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Neurofilament H immunoreaction in oligodendrogliomas as demonstrated by a new polyclonal antibody

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Abstract

We have characterized a new polyclonal antibody against heavy chain (H) of neurofilament which can be used to demonstrate neurofilament H in normal brain tissue and oligodendroglioma cells immunocytochemically and immunochemically. Using this antibody we found neurofilament H-immunoreactive tumor cells in 13 oligodendrogliomas (6 WHO grade II, 7 WHO grade III) out of 84 oligodendrogliomas investigated (59 WHO grade II and 25 WHO grade III). Double immunolabeling and confocal laser scanning microscopy showed colocalization of neurofilament H and glial fibrillary acidic protein in certain oligodendroglioma cells. Colocalization of neurofilament and synaptophysin was observed only rarely. The results support the notion that oligodendrogliomas consists of a heterogeneous cell population displaying various stages of differentiation and dedifferentiation. The occurrence of neurofilament H-immunoreactive tumor cells in oligodendrogliomas is not related to the survival of the patients.

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Authors and Affiliations

  1. Dr. Senckenbergische Anatomie, Anatomisches Institut II, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany e-mail: korf@em.uni-frankfurt.de, Tel.: +49-69-63016040, Fax: +49-69-63016017, , , , , , DE

    F. Dehghani, E. Maronde & H.-W. Korf

  2. Institut für Neuropathologie, Justus-Liebig-Universität, Arndtstrasse 16, 35392 Giessen, Germany, , , , , , DE

    W. Schachenmayr

Authors
  1. F. Dehghani
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  2. E. Maronde
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  3. W. Schachenmayr
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  4. H.-W. Korf
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Received: 9 September 1999 · Revised, accepted: 15 October 1999

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Dehghani, F., Maronde, E., Schachenmayr, W. et al. Neurofilament H immunoreaction in oligodendrogliomas as demonstrated by a new polyclonal antibody. Acta Neuropathol 100, 122–130 (2000). https://doi.org/10.1007/s004010050003

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  • DOI: https://doi.org/10.1007/s004010050003

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