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Silica particles coated with azobenzene-containing photoresponsive molecule-imprinted skin layer

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Abstract

We developed a novel type of azobenzene-containing photoresponsive molecule-imprinted silica microspheres. Ibuprofen and activated silica particles were used as template molecules and substrates, respectively. Pre-synthesized azobenzene-based monomers were chemically bonded on the surface of silica particles. Template–monomer complexes were formed relying on hydrogen bonding. Then skin layer was formed by graft polymerization of azobenzene-based monomers. After that, ibuprofen molecules were removed from their embedded spaces. The vacant spaces on the surface of particles were easily accessible for the template molecules. Furthermore, photoinduced trans–cis isomerization of azobenzene chromophores within imprinted vacant spaces was able to regulate their substrate affinity. The results demonstrated that the imprinted silica microspheres possessed obvious molecular imprinting effects towards the template ibuprofen, rather fast template rebinding kinetics, and appreciate selectivity over structurally related compounds.

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Acknowledgments

The authors are grateful for the financial support from National Natural Science Foundation of China (21276283).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, China, 410083

    Cui-E Li, Shi-An Zhong, Xiao-Jing Li & Meng Guo

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  1. Cui-E Li
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  2. Shi-An Zhong
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  3. Xiao-Jing Li
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  4. Meng Guo
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Correspondence to Shi-An Zhong.

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Li, CE., Zhong, SA., Li, XJ. et al. Silica particles coated with azobenzene-containing photoresponsive molecule-imprinted skin layer. Colloid Polym Sci 291, 2049–2059 (2013). https://doi.org/10.1007/s00396-013-2944-7

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  • DOI: https://doi.org/10.1007/s00396-013-2944-7

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