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Archives of Dermatological Research

, Volume 307, Issue 1, pp 1–10 | Cite as

Optical coherence tomography in the diagnosis of basal cell carcinoma

  • Alia Arif HussainEmail author
  • Lotte Themstrup
  • Gregor Borut Ernst Jemec
Review

Abstract

Since its introduction in dermatology in the late 1990s optical coherence tomography (OCT) has been used to study many skin diseases, in particular non-melanoma skin cancer and it s precursors. Special attention has been paid to superficial basal cell carcinoma (BCC), and a number of smaller observational studies have been published. The diagnostic criteria for BCC of these studies are systematically reviewed. A systemic review of English language studies was performed using PubMed, Google Scholar and Royal Danish Library, to search for primary papers on OCT and BCC. The references of retrieved papers were searched by hand for further relevant papers. A total of 39 papers were identified (search date: 2014-01-15). 22 were excluded because they did not meet the inclusion criteria, leaving 17 papers for analysis. In 100 % of the studies, rounded dark structures in the upper dermis surrounded by a hyperreflective halo possibly surrounded by a hyporeflective border and disruption of epidermal layering were described. In 53 % of the reports a hyporeflective lateral tumour border was described. A range of other features were mentioned in a minority of the studies. It is suggested that these diagnostic criteria could be characteristic for identifying BCC lesions using OCT.

Keywords

Optical coherence tomography High-definition optical coherence tomography Basal cell carcinoma Non-melanoma skin cancer Skin imaging Skin cancer 

Notes

Acknowledgments

The HD-OCT images were generously supplied by Dr. M.A.L.M Boone, Belgium. Conventional OCT images were kindly supplied by the ADVANCE project. The project has received funding from the European Union’s ICT Policy Support Programme as part of the Competitiveness and Innovation Framework Programme. This presentation reflects only the author’s views and the European Union is not liable for any use that might be made of information contained therein.

