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Lack of association between NPHS2 gene polymorphisms and Henoch-Schönlein purpura nephritis

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Abstract

Henoch-Schönlein purpura (HSP) is one of the most common forms of small-vessel vasculitis in childhood, and renal involvement (HSP nephritis, HSPN) is the main determinant of morbidity after acute phase. Considering the racial diversity and clinical heterogeneity in the prevalence, genetic factors might play a role in pathogenesis of HSP and HSPN. Direct sequencing was performed after PCR amplification of all 8 exons of the NPHS2 gene in 20 Chinese children with HSPN and 30 controls in present study. The genetic analyses revealed 3 polymorphisms (954T > C heterozygous, 1038A > G heterozygous and homozygous, all in exon 8) in 7 out of 20 patients studied, but there was no significant difference in the genotypic and allelic frequencies of these polymorphisms between the patients and controls. The result did not support the possible role of the NPHS2 gene in susceptibility to HSPN in the population studied. Studies in a larger sample population with different genetic backgrounds will be necessary in the future.

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Acknowledgments

The authors thank Wu Yedong, Sheng Zheng and Yu Zhongsheng for their excellent technical assistance, and Dr Huang Yaping for many helpful clinical advices. The authors are also grateful for Dr Wu Dehua and Zhang Chong for providing control materials to us. The project is supported by: (1) Zhejiang Provincial Natural Science Foundation of China, No. Y206058 and No. Y204148. (2) Zhejiang provincial Healthy Science Foundation, No. 2004QN014. (3) Zhejiang provincial Educational Foundation, No. 20040233.

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Authors and Affiliations

  1. Department of Epidemiology, Zhejiang University School of Medicine, Hangzhou, 310031, Zhejiang Province, People’s Republic of China

    Yang Zhang

  2. Department of Surgery, 117th Hospital of People’s Liberation Army, No. 40 Airport Road, Hangzhou, 310004, Zhejiang Province, People’s Republic of China

    Xu Xudong

  3. Department of Nephrology, The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, People’s Republic of China

    Lizhong Du, Yuwen Dai, Aimin Liu, Yonghui Xia & Jianhua Mao

  4. Department of Pathology, The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, People’s Republic of China

    Weizhong Gu

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  1. Yang Zhang
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Correspondence to Jianhua Mao.

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Zhang, Y., Xudong, X., Du, L. et al. Lack of association between NPHS2 gene polymorphisms and Henoch-Schönlein purpura nephritis. Arch Dermatol Res 299, 151–155 (2007). https://doi.org/10.1007/s00403-007-0752-y

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  • DOI: https://doi.org/10.1007/s00403-007-0752-y

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