References
Ceccom J, Bourdeaut F, Loukh N et al (2014) Embryonal tumor with multilayered rosettes: diagnostic tools update and review of the literature. Clin Neuropathol 33:15–22
Deisch J, Raisanen J, Rakheja D (2011) Immunohistochemical expression of embryonic stem cell markers in malignant rhabdoid tumors. Pediatr Dev Pathol 14:353–359
Eberhart CG, Brat DJ, Cohen KJ, Burger PC (2000) Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr Dev Pathol 3:346–352
Gessi M, Giangaspero F, Lauriola L et al (2009) Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol 33:211–217
Judkins AR, Ellison D (2010) Ependymoblastoma: dear, damned, distracting diagnosis, farewell! Brain Pathol 20:133–139
Kleinman CL, Gerges N, Papillon-Cavanagh S et al (2014) Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nat Genet 46:39–44
Korshunov A, Remke M, Gessi M et al (2010) Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol 120:253–260
Korshunov A, Ryzhova M, Jones DT et al (2012) LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). Acta Neuropathol 124:875–881
Korshunov A, Sturm D, Ryzhova M (2014) Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol (in press)
Lafay-Cousin L, Hader W, Wei XC et al (2014) Post-chemotherapy maturation in supratentorial primitive neuroectodermal tumors. Brain Pathol 24:166–172
Li M, Lee KF, Lu Y et al (2010) Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell 16:533–546
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2007) WHO classification of tumors of the central nervous system, 4th edn. International Agency for Research on Cancer, Lyon
Louis DN, Perry A, Burger PC et al (2014) International Society of Neuropathology-Haarlem consensus guidelines for nervous system tumor classification and grading. Brain Pathol. doi:10.1111/bpa.12171
Mao XG, Hütt-Cabezas M, Orr BA et al (2013) LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program. Oncotarget 4:1050–1064
Nobusawa S, Yokoo H, Hirato J et al (2012) Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes. Brain Pathol 22:689–697
Paulus W, Kleihues P (2010) Genetic profiling of CNS tumors extends histological classification. Acta Neuropathol 120:269–270
Picard D, Miller S, Hawkins CE et al (2012) Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis. Lancet Oncol 13:838–848
Pfister S, Remke M, Castoldi M et al (2009) Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol 117:457–464
Spence T, Perotti C, Sin-Chan P et al (2014) A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes. Neuro Oncol 16:62–71
Spence T, Sin-Chan P, Picard D (2014) CNS-PNETs with C19M/C amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. Acta Neuropathol (in press)
Taylor MD, Northcott PA, Korshunov A et al (2012) Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 123:465–472
Wang Y, Chu SG, Xiong J et al (2011) Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with a focal amplification at chromosome 19q13.42 locus: further evidence of two new instances in China. Neuropathology 31:639–647
Woehrer A, Slavc I, Peyrl A et al (2011) Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with loss of morphological but retained genetic key features during progression. Acta Neuropathol 122:787–790
Zhu H, Shyh-Chang N, Segrè AV et al (2011) The Lin28/let-7 axis regulates glucose metabolism. Cell 147:81–94
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wesseling, P. Embryonal tumor with multilayered rosettes (ETMR): signed, sealed, delivered …. Acta Neuropathol 128, 305–308 (2014). https://doi.org/10.1007/s00401-014-1320-0
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00401-014-1320-0