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Infratentorial C11orf95-fused gliomas share histologic, immunophenotypic, and molecular characteristics of supratentorial RELA-fused ependymoma

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References

  1. Andreiuolo F, Varlet P, Tauziede-Espariat A, Junger ST, Dorner E, Dreschmann V et al (2019) Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features. Brain Pathol 29:205–216. https://doi.org/10.1111/bpa.12659

    Article  CAS  PubMed  Google Scholar 

  2. Cavalli FMG, Hubner JM, Sharma T, Luu B, Sill M, Zapotocky M et al (2018) Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathol 136:227–237. https://doi.org/10.1007/s00401-018-1888-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C et al (2019) Septal dysembryoplastic neuroepithelial tumor: a comprehensive clinical, imaging, histopathologic, and molecular analysis. Neuro Oncol 21:800–808. https://doi.org/10.1093/neuonc/noz037

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ellison DW, Aldape KD, Capper D, Fouladi M, Gilbert MR, Gilbertson RJ et al (2020) cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors. Brain Pathol. https://doi.org/10.1111/bpa.12866

    Article  PubMed  Google Scholar 

  5. Pajtler KW, Wen J, Sill M, Lin T, Orisme W, Tang B et al (2018) Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. Acta Neuropathol 136:211–226. https://doi.org/10.1007/s00401-018-1877-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F et al (2015) Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell 27:728–743. https://doi.org/10.1016/j.ccell.2015.04.002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y et al (2014) C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma. Nature 506:451–455. https://doi.org/10.1038/nature13109

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R et al (2011) Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell 20:143–157. https://doi.org/10.1016/j.ccr.2011.07.007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, 38105-3678, USA

    Camille Keenan, Richard T. Graham, Santhosh A. Upadhyaya & Anna Vinitsky

  2. Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA

    Julie H. Harreld

  3. Department of Radiation Oncology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA

    John T. Lucas Jr.

  4. Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA

    David Finkelstein, David Wheeler & Jinghui Zhang

  5. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, 38105-3678, USA

    Xiaoyu Li, James Dalton, Susana C. Raimondi, Lu Wang & Jason Chiang

  6. Department of Surgery, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA

    Frederick A. Boop & Michael DeCuypere

  7. Department of Pathology, St. Jude Children’s Research Hospital, MS 250, Room C5024A, 262 Danny Thomas Place, Memphis, TN, 38105-3678, USA

    Jason Chiang

Authors
  1. Camille Keenan
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  2. Richard T. Graham
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  5. David Finkelstein
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  6. David Wheeler
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  7. Xiaoyu Li
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  8. James Dalton
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  9. Santhosh A. Upadhyaya
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  10. Susana C. Raimondi
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  11. Frederick A. Boop
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  12. Michael DeCuypere
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  13. Jinghui Zhang
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  14. Anna Vinitsky
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  15. Lu Wang
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  16. Jason Chiang
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Corresponding authors

Correspondence to Anna Vinitsky, Lu Wang or Jason Chiang.

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Keenan, C., Graham, R.T., Harreld, J.H. et al. Infratentorial C11orf95-fused gliomas share histologic, immunophenotypic, and molecular characteristics of supratentorial RELA-fused ependymoma. Acta Neuropathol 140, 963–965 (2020). https://doi.org/10.1007/s00401-020-02238-3

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  • DOI: https://doi.org/10.1007/s00401-020-02238-3

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