References

  1. 1.
    Alawi SA, Kuck M, Wahrlich C, Batz S, McKenzie G, Fluhr JW, Lademann J, Ulrich M (2013) Optical coherence tomography for presurgical margin assessment of non-melanoma skin cancer: a practical approach. Exp Dermatol 22(8):547–551. doi: 10.1111/exd.12196 PubMedCrossRefGoogle Scholar
  2. 2.
    Banzhaf CA, Themstrup L, Ring HC, Mogensen M, Jemec GBE (2014) Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy. Skin Res Technol 20(2):170–176. doi: 10.1111/srt.12102 PubMedCrossRefGoogle Scholar
  3. 3.
    Bechara FG, Gambichler T, Stucker M, Orlikov A, Rotterdam S, Altmeyer P, Hoffmann K (2004) Histomorphologic correlation with routine histology and optical coherence tomography. Skin Res Technol 10(3):169–173. doi: 10.1111/j.1600-0846.2004.00038.x PubMedCrossRefGoogle Scholar
  4. 4.
    Boone M, Jemec GB, Del Marmol V (2012) High-definition optical coherence tomography enables visualization of individual cells in healthy skin: comparison to reflectance confocal microscopy. Exp Dermatol 21(10):740–744. doi: 10.1111/j.1600-0625.2012.01569.x PubMedGoogle Scholar
  5. 5.
    Boone M, Norrenberg S, Jemec G, Del Marmol V (2013) High-definition optical coherence tomography: adapted algorithmic method for pattern analysis of inflammatory skin diseases: a pilot study. Arch Dermatol Res 305(4):283–297. doi: 10.1007/s00403-012-1311-8 PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Boone MA, Norrenberg S, Jemec GB, Del Marmol V (2012) Imaging of basal cell carcinoma by high-definition optical coherence tomography: histomorphological correlation. A pilot study. Br J Dermatol 167(4):856–864. doi: 10.1111/j.1365-2133.2012.11194.x PubMedCrossRefGoogle Scholar
  7. 7.
    Boone MA, Norrenberg S, Jemec GB, Del Marmol V (2013) Imaging actinic keratosis by high-definition optical coherence tomography. Histomorphologic correlation: a pilot study. Exp Dermatol 22(2):93–97. doi: 10.1111/exd.12074 PubMedCrossRefGoogle Scholar
  8. 8.
    Chan CS, Rohrer TE (2012) Optical coherence tomography and its role in Mohs micrographic surgery: a case report. Case Rep Dermatol 4(3):269–274. doi: 10.1159/000346237 PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Coleman AJ, Richardson TJ, Orchard G, Uddin A, Choi MJ, Lacy KE (2013) Histological correlates of optical coherence tomography in non-melanoma skin cancer. Skin Res Technol 19(1):10–19. doi: 10.1111/j.1600-0846.2012.00626.x PubMedCrossRefGoogle Scholar
  10. 10.
    Cunha D, Richardson T, Sheth N, Orchard G, Coleman A, Mallipeddi R (2011) Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery. Br J Dermatol 165(3):576–580. doi: 10.1111/j.1365-2133.2011.10461.x PubMedCrossRefGoogle Scholar
  11. 11.
    Dalimier E, Salomon D (2012) Full-field optical coherence tomography: a new technology for 3D high-resolution skin imaging. Dermatology 224(1):84–92PubMedCrossRefGoogle Scholar
  12. 12.
    Durkin JR, Fine JL, Sam H, Pugliano-Mauro M, Ho J (2014) Imaging of Mohs micrographic surgery sections using full-field optical coherence tomography: a pilot study. Dermatol Surg 40(3):266–274. doi: 10.1111/dsu.12419 PubMedCrossRefGoogle Scholar
  13. 13.
    Forsea AM, Carstea EM, Ghervase L, Giurcaneanu C, Pavelescu G (2010) Clinical application of optical coherence tomography for the imaging of non-melanocytic cutaneous tumors: a pilot multi-modal study. J Med Life 3(4):381–389PubMedCentralPubMedGoogle Scholar
  14. 14.
    Gambichler T, Jaedicke V, Terras S (2011) Optical coherence tomography in dermatology: technical and clinical aspects. Arch Dermatol Res 303(7):457–473. doi: 10.1007/s00403-011-1152-x PubMedCrossRefGoogle Scholar
  15. 15.
    Gambichler T, Moussa G, Sand M, Sand D, Altmeyer P, Hoffmann K (2005) Applications of optical coherence tomography in dermatology. J Dermatol Sci 40(2):85–94. doi: 10.1016/j.jdermsci.2005.07.006 PubMedCrossRefGoogle Scholar
  16. 16.
    Gambichler T, Orlikov A, Vasa R, Moussa G, Hoffmann K, Stucker M, Altmeyer P, Bechara FG (2007) In vivo optical coherence tomography of basal cell carcinoma. J Dermatol Sci 45(3):167–173. doi: 10.1016/j.jdermsci.2006.11.012 PubMedCrossRefGoogle Scholar
  17. 17.
