Skip to main content

Advertisement

SpringerLink
Log in

Vaginal osseous metaplasia

  • Case Report
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Osseous metaplasia is an unusual event in the gynecologic organs. It has been reported mostly in the endometrium and rarely in the cervix.

Case

The authors describe a rare case of bone formation in vaginal mucosa of a 52-year-old woman with chronic pelvic pain and exteriorization of bone from vaginal introit.

Conclusion

To our knowledge, this finding has not been reported yet in the English medical literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Gal-Gombos EC, Esserman LE, Poniecka AW, Odzer SL, Weisberg S, Godinez J et al (2002) Osseuos metaplasia of the breast: diagnosis with stereotactic core biopsy. Breast J 8(1):50–52

    Article  PubMed  Google Scholar 

  2. Haines RW, Mohuiddin A (1968) Metaplastic bone. J Anat 103(3):527–538

    PubMed  CAS  Google Scholar 

  3. Daley TD, Damm DD, Wysocki GP, Weir JC (1997) Atypical cartilage in reactive osteocartilagenous metaplasia of the traumatized edentulous mandibular ridge. Oral and maxillofacial pathology 83:26–29

    CAS  Google Scholar 

  4. Meyer AJ, Kausch I, Behm A, Kruger S, Doehn C, Jocham D (2006) Der harnleiterknochen. Urologe 45:1438–1440

    Article  PubMed  CAS  Google Scholar 

  5. Al-Daraji WI, Abdellaoui A, Salman WD (2005) Osseous metaplasia in a tubular adenoma of the colon. J Clin Pathol 58:220–221. doi:10.1136/jcp. 2004.020685

    Article  PubMed  CAS  Google Scholar 

  6. Giele H, Hollowood K, Gibbons CLMH, Wilson DJ, Athanasou NA (2003) Subungueal melanoma with osteocartilagenous differentiation. Skeletal Radiol 32:724–727. doi:10.1007/s00256-003-0697-y

    Article  PubMed  CAS  Google Scholar 

  7. Dayoub S, Devlin H, Sloan P (2003) Evidence for the formation of metaplastic bone from pericytes in calcifying fibroblastic granuloma. J Oral Pathol Med 32:232–236

    PubMed  CAS  Google Scholar 

  8. Nijweide PJ, van Iperen G, Kawilarang EWM, van der Plas A, Wassenaar AM (1982) Bone formation and calcification by isolated osteoblastlike cells. J Cell Biol 93:318–323. doi:10.1083/jcb.93.2.318

    Article  PubMed  CAS  Google Scholar 

  9. Lew H, Shin DH, Lee SY, Kim SJ, Jang JW (2000) Osseous metaplasia with functioning bone marrow in hydroxyapatite orbital implants. Graefes Arch Clin Exp Ophthalmol 238:366–368

    Article  PubMed  CAS  Google Scholar 

  10. Jacono AA, Sclafani AP, van de Water T, Mccormick S, Frenz D (2001) Metaplastic bone formation in nasal polyps with histologic presence of transforming growth factor B1 (TGFB-1) and bone morphogenetic proteins (BMPs). Otolaryngol Head Neck Surg 125:96–97. doi:10.1067/mhn.2001.115857

    Article  PubMed  CAS  Google Scholar 

  11. Asanuma A, Sonoki H, Koga T (1995) Experimental myocardial infarction with cartilagenous and osseus metaplasia in SHR and WKY rats. Exp Anim 44(2):163–167

    Article  PubMed  CAS  Google Scholar 

  12. Akbulut M, Ege CB, Kelten EC, Soysal ME (2007) A probable secondary infertility due to osseous metaplasia of the endometrium. Arch Gynecol Obstet 277:563–565. doi:10.1007/s00404-007-0515-1

    Article  Google Scholar 

  13. Bahçeci M, Demirel LC (1996) Osseous metaplasia of the endometrium: a rare cause of infertility and its hysteroscopic management. Hum Reprod 11(11):2537–2539

    PubMed  Google Scholar 

  14. Cicinelli E, Stanziano A, Parisi C, Marinaccio M, Causio F (2005) Hysteroscopic diagnosis and treatment of endocervical ossification: a case report. J Minim Invasive Gynecol 12:159–161. doi:10.1016/j.jmig.2005.01.006

    Article  PubMed  Google Scholar 

  15. Bolaji II, Saridogan E, Hasan N, Baithun S, Djahanbakhch O (1995) Prolonged retention of fetal bones with osseous metaplasia of the endometrium. Int J Gynecol Obstretics 50:65–66

    Article  CAS  Google Scholar 

  16. Bhatia NN, Hoshiko MG (1982) Uterine osseous metaplasia. Obstet Gynecol 60(2):256–259

    PubMed  CAS  Google Scholar 

  17. Buselmeier TJ, Uecker JH (1979) Invasive basal cell carcinoma with metaplastic bone formation associated with a long-standing dermatofibroma. J Cutan Pathol 6(6):496–500. doi:10.1111/j.1600-0560.1979.tb01177.x

    Article  PubMed  CAS  Google Scholar 

  18. Zamonin ZA, Teti A, Iurato S (1983) Metaplastic bone tissue in tympanosclerosis. Acta Otolaryngol 95(5–6):554–559

    Google Scholar 

  19. Hayashi K, ohtsuki Y, Sonobe H, Hikita T, Iwata J, Furihata M, Mizobuchi T (1989) A case of malignant transformation of gastic hyperplastic polyp with metaplastic bone formation. Gan No Rinsho 35(7):851–854

    PubMed  CAS  Google Scholar 

  20. Ohtsuki Y, Danbara Y, Takeda I, Takahashi K, Hayashi K, Sonobe H et al (1987) Metaplastic bone formation in a hyperplastic polyp of the stomach: a case report. Acta Med Okayama 41(1):43–46

