References
Bettegowda C, Agrawal N, Jiao Y et al (2011) Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 333:1453–1455
Broderick DK, Di C, Parrett TJ, Samuels YR, Cummins JM, McLendon RE, Fults DW, Velculescu VE, Bigner DD, Yan H (2004) Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res 64:5048–5050
Broniscer A, Baker SJ, West AN et al (2007) Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol 25:682–689
Gessi M, Waha A, Setty P, Pietsch T (2011) Analysis of KIAA1549–BRAF fusion status in a case of rosette-forming glioneuronal tumor of the fourth ventricle (RGNT). Neuropathology. doi:10.1111/j.1440-1789.2011.01220.x
Hainfellner JA, Scheithauer BW, Giangaspero F, Rosenblum MK (2007) Rosette-forming glioneuronal tumour of the fourth ventricle. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system, 4th edn. International Agency for Research on Cancer, Lyon, pp 115–116
Hartmann C, Bartels G, Gehlhaar C, Holtkamp N, von Deimling A (2005) PIK3CA mutations in glioblastoma multiforme. Acta Neuropathol 109:639–642
Hartmann C, Devermann L, Gehlhaar C, Holtkamp N, von Deimling A (2006) PIK3CA mutations in oligodendroglial tumours. Neuropathol Appl Neurobiol 32:209–212
Jacques TS, Eldridge C, Patel A, Saleem NM, Powell M, Kitchen ND, Thom M, Revesz T (2006) Mixed glioneuronal tumour of the fourth ventricle with prominent rosette formation. Neuropathol Appl Neurobiol 32:217–220
Koul D (2008) PTEN signaling pathways in glioblastoma. Cancer Biol Ther 7:1321–1325
Rodriguez EF, Scheithauer BW, Giannini C, Rynearson A, Cen L, Hoesley B, Gilmer-Flynn H, Sarkaria JN, Jenkins S, Long J, Rodriguez FJ (2011) PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma. Acta Neuropathol 121:407–420
Samuels Y, Wang Z, Bardelli A et al (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304:554
Sasaki H, Zlatescu MC, Betensky RA, Ino Y, Cairncross JG, Louis DN (2001) PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. Am J Pathol 159:359–367
Schindler G, Capper D, Meyer J et al (2011) Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 121:397–405
Thomas RK, Baker AC, DeBiasi RM et al (2007) High-throughput oncogene mutation profiling in human cancer. Nat Genet 39:347–351
Wick W, Weller M, Weiler M, Batchelor T, Yung AW, Platten M (2011) Pathway inhibition: emerging molecular targets for treating glioblastoma. Neuro Oncol 13:566–579
Acknowledgments
We would like to thank Bedia Barkoh from MDACC’s Molecular Diagnostic laboratory for technical assistance with Sequenom™ testing and Vidya Mehta from Texas Children’s Hospital for FISH testing.
Author information
Authors and Affiliations
Corresponding author
Additional information
B. Ellezam and B. J. Theeler contributed equally to the work.
Rights and permissions
About this article
Cite this article
Ellezam, B., Theeler, B.J., Luthra, R. et al. Recurrent PIK3CA mutations in rosette-forming glioneuronal tumor. Acta Neuropathol 123, 285–287 (2012). https://doi.org/10.1007/s00401-011-0886-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00401-011-0886-z