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Preoperative use of epoietin beta in total hip replacement: a prospective study

  • Orthopaedic Surgery
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Objective

Epoietin (EPO) effectively decreases perioperative blood transfusion requirements. We evaluated the feasibility of using EPO beta to increase haemoglobin levels before total hip replacement (THR) and reduce transfusion.

Materials and methods

One hundred and seventy-one patients undergoing primary THR were included in this prospective observational study. Patients with initial haemoglobin level <130 g l−1 received EPO beta subcutaneously in a four-dose regimen. Haemoglobin levels were measured at baseline, before surgery, and at postoperative days 1 and 5.

Results

Twenty-eight patients received EPO beta preoperatively, 143 were not treated including 42 with initial haemoglobin level <130 g l−1. Haemoglobin increased by 29 ± 9 g l−1 in the low Hb + EPO group versus 2 ± 1 g l−1 for the other patients. In the low Hb + EPO group 3.6% were transfused, in the low HB group 45.2% (P = 0.001) and in the normal Hb group 11.9% (P = 0.2).

Conclusions

Preoperative EPO beta increases haemoglobin level and reduces transfusion frequency in anaemic patients before total joint replacement. It could play a major role in the management of perioperative blood loss in orthopaedic surgery.

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Authors and Affiliations

  1. Service de Chirurgie Orthopédique et Traumatologique, CHU de Rangueil, TSA 50032, 1, avenue Jean Poulhès, 31059, Toulouse Cedex 9, France

    Jean-Michel Laffosse & Philippe Chiron

  2. Département d’Anesthésie, CHU de Rangueil, TSA 50032, 1, avenue Jean Poulhès, 31059, Toulouse Cedex 9, France

    Vincent Minville, Aline Colombani, Claude Gris, Jean-Claude Pourrut, Bernard Eychenne & Olivier Fourcade

Authors
  1. Jean-Michel Laffosse
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  2. Vincent Minville
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  3. Philippe Chiron
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  4. Aline Colombani
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  5. Claude Gris
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  6. Jean-Claude Pourrut
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  7. Bernard Eychenne
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  8. Olivier Fourcade
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Correspondence to Jean-Michel Laffosse.

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Laffosse, JM., Minville, V., Chiron, P. et al. Preoperative use of epoietin beta in total hip replacement: a prospective study. Arch Orthop Trauma Surg 130, 41–45 (2010). https://doi.org/10.1007/s00402-009-0863-3

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  • DOI: https://doi.org/10.1007/s00402-009-0863-3

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