    PubMed  CAS  Google Scholar 

  21. Corcoran GM, Frazier SR, Prayson RA (2001) Choroid plexus papilloma with osseus and adipose metaplasia. Ann Diagn Pathol 5(1):43–47

    Article  PubMed  CAS  Google Scholar 

  22. Kim JY, Lee TJ, Chi JG (1996) Congenital quadrigeminal lipoma with osteocartilagenous element. J Korean Med Sci 11(6):537–539

    PubMed  CAS  Google Scholar 

  23. Zahariadis G, kontogeorgos G, liberopoulos K, George S, Kovacs K (1999) Ossifying pituitary gonadotroph adenoma: a case report. Acta Neurochir (Wien) 141:1001–1004. doi:10.1007/s007010050407

    Article  CAS  Google Scholar 

  24. Shuangshoti S (1995) Metaplasia of bone in lungs and bronchi: report of 2 cases. J Med Assoc Thai 78(2):103–107

    PubMed  CAS  Google Scholar 

  25. Dirschmid K, Schmid E (1976) Osseous metaplasia of renal medulla. Med Klin 71(11):459–461

    PubMed  CAS  Google Scholar 

  26. Hadjiisky P, Donev S, renais J, scebat L (1980) Cartilage and bone formation in arterial wall. Basic Res Cardiol 75(2):365–367. doi:10.1007/BF01907584

    Article  PubMed  CAS  Google Scholar 

  27. Kotzias SA, Linthicum FH Jr (1985) Labyrinthine ossification: differences between two types of ectopic bone. Am J Otol 6(6):490–494

    PubMed  CAS  Google Scholar 

  28. DeBrule M, Mott RC, Funk C, Nixon BP, Armstrong DG (2004) Osseus metaplasia in plantar fibromatosis: a case report. J Foot Ankle Surg 43(6):430–432

    Article  PubMed  Google Scholar 

  29. Ruiz-Genao D, Pascual-Lopez P, Fraga S, Aragues M, Garcia-Diez A (2005) Osseus metaplasia in the setting of nephrogenic fibosing dermopathy. J Cutan Pathol 32:172–175. doi:10.1111/j.0303-6987.2005.00277.x

    Article  PubMed  Google Scholar 

  30. Charokopos N, Antonitsis P, Rouska E, Kostopoulos I, Charaf A, Spanos PK (2006) Cartilaginous and osseus metaplasia with bone marrow formation in the aortic valve of a patient with giant cell aortitis. Ann Thorac Surg 81:1877–1879. doi:10.1016/j.athoracsur.2005.07.039

    Article  PubMed  Google Scholar 

  31. Ninomiya J, Oyama T, Horiguhi J, Koibuchi Y, Yoshida T, Lijima K et al (2005) Two case of breast cancer with cartilaginous and osseus metaplasia. Breast Cancer 12(1):52–56

    Article  PubMed  Google Scholar 

  32. Wajstaub S, Deb P, Chorneyko K (2002) Undifferentiated sarcoma of the parotid gland with osseous metaplasia. Arch Pathol Lab Med 126:849–852

    PubMed  Google Scholar 

  33. Lepore V, Geijer M, Petursdottir V, Jeppsson A (2000) Ectopic metaplastic ossification after sternotomy. Ann Thorac Surg 70:1716–1718

    Article  PubMed  CAS  Google Scholar 

  34. Fernandez-Conde M, Serrano S, Alcover J, Aaron JE (1996) Bone metaplasia of urothelial mucosa: an unusual biological phenomenon causing kidney stones. Bone 18(3):289–291. doi:10.1016/8756-3282(95)00488-2

    Article  PubMed  CAS  Google Scholar 

  35. Narita T, Ohnuma H, Yokoyama S (1995) Peutz-jeghers syndrome with osseus metaplasia of the intestinal polyps. Pathol Int 45(5):388–392

    Article  PubMed  CAS  Google Scholar 

  36. Daoud RA, Watkins MJ, Brown G, Carr N (1999) Mature bone metaplasia in abdominal wall scar. Postgrad Med J 75:226–227

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery and Oncologic Surgeon, Dr Waldemar de Alcântara General Hospital, Member of International Gynecologic Cancer Society, Fortaleza, Ceará, Brazil

    Fábio Machado Landim

  2. Department of Urology, Dr Waldemar de Alcântara General Hospital, Fortaleza, Ceará, Brazil

    José Marconi Tavares

  3. Department of Pathology, Dr Waldemar de Alcântara General Hospital l, Fortaleza, Ceará, Brazil

    Deborah Nunes de Melo Braga

  4. Ceara Cancer Institute, Fortaleza, Ceará, Brazil

    Jose Erialdo da Silva Jr

  5. State University of Ceará, Fortaleza, Ceará, Brazil

    Joao Bosco Breckenfeld Bastos Filho & Roney Gonçalves Fechine Feitosa

  6. Rua Deputado Moreira da Rocha 840 apt 1700 Meireles, Fortaleza, Ceará, 60160060, Brazil

    Fábio Machado Landim

Authors
  1. Fábio Machado Landim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. José Marconi Tavares
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Deborah Nunes de Melo Braga
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jose Erialdo da Silva Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Joao Bosco Breckenfeld Bastos Filho
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Roney Gonçalves Fechine Feitosa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fábio Machado Landim.

Additional information

This data had been approved at the regional ethics’ committee in 10 October 2007.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Landim, F.M., Tavares, J.M., de Melo Braga, D.N. et al. Vaginal osseous metaplasia. Arch Gynecol Obstet 279, 381–384 (2009). https://doi.org/10.1007/s00404-008-0706-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-008-0706-4

Keywords

Search

Navigation