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Synthesis and characterization of hyperbranched copolymers hyper-g-(NIPAAm-co-IAM) via ATRP

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Abstract

A hyperbranched copolymer, hyperbranched-g-(N-isopropylacrylamide-co-itaconamic acid) (“hyperbranch-g-(NIPAAm-co-IAM)”), serving as a pH- and thermo-responsive material, was synthesized via atomic transfer radical polymerization (ATRP) and characterized in this study. A macroinitiator was prepared from a commercially available hyperbranched polymer, “hyperbranched bis-(methylol)propionic acid (bis-MPA) polyester-16-hydroxyl, generation 2” (hyperbranch-OH) and used as a core structure of the hyperbranched copolymer. The hyperbranch-OH has 16 hydroxyl groups; among them, 12 arms were derived from substitution of the hydroxyl groups with poly(NIPAAm-co-IAM) by ATRP. The polydispersity index (PDI) of the newly synthesized hyperbranched copolymer can be controlled to be less than 1.4. The hyperbranched copolymer shows more significant size change as the environmental pH value changes, compared to the linear random poly(NIPAAm-co-IAM). The particle size decreases with temperature but increases with the pH value. As the molar fraction of IAM in the hyperbranched copolymer increases, the lower critical solution temperature (LCST) increases. Hyperbranch-g-(NIPAAm-co-IAM) with a molar ratio of NIPAAm/IAM equaling to 3:1 shows a LCST of the aqueous solution close to the body temperature, indicating potential use in biomedical applications such as drug release.

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Acknowledgments

The authors would like to thank the National Science Council of the Republic of China, Taiwan, for financially supporting this research under Contract No. NSC 102-2218-E-027-015.

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Authors and Affiliations

  1. Institute of Organic and Polymeric Materials, National Taipei University of Technology, #1, Sec 3, Chung-Hsiao E. Rd, Taipei, Taiwan, ROC

    Syang-Peng Rwei, Kuei-Ting Shu, Shu-Mei Chang, Whe-Yi Chiang & Wei-Chu Pan

  2. Material and Chemical Research Laboratories, Industrial Technology Research Institute, Taiwan, ROC

    Tun-Fun Way

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  1. Syang-Peng Rwei
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  2. Kuei-Ting Shu
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Correspondence to Syang-Peng Rwei.

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Rwei, SP., Shu, KT., Way, TF. et al. Synthesis and characterization of hyperbranched copolymers hyper-g-(NIPAAm-co-IAM) via ATRP. Colloid Polym Sci 294, 291–301 (2016). https://doi.org/10.1007/s00396-015-3775-5

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  • DOI: https://doi.org/10.1007/s00396-015-3775-5

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