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Comparison of both lower leg bone mineral density in single limb knee osteoarthritis patients

  • Knee Arthroplasty
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Purpose

The relationship between knee osteoarthritis (OA), bone mineral density (BMD), and alignment has not yet been clarified. This study aimed to investigate the relationship between the two limbs in patients with single-limb knee OA.

Methods

Patients who underwent single-limb total knee arthroplasty between March 2019 and February 2021 were retrospectively analyzed. Only patients with Kellgren-Lawrence (KL) grades III and IV on the operated side and KL I and II on the opposite side were included. Patients with traumatic OA, a surgery that could change the alignment of both lower extremities and previous fractures were excluded. The proximal femur BMD on the OA and non-OA sides were compared. In addition, the difference in BMD was compared between a group with a difference in alignment of both lower extremities (> 5°) and a group without a difference (< 5°).

Results

In total, 149 patients were included. The BMD T-score of the femoral neck on the OA side was lower than that of the non-OA side (p < 0.001). There was no correlation between BMD and alignment, and there was no difference in BMD according to the difference in alignment.

Conclusion

The femoral neck BMD of the leg on the side with knee OA was lower than that on the side without OA. However, the alignment difference between the legs did not affect BMD. BMD was lowered because of OA and not because of alignment.

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Data availability

The data use to support the findings of the study are available from the corresponding author upon request.

References

  1. Akamatsu Y, Mitsugi N, Taki N, Takeuchi R, Saito T (2009) Relationship between low bone mineral density and varus deformity in postmenopausal women with knee osteoarthritis. J Rheumatol 36(3):592–597

    Article  PubMed  Google Scholar 

  2. Blagojevic M, Jinks C, Jeffery A, Jordan KP (2010) Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage 18(1):24–33

    Article  CAS  PubMed  Google Scholar 

  3. Higano Y, Hayami T, Omori G, Koga Y, Endo K, Endo N (2016) The varus alignment and morphologic alterations of proximal tibia affect the onset of medial knee osteoarthritis in rural Japanese women: Case control study from the longitudinal evaluation of Matsudai Knee Osteoarthritis Survey. J Orthop Sci 21(2):166–171

    Article  PubMed  Google Scholar 

  4. Im GI, Kwon OJ, Kim CH (2014) The relationship between osteoarthritis of the knee and bone mineral density of proximal femur: a cross-sectional study from a Korean population in women. Clin Orthop Surg 6(4):420–425

    Article  PubMed  PubMed Central  Google Scholar 

  5. Khamaisy S, Nam D, Thein R, Rivkin G, Liebergall M, Pearle A (2015) Limb alignment, subluxation, and bone density relationship in the osteoarthritic varus knee. J Knee Surg 28(3):207–212

    PubMed  Google Scholar 

  6. Kim YH, Lee JS, Park JH (2018) Association between bone mineral density and knee osteoarthritis in Koreans: the Fourth and Fifth Korea National Health and Nutrition Examination Surveys. Osteoarthritis Cartilage 26(11):1511–1517

    Article  CAS  PubMed  Google Scholar 

  7. Linde KN, Puhakka KB, Langdahl BL et al (2017) Bone mineral density is lower in patients with severe knee osteoarthritis and attrition. Calcif Tissue Int 101(6):593–601

    Article  CAS  PubMed  Google Scholar 

  8. Moon YW, Park JH, Lee SS, Kang JW, Lee DH (2020) Distal femoral phenotypes in Asian varus osteoarthritic knees. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-020-06131-0

    Article  Google Scholar 

  9. Palmer JS, Jones LD, Monk AP et al (2020) Varus alignment of the proximal tibia is associated with structural progression in early to moderate varus osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc 28(10):3279–3286

    Article  PubMed  PubMed Central  Google Scholar 

  10. Sharma L, Song J, Dunlop D et al (2010) Varus and valgus alignment and incident and progressive knee osteoarthritis. Ann Rheum Dis 69(11):1940–1945

    Article  PubMed  Google Scholar 

  11. Shen Y, Zhang YH, Shen L (2013) Postmenopausal women with osteoporosis and osteoarthritis show different microstructural characteristics of trabecular bone in proximal tibia using high-resolution magnetic resonance imaging at 3 tesla. BMC Musculoskelet Disord 14:136

    Article  PubMed  PubMed Central  Google Scholar 

  12. Stamenkovic BN, Rancic NK, Bojanovic MR et al (2022) Is osteoarthritis always associated with low bone mineral density in elderly patients? Medicina (Kaunas) 58(9):1207

    Article  Google Scholar 

  13. Tanamas S, Hanna FS, Cicuttini FM, Wluka AE, Berry P, Urquhart DM (2009) Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review. Arthritis Rheum 61(4):459–467

    Article  PubMed  Google Scholar 

  14. Wang SP, Wu PK, Lee CH, Shih CM, Chiu YC, Hsu CE (2021) Association of osteoporosis and varus inclination of the tibial plateau in postmenopausal women with advanced osteoarthritis of the knee. BMC Musculoskelet Disord 22(1):223

    Article  PubMed  PubMed Central  Google Scholar 

  15. Wen L, Shin MH, Kang JH et al (2016) The relationships between bone mineral density and radiographic features of hand or knee osteoarthritis in older adults: data from the Dong-gu Study. Rheumatology (Oxford) 55(3):495–503

    PubMed  Google Scholar 

  16. Zhang C, Zhuang Z, Chen X et al (2021) Osteoporosis is associated with varus deformity in postmenopausal women with knee osteoarthritis: a cross-sectional study. BMC Musculoskelet Disord 22(1):694

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Veterans Health Service Medical Center, 53 Jinhwangdo-ro 61-gil, Gangdong-gu, Seoul, 05368, South Korea

    Yun Seong Choi, Jin-Uk Jeong & Seung Hoon Lee

Authors
  1. Yun Seong Choi
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  2. Jin-Uk Jeong
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  3. Seung Hoon Lee
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Corresponding author

Correspondence to Seung Hoon Lee.

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Conflict of interest

The authors declare that we have no conflict of interest.

Ethical approval

All methods were performed in accordance with the relevant guidelines and regulations. This article was performed under the IRB permission (Veterans Health Service Medical Center International Review Board No: BOHUN BOHUN 2022-12-054).

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Informed consent was waived due to the retrospective nature of this study.

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Choi, Y.S., Jeong, JU. & Lee, S.H. Comparison of both lower leg bone mineral density in single limb knee osteoarthritis patients. Arch Orthop Trauma Surg 143, 7147–7151 (2023). https://doi.org/10.1007/s00402-023-04928-5

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  • DOI: https://doi.org/10.1007/s00402-023-04928-5

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