yang, Y., Gu, D. et al. Prevalence of human papillomavirus infection among women with and without normal cervical histology in Shandong Province, China. Arch Gynecol Obstet 283, 1385–1389 (2011). https://doi.org/10.1007/s00404-010-1584-0

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  • DOI: https://doi.org/10.1007/s00404-010-1584-0

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