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Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYClowBCL2low subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas

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Acknowledgments

The expert technical assistance of Elena Fischer, Ursula Schnaidt, and Reina Zühlke-Jenisch is greatly acknowledged. This study was supported by the Deutsche Krebshilfe/Dr. Mildred-Scheel Stiftung für Tumorforschung (Grant No.: 109471) and the Wilhelm-Sander-Stiftung (2011.092.1).

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Authors and Affiliations

  1. Department of Neuropathology, University Hospital of Cologne, Kerpener Str. 62, 50924, Cologne, Germany

    Anna Brunn, Manuel Montesinos-Rongen & Martina Deckert

  2. Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig–Holstein, Campus Kiel, Kiel, Germany

    Inga Nagel, Inga Vater & Reiner Siebert

  3. Institute of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig–Holstein, Campus Kiel, Kiel, Germany

    Wolfram Klapper

  4. Institute of Neuropathology, University Hospital Münster, Münster, Germany

    Werner Paulus

  5. Department of Neuropathology, Evangelisches Krankenhaus, Bielefeld, Germany

    Volkmar Hans

  6. Department of Neuropathology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

    Ingmar Blümcke

  7. Department of Neuropathology, University Hospital Aachen, Aachen, Germany

    Joachim Weis

Authors
  1. Anna Brunn
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  2. Inga Nagel
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  3. Manuel Montesinos-Rongen
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  4. Wolfram Klapper
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  5. Inga Vater
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  6. Werner Paulus
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  7. Volkmar Hans
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  8. Ingmar Blümcke
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  9. Joachim Weis
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  10. Reiner Siebert
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  11. Martina Deckert
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Corresponding author

Correspondence to Martina Deckert.

Additional information

A. Brunn and I. Nagel contributed equally to the work.

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Brunn, A., Nagel, I., Montesinos-Rongen, M. et al. Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYClowBCL2low subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas. Acta Neuropathol 126, 603–605 (2013). https://doi.org/10.1007/s00401-013-1169-7

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  • DOI: https://doi.org/10.1007/s00401-013-1169-7

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