Summary
The ultrastructural aspects of cartilaginous and osseous foci developed in aorta of rabbits immunized against rat aorta homogenates was studied. Besides normal and modified smooth muscle cells, various types of transformed mediacytes were observed in and around these foci: some of them resembled connective and young mesenchymatous cells, others had the appearances of cartilaginous and osseous cells. The possible role of the modified (multipotential) smooth muscle cells in aortic chondro- and osteogenesis is considered in some cases. Following histogenetic pathway is suggested: s.m.c.→modified s.m.c.→young mesenchyme-like cells (“inducible osteogenic precursor cells”)→“chondro-mediacytes”, “osteomediacyte”.
Résumé
L'ultrastructure des foyers cartilagineux et osseux de la média aortique de lapin immunisé avec l'homogenat d'aorte hétérologue fut étudiée. A côté des cellules musculaires lisses normales et/ou modifiées, des aspects variés de médiacytes transformés s'observent dans et autour des foyers de métaplasie, notamment des aspects rappelant le fibroblaste, la cellule jeune mésenchymateuse, les cellules chondro et ostéoblastiques. Le rôle éventuel du myocyte modifié (“multipotentiel”) dans la chondro/ostéogénése aortique est envisagé dans certains cas et la séquence histogénétique suivante suggérée: cellule musculaire lisse→c.m.l. modifiée (myofibroblaste)→médiacyte jeune mésenchymateux (“cellule-précurseur ostéogène”) →chondro-médiacyte et ostéo-médiacyte.
Zusammenfassung
Die vorliegende Studie betrifft die ultrastrukturellen Aspekte von Knorpel- und Knochenherden, die sich in der Aorta von Kaninchen entwickeln, welche gegen Homogenate von Rattenaorta immunisiert wurden.
Neben normalen und modifizierten Muskelzellen wurden im Bereich und im Umkreis dieser Herde verschiedene Typen metaplasierter Myozyten beobachtet. Einige von ihnen ähnelten Mesenchymzellen, Knorpelzellen oder Knochenzellen. Die mögliche Rolle modifizierter multipotenter Myozyten bei der Knorpel- und Knochenentstehung in der Aorta wird diskutiert.
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With 13 figures
Partially supported by Grant 75 70935 of DGRST-France
Supported by a scholarship from Claude Bernard Foundation (Paris)
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Hadjiisky, P., Donev, S., Renais, J. et al. Cartilage and bone formation in Arterial Wall 2. Ultrastructural Patterns. Basic Res Cardiol 75, 365–377 (1980). https://doi.org/10.1007/BF01907584
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DOI: https://doi.org/10.1007/BF01907584