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Synthesis and characterization of silver and copper metal–organic hybrid nanomaterials and their biological application

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Abstract

Different types of hybrid organic–inorganic compounds were investigated as antibacterial agents. These compounds have exhibited reasonable antibacterial activity with lower cytotoxicity. Herein, compounds [Ag6(MBT)6] (1) and [Cu6(MBT)6] (2) (HMBT: 2-mercaptobenzothiazole) were synthesized by using the reflux method (1b, 2b) and sonochemical process (1s, 2s). The obtained products were characterized by powder X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, and scanning electron microscopy. Then, their antibacterial activity was investigated by using the agar well diffusion method, and the results were reported by inhibition zone diameter. The results showed that nanosized samples were more active against bacteria because of their higher surface area. These two compounds showed different antibacterial activities, and the silver-based complex is a better antibacterial agent against both strains of bacteria which is attributed to the different mechanisms of Ag(I) and Cu(I) ions in antimicrobial action. They also showed a reasonable antibacterial effect that was comparable to other types of hybrid organic–inorganic compounds.

The antimicrobial effect of two polynuclear complexes from Ag and Cu is investigated. They have different antibacterial activities. Ag(I) and Cu(I) ions have different mechanism in antimicrobial action. Their antibacterial effect was comparable to other types of metal complexes.

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Funding

The authors would like to acknowledge the financial support of the University of Tehran for this research under grant number 01/1/389845.

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Authors and Affiliations

  1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

    Mojdeh Nakhaei & Kamran Akhbari

  2. Department of Materials Science and Technology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand

    Anukorn Phuruangrat

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  1. Mojdeh Nakhaei
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  2. Kamran Akhbari
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Correspondence to Kamran Akhbari.

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Nakhaei, M., Akhbari, K. & Phuruangrat, A. Synthesis and characterization of silver and copper metal–organic hybrid nanomaterials and their biological application. Colloid Polym Sci 299, 773–781 (2021). https://doi.org/10.1007/s00396-020-04788-0

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