Abstract
Introduction
The purpose of this study was to elucidate the clinical significance of acid phosphatase in giant cell tumour of bone.
Patients and methods
Serum acid phosphatase levels were measured in 32 patients with this tumour both preoperatively and postoperatively.
Results
Serum acid phosphatase value before surgery was high in 15 patients, whereas it was within normal limits in 17 patients. The serum acid phosphatase values of all the 15 patients with high preoperative serum level fell within normal limits postoperatively. In the remaining 17 patients in whom preoperative serum acid phosphatase values were within normal limits, postoperative serum acid phosphatase levels were lower than that of preoperative ones in all the patients. In addition, there was a statistically significant positive correlation between the tumour volume and the preoperative serum acid phosphatase level.
Conclusion
It is concluded that serum acid phosphatase is a useful tumour marker for giant cell tumour of bone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ores R, Rosen P, Ortiz J (1969) Localization of acid phosphatase activity. In a giant cell tumor of bone. Arch Pathol 88:54–57
Schajowicz F (1961) Giant-cell tumors of bone (osteoclastoma). A pathological and histochemical study. J Bone Joint Surg Am 43:1–29
Thiéry JP, Mazabraud A, Voisin MC et al (1975) Étude cytologique de la tumeur à cellules géantes. Microscopie électronique et cyto-enzymologie. Rev Chir Orthop Repar Appar Mot 61:377–386
Goto T, Iijima T, Kawano H et al (2001) Serum acid phosphatase as a tumour marker in giant cell tumour of bone. Arch Orthop Trauma Surg 121:411–413. doi:10.1007/s004020000240
Lam K-W, Li C-Y, Yam LT et al (1982) Comparison of prostatic and nonprostatic acid phosphatase. Ann N Y Acad Sci 390:1–15. doi:10.1111/j.1749-6632.1982.tb40300.x
Bull H, Murray PG, Thomas D et al (2002) Acid phosphatases. Mol Pathol 55:65–72. doi:10.1136/mp.55.2.65
Chen J, Yam LT, Janckila AJ et al (1979) Significance of “high” acid phosphatase activity in the serum of normal children. Clin Chem 25:719–722
Henneberry MO, Engel G, Grayhack JT (1979) Acid phosphatase. Urol Clin North Am 6:629–641
Fishman WH, Lerner F (1953) A method for estimating serum acid phosphatase of prostatic origin. J Biol Chem 200:89–97
Desoize B, Veiler V, Pourny C et al (1989) Isoenzymes of alkaline and acid phosphatases as bone metastasis marker in breast cancer patients. Anticancer Res 9:1105–1110
Desoize B, Amico S, Larbre H et al (1991) Phosphatase isoenzymes as bone metastasis markers in prostatic carcinoma. Clin Biochem 24:443–446. doi:10.1016/S0009-9120(05)80021-9
Lam K-W, Dannaher C, Letchford S et al (1984) Tartrate-resistant acid phosphatase in serum of cancer patients. Clin Chem 30:457–459
Tavassoli M, Rizo M, Yam LT (1980) Elevation of serum acid phosphatase in cancers with bone metastasis. Cancer 45:2400–2403. doi:10.1002/1097-0142(19800501)45:9<2400::AID-CNCR2820450927>3.0.CO;2-N
Akahane T, Isobe K, Shimizu T (2005) Serum total acid phosphatase for monitoring the clinical course of giant cell tumors of bone: 26 patients with 5 local recurrences. Acta Orthop 76:651–653. doi:10.1080/17453670510041727
Acknowledgment
This study was partly funded by the Tokyo Metropolitan Clinical Research Grant.
Conflict of interest statement
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Goto, T., Kawano, H., Akiyama, T. et al. Serum acid phosphatase can be a useful tumour marker for giant cell tumour of bone. Arch Orthop Trauma Surg 129, 1641–1644 (2009). https://doi.org/10.1007/s00402-009-0858-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00402-009-0858-0