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Nanoparticles in dermatology

  • Review Article
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Abstract

Recent advances in the field of nanotechnology have allowed the manufacturing of elaborated nanometer-sized particles for various biomedical applications. A broad spectrum of particles, extending from various lipid nanostructures such as liposomes and solid lipid nanoparticles, to metal, nanocrystalline and polymer particles have already been tested as drug delivery systems in different animal models with remarkable results, promising an extensive commercialization in the coming years. Controlled drug release to skin and skin appendages, targeting of hair follicle-specific cell populations, transcutaneous vaccination and transdermal gene therapy are only a few of these new applications. Carrier systems of the new generation take advantage of improved skin penetration properties, depot effect with sustained drug release and of surface functionalization (e.g., the binding to specific ligands) allowing specific cellular and subcellular targeting. Drug delivery to skin by means of microparticles and nanocarriers could revolutionize the treatment of several skin disorders. However, the toxicological and environmental safety of micro- and nanoparticles has to be evaluated using specific toxicological studies prior to a wider implementation of the new technology. This review aims to give an overview of the most investigated applications of transcutaneously applied particle-based formulations in the fields of cosmetics and dermatology.

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Abbreviations

APC:

Antigen-presenting cells

BSI:

British Standards Institution

CSSS:

Cyanoacrylate skin surface stripping

DDS:

Drug delivery system

EGFR:

Epidermal growth factor receptor

HBV:

Hepatitis B virus

HIV:

Human immunodeficiency virus

HPV:

Human papillomavirus

ISCOM:

Immune stimulating complexes

LC:

Langerhans cells

MHC:

Major histocompatibility complex

MRI:

Magnetic resonance imaging

P(CL):

Poly(ε-caprolactone)

PDT:

Photodynamic therapy

PLA:

Poly-lactic acid

PLGA:

Poly(lactic-co-glycolic) acid

PS:

Polystyrene

PTT:

Photothermal therapy

QD:

Quantum dots

RSV:

Respiratory syncytial virus

SLN:

Solid lipid nanoparticles

SPF:

Sunscreen protection factor

UV:

Ultraviolet

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Authors and Affiliations

  1. Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    Dimitrios Papakostas, Fiorenza Rancan, Wolfram Sterry, Ulrike Blume-Peytavi & Annika Vogt

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  1. Dimitrios Papakostas
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  2. Fiorenza Rancan
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  3. Wolfram Sterry
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  4. Ulrike Blume-Peytavi
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  5. Annika Vogt
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Correspondence to Annika Vogt.

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D. Papakostas and F. Rancan contributed equally to this work.

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Papakostas, D., Rancan, F., Sterry, W. et al. Nanoparticles in dermatology. Arch Dermatol Res 303, 533–550 (2011). https://doi.org/10.1007/s00403-011-1163-7

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