    Gambichler T, Plura I, Kampilafkos P, Valavanis K, Sand M, Bechara FG, Stucker M (2014) Histopathological correlates of basal cell carcinoma in the slice and en face imaging modes of high-definition optical coherence tomography. Br J Dermatol 170(6):1358–1361. doi: 10.1111/bjd.12797 PubMedCrossRefGoogle Scholar
  18. 18.
    Hinz T, Ehler LK, Hornung T, Voth H, Fortmeier I, Maier T, Holler T, Schmid-Wendtner MH (2012) Preoperative characterization of basal cell carcinoma comparing tumour thickness measurement by optical coherence tomography, 20-MHz ultrasound and histopathology. Acta Derm Venereol 92(2):132–137. doi: 10.2340/00015555-1231 PubMedCrossRefGoogle Scholar
  19. 19.
    Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA et al (1991) Optical coherence tomography. Science 254(5035):1178–1181PubMedCrossRefGoogle Scholar
  20. 20.
    Jorgensen TM, Tycho A, Mogensen M, Bjerring P, Jemec GB (2008) Machine-learning classification of non-melanoma skin cancers from image features obtained by optical coherence tomography. Skin Res Technol 14(3):364–369. doi: 10.1111/j.1600-0846.2008.00304.x PubMedCrossRefGoogle Scholar
  21. 21.
    Kamyab-Hesari K, Seirafi H, Naraghi ZS, Shahshahani MM, Rahbar Z, Damavandi MR, Naraghi MM, Rezvani M, Aghazadeh N (2014) Diagnostic accuracy of punch biopsy in subtyping basal cell carcinoma. J Eur Acad Dermatol Venereol 28(2):250–253. doi: 10.1111/j.1468-3083.2012.04695.x CrossRefGoogle Scholar
  22. 22.
    Khandwala M, Penmetsa BR, Dey S, Schofield JB, Jones CA, Podoleanu A (2010) Imaging of periocular basal cell carcinoma using en face optical coherence tomography: a pilot study. Br J Ophthalmol 94(10):1332–1336. doi: 10.1136/bjo.2009.170811 PubMedCrossRefGoogle Scholar
  23. 23.
    Maier T, Braun-Falco M, Hinz T, Schmid-Wendtner MH, Ruzicka T, Berking C (2013) Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology. J Eur Acad Dermatol Venereol 27(1):e97–e104. doi: 10.1111/j.1468-3083.2012.04551.x PubMedCrossRefGoogle Scholar
  24. 24.
    Maier T, Braun-Falco M, Laubender RP, Ruzicka T, Berking C (2013) Actinic keratosis in the en-face and slice imaging mode of high-definition optical coherence tomography and comparison with histology. Br J Dermatol 168(1):120–128. doi: 10.1111/j.1365-2133.2012.11202.x PubMedCrossRefGoogle Scholar
  25. 25.
    Marschall S, Sander B, Mogensen M, Jorgensen TM, Andersen PE (2011) Optical coherence tomography-current technology and applications in clinical and biomedical research. Anal Bioanal Chem 400(9):2699–2720. doi: 10.1007/s00216-011-5008-1 PubMedCrossRefGoogle Scholar
  26. 26.
    Mogensen M, Jemec GB (2007) Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: a review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologies. Dermatol Surg 33(10):1158–1174. doi: 10.1111/j.1524-4725.2007.33251.x PubMedGoogle Scholar
  27. 27.
    Mogensen M, Joergensen TM, Nurnberg BM, Morsy HA, Thomsen JB, Thrane L, Jemec GB (2009) Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg 35(6):965–972. doi: 10.1111/j.1524-4725.2009.01164.x PubMedCrossRefGoogle Scholar
  28. 28.
    Mogensen M, Jorgensen TM, Thrane L, Nurnberg BM, Jemec GB (2010) Improved quality of optical coherence tomography imaging of basal cell carcinomas using speckle reduction. Exp Dermatol 19(8):e293–e295. doi: 10.1111/j.1600-0625.2009.00979.x PubMedCrossRefGoogle Scholar
  29. 29.
    Mogensen M, Nurnberg BM, Forman JL, Thomsen JB, Thrane L, Jemec GB (2009) In vivo thickness measurement of basal cell carcinoma and actinic keratosis with optical coherence tomography and 20-MHz ultrasound. Br J Dermatol 160(5):1026–1033. doi: 10.1111/j.1365-2133.2008.09003.x PubMedCrossRefGoogle Scholar
  30. 30.
    Mogensen M, Nurnberg BM, Thrane L, Jorgensen TM, Andersen PE, Jemec GB (2011) How histological features of basal cell carcinomas influence image quality in optical coherence tomography. J Biophotonics 4(7–8):544–551. doi: 10.1002/jbio.201100006 PubMedCrossRefGoogle Scholar
  31. 31.
    Mogensen M, Thrane L, Jorgensen TM, Andersen PE, Jemec GB (2009) OCT imaging of skin cancer and other dermatological diseases. J Biophotonics 2(6–7):442–451. doi: 10.1002/jbio.200910020 PubMedCrossRefGoogle Scholar
