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Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker

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References

  1. Feller C, Felix M, Weiss T, Herold-Mende C, Zhang F, Kockmann T et al (2019) Histone epiproteomic profiling distinguishes oligodendroglioma, IDH-mutant and 1p/19q co-deleted from IDH-mutant astrocytoma and reveals less tri-methylation of H3K27 in oligodendrogliomas. Acta Neuropathol. https://doi.org/10.1007/s00401-019-02096-8. (Epub ahead of print)

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Acknowledgements

This study was funded in part by the UCSF Department of Pathology (M.P.), NIH/NCI U01 (CA229345, J.J.P.) and NIH Director’s Early Independence Award (DP5 OD021403, D.A.S.).

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Authors and Affiliations

  1. Department of Pathology, University of California, San Francisco (UCSF), 505 Parnassus Ave, Room M551, San Francisco, CA, 94143, USA

    Melike Pekmezci, Joanna J. Phillips, Tarik Tihan, David Solomon, Andrew Bollen & Arie Perry

  2. Department of Neurological Surgery, University of California, San Francisco (UCSF), San Francisco, CA, USA

    Joanna J. Phillips & Arie Perry

  3. Department of Pathology, Faculty of Medicine, Near East University, Nicosia, Cyprus

    Fikret Dirilenoglu

  4. Department of Pathology, Atatürk Eğitim ve Araştırma Hastanesi (EAH), İzmir Katip Çelebi Üniversitesi (KCU), Izmir, Turkey

    Fikret Dirilenoglu & Turkan Atasever-Rezanko

  5. Department of Pathology, Gaziosmanpaşa Hastanesi, Yeni Yüzyıl Üniversitesi, Izmir, Turkey

    Turkan Atasever-Rezanko

Authors
  1. Melike Pekmezci
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  2. Joanna J. Phillips
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  3. Fikret Dirilenoglu
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  4. Turkan Atasever-Rezanko
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  5. Tarik Tihan
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  6. David Solomon
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  7. Andrew Bollen
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  8. Arie Perry
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Correspondence to Melike Pekmezci.

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Pekmezci, M., Phillips, J.J., Dirilenoglu, F. et al. Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker. Acta Neuropathol 139, 597–600 (2020). https://doi.org/10.1007/s00401-019-02123-8

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  • DOI: https://doi.org/10.1007/s00401-019-02123-8

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