Abstract.
The inferior olivary nucleus (ION) from nine patients with multiple system atrophy was examined with antibodies against α-synuclein, ubiquitin, synaptophysin, glial fibrillary acidic protein, the Golgi apparatus (GA)-trans-Golgi network (TGN), and microglia/macrophages. As previously reported, there were neuronal loss, gliosis, and α-synuclein-positive cytoplasmic inclusions in neurons and glia. In addition, all neurons with α-synuclein-positive cytoplasmic inclusions contained abnormal profiles of the GA and TGN, which were reduced in size and numbers. This finding suggests a relationship between the pathogenetic mechanisms causing inclusion body formation and abnormalities of the GA-TGN. This study is also consistent with the conclusion that lesions of the ION may not always reflect changes of transsynaptic degeneration secondary to Purkinje cell loss.
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Revised, accepted: 6 November 2001
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Sakurai, A., Okamoto, K., Yaguchi, M. et al. Pathology of the inferior olivary nucleus in patients with multiple system atrophy. Acta Neuropathol 103, 550–554 (2002). https://doi.org/10.1007/s00401-001-0500-x
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DOI: https://doi.org/10.1007/s00401-001-0500-x