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Migratory potential of transplantable neural tumor cell lines

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Abstract

Experimentally induced primitive neuroectodermal tumor (PNET) cell lines were transplanted into neonatal and adult rat brain and examined neuropathologically for their tumorigenic potential. Both cell lines showed a striking migratory behavior in both neonatal and adult brain. Migration of tumor cells was found in host brain parenchyma, along white matter tracts and associated with CSF pathways. These neural tumor cell lines provide a valuable tool for the development of strategies against strongly migrating neural tumors.

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Authors and Affiliations

  1. Department of Psychiatry, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany e-mail: bayer@uni-bonn.de, Tel.: +49-228-287-6122, Fax: +49-228-287-6369, , , , , , DE

    T. A. Bayer

  2. Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany, , , , , , DE

    Sascha Weggen & Otmar D. Wiestler

  3. Institute of Neuropathology, RWTH Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany, , , , , , DE

    Michael Thier & Joachim Weis

  4. Department of Medicine, RWTH Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany, , , , , , DE

    Elke Roeb & Bettina Breuer

Authors
  1. T. A. Bayer
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  2. Michael Thier
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  3. Elke Roeb
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  4. Bettina Breuer
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  5. Sascha Weggen
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  6. Otmar D. Wiestler
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  7. Joachim Weis
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Additional information

Received: 22 June 1998 / Revised: 5 November 1998, 30 November 1998 / Accepted: 30 November 1998

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Bayer, T., Thier, M., Roeb, E. et al. Migratory potential of transplantable neural tumor cell lines. Acta Neuropathol 97, 607–612 (1999). https://doi.org/10.1007/s004010051036

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  • DOI: https://doi.org/10.1007/s004010051036

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