Abstract
Cell adhesion molecule 1 (CADM1) is one of the immunoglobulin super family adhesion molecules, that is proposed to contribute in the pathogenesis of various types of cutaneous T-cell lymphoma, including mycosis fungoides (MF). In this work, we decided to examine the immunohistochemical expression of CADM1 in MF specimens compared to premycotic parapsoriasis, benign inflammatory dermatosis and normal control skin specimens. 125 participants were enrolled (50 MF, 25 parapsoriasis, 25 inflammatory dermatosis, and 25 healthy controls). Patients were selected from the Outpatient Clinic of Dermatology and Venereology Department, Tanta University Hospitals. From all, 4 mm punch skin biopsies were taken and examined for CADM1 immunohistochemical expression. The current study revealed statistically significant upregulation of CADM1 expression in MF specimens in comparison to parapsoriasis, inflammatory dermatosis, and normal control specimens. Additionally, there was statistically significant positive correlation between CADM1 expression and progression of TNMB staging of MF disease. Therefore, it is possible to recommend CADM1 as a beneficial diagnostic immunohistochemical marker for differentiation between early stages of MF and both the premycotic parapsoriasis and benign inflammatory dermatosis. Moreover, it may be of value in early detection of neoplastic transformation of parapsoriasis as well as in assessment of MF progression.
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All authors certify that they have participated sufficiently in this work to take public responsibility for the content. YME Neinaa and IH El-Maadawy designed and supervised this work and reviewed the manuscript, IA Atteia collected tissue specimens and wrote the draft, YME Neinaa and DA Mohamed assessed and analysed the immunohistochemical score of this work and prepared figures. YME Neinaa wrote the results and discussion sections of this paper.
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Neinaa, YH., El-Maadawy, I., Atteia, I. et al. Cell adhesion molecule 1 expression in mycosis fungoides versus parapsoriasis versus inflammatory dermatosis: an immunohistochemical comparative study. Arch Dermatol Res 315, 2403–2411 (2023). https://doi.org/10.1007/s00403-023-02600-x
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DOI: https://doi.org/10.1007/s00403-023-02600-x