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The influence of temperature on rheological properties of blood mixtures with different volume expanders—implications in numerical arterial hemodynamics simulations

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Abstract

During the complicated cardiac surgery on a non-beating heart with cardiopulmonary bypass, protection of the heart is accomplished by injecting cold cardioplegic solutions. In most forms of circulatory shock, it is necessary to immediately restore the circulating volume. Intravenous solutions of volume expanders, such as hydroxyethyl starch and dextrans, are used to increase the volume of fluid in the circulating blood. In this work, blood samples of six donors were obtained and used to prepare mixtures with different volume expanders in concentrations ranging from 10 to 50 vol./vol.%. The flow curves of all mixtures in the temperature range from 4°C to 37°C were constructed and fitted to the Herschel–Bulkley model, in order to extract the shear thinning and yield stress parameters. To assess the influence of the observed changes in the rheological properties of blood on the hemodynamics in arterial vasculature, a realistic three-dimensional rigid-wall computational model was constructed from MRI images of the right carotid bifurcation obtained in vivo from a healthy male volunteer. The time-varying flow field was numerically computed using the Newtonian model as well as the Herschel–Bulkley model with the Papanastasiou regularization. The numerical simulations indicate only moderate changes in the time-averaged flow field that become accentuated when the instantaneous flow field is considered. We also found that although the influence of temperature, hematocrit, and volume expanders on hemodynamics is significant, this can primarily be attributed to the changes in the nominal viscosity of the flow medium.

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Acknowledgements

The project was partially funded by two Cyprus–Slovenia grants from the Cyprus Research Promotion Foundation and the Slovenia Research Agency (Projects CY-SLO/0407/05 and CY-SLO/0609/01).

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Authors and Affiliations

  1. Department of Chemical, Biochemical and Environmental Engineering, University of Ljubljana, Askerceva 5, Sl-1000, Ljubljana, Slovenia

    Andreja Zupančič Valant

  2. Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Korytkova 2, Sl-1000, Ljubljana, Slovenia

    Lovro Žiberna

  3. Foundation for Research and Technology Hellas (FORTH), Institute of Applied and Computational Mathematics, PO Box 1527, 71110, Heraklion, Crete, Greece

    Yannis Papaharilaou

  4. Department of Mechanical Engineering and Materials Science and Engineering, Cyprus University of Technology, Limassol, 3503, Cyprus

    Andreas Anayiotos

  5. Department of Mathematics and Statistics, University of Cyprus, PO Box 20537, 1678, Nicosia, Cyprus

    Georgios C. Georgiou

Authors
  1. Andreja Zupančič Valant
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  2. Lovro Žiberna
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  3. Yannis Papaharilaou
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  4. Andreas Anayiotos
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  5. Georgios C. Georgiou
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Correspondence to Andreja Zupančič Valant.

Additional information

Paper presented at Workshop on Viscoplastic Fluids: from Theory to Applications. November 1–5, Limassol, Cyprus.

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Zupančič Valant, A., Žiberna, L., Papaharilaou, Y. et al. The influence of temperature on rheological properties of blood mixtures with different volume expanders—implications in numerical arterial hemodynamics simulations. Rheol Acta 50, 389–402 (2011). https://doi.org/10.1007/s00397-010-0518-x

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  • DOI: https://doi.org/10.1007/s00397-010-0518-x

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