  32. 32.
    Olmedo JM, Warschaw KE, Schmitt JM, Swanson DL (2006) Optical coherence tomography for the characterization of basal cell carcinoma in vivo: a pilot study. J Am Acad Dermatol 55(3):408–412. doi: 10.1016/j.jaad.2006.03.013 PubMedCrossRefGoogle Scholar
  33. 33.
    Olmedo JM, Warschaw KE, Schmitt JM, Swanson DL (2007) Correlation of thickness of basal cell carcinoma by optical coherence tomography in vivo and routine histologic findings: a pilot study. Dermatol Surg 33(4):421–425. doi: 10.1111/j.1524-4725.2007.33088.x (discussion 425–426)PubMedGoogle Scholar
  34. 34.
    Pomerantz R, Zell D, McKenzie G, Siegel DM (2011) Optical coherence tomography used as a modality to delineate basal cell carcinoma prior to Mohs micrographic surgery. Case Rep Dermatol 3(3):212–218. doi: 10.1159/000333000 PubMedCentralPubMedCrossRefGoogle Scholar
  35. 35.
    Roozeboom MH, Mosterd K, Winnepenninckx VJ, Nelemans PJ, Kelleners-Smeets NW (2013) Agreement between histological subtype on punch biopsy and surgical excision in primary basal cell carcinoma. J Eur Acad Dermatol Venereol 27(7):894–898. doi: 10.1111/j.1468-3083.2012.04608.x PubMedCrossRefGoogle Scholar
  36. 36.
    Steiner R, Kunzi-Rapp K, Scharffetter-Kochanek K (2003) Optical coherence tomography: clinical applications in dermatology. Med Laser Appl 18(3):249–259. doi: 10.1078/1615-1615-00107 CrossRefGoogle Scholar
  37. 37.
    Swanson EA, Izatt JA, Hee MR, Huang D, Lin CP, Schuman JS, Puliafito CA, Fujimoto JG (1993) In vivo retinal imaging by optical coherence tomography. Opt Lett 18(21):1864–1866PubMedCrossRefGoogle Scholar
  38. 38.
    Themstrup L, Banzhaf CA, Mogensen M, Jemec GB (2014) Optical coherence tomography imaging of non-melanoma skin cancer undergoing photodynamic therapy reveals subclinical residual lesions. Photodiagnosis Photodyn Ther 11(1):7–12. doi: 10.1016/j.pdpdt.2013.11.003 PubMedCrossRefGoogle Scholar
  39. 39.
    Tycho AAP, Thrane L, Jemec GBE (2006) Optical coherence tomography in dermatology. In: Serup J, Jemec GBE, Grove GL (eds) Handbook of Non-invasive methods and the Ski, 2nd edn. Taylor and Francis Group, Florida, pp 257–266Google Scholar
  40. 40.
    Ulrich M, Roewert-Huber J, Gonzalez S, Rius-Diaz F, Stockfleth E, Kanitakis J (2011) Peritumoral clefting in basal cell carcinoma: correlation of in vivo reflectance confocal microscopy and routine histology. J Cutan Pathol 38(2):190–195. doi: 10.1111/j.1600-0560.2010.01632.x PubMedCrossRefGoogle Scholar
  41. 41.
    Wang KX, Meekings A, Fluhr JW, McKenzie G, Lee DA, Fisher J, Markowitz O, Siegel DM (2013) Optical coherence tomography-based optimization of Mohs micrographic surgery of Basal cell carcinoma: a pilot study. Dermatol Surg 39(4):627–633. doi: 10.1111/dsu.12093 PubMedCrossRefGoogle Scholar
  42. 42.
    Welzel J (2001) Optical coherence tomography in dermatology: a review. Skin Res Technol 7(1):1–9PubMedCrossRefGoogle Scholar
  43. 43.
    Wolberink EA, Pasch MC, Zeiler M, van Erp PE, Gerritsen MJ (2013) High discordance between punch biopsy and excision in establishing basal cell carcinoma subtype: analysis of 500 cases. J Eur Acad Dermatol Venereol 27(8):985–989. doi: 10.1111/j.1468-3083.2012.04628.x PubMedCrossRefGoogle Scholar
  44. 44.
    Ziolkowska M, Philipp CM, Liebscher J, Berlien H-P (2009) OCT of healthy skin, actinic skin and NMSC lesions. Med Laser Appl 24(4):256–264. doi: 10.1016/j.mla.2009.07.003 CrossRefGoogle Scholar
  45. 45.
    Zulfakar MH, Alex A, Povazay B, Drexler W, Thomas CP, Porter RM, Heard CM (2011) In vivo response of GsdmA3Dfl/+ mice to topically applied anti-psoriatic agents: effects on epidermal thickness, as determined by optical coherence tomography and H&E staining. Exp Dermatol 20(3):269–272. doi: 10.1111/j.1600-0625.2010.01233.x PubMedCrossRefGoogle Scholar

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Alia Arif Hussain
    • 1
    Email author
  • Lotte Themstrup
    • 1
  • Gregor Borut Ernst Jemec
    • 1
  1. 1.Department of Dermatology, Roskilde HospitalUniversity of CopenhagenRoskildeDenmark

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