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Effects of precipitate agents on temperature-responsive sol–gel transitions of PLGA–PEG–PLGA copolymers in water

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Abstract

This paper reports the effects of precipitate agents used in the collection of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. We synthesized PLGA–PEG–PLGA triblock copolymers with a relatively wide distribution of molecular weight (MW) and then separated the crude polymers via three different precipitate agents (diethyl ether, hexane, or methanol). The obtained products exhibited, however, significantly different macroscopic states in water: some were sols, some were precipitates, and some underwent sol–gel transition upon heating. We found that by using different precipitate agents, ingredients of different MW were collected from the synthesized polymers, which accounted for the different states of the separated products in water. Our study strengthens the importance of an appropriate precipitate agent and reveals the subtle balance of hydrophobicity and hydrophilicity in this sort of amphiphilic block copolymers.

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Acknowledgments

The group was supported by the Chinese Ministry of Science and Technology (973 Program No. 2009CB930000), NSF of China (Grants No. 20774020 and No. 50903021), Science and Technology Developing Foundation of Shanghai (Grants No. 074319117 and No. 09ZR1403700), the Specialized Research Fund for the Doctoral Program of Higher Education of China (SRFDP; No. 20090071120014), and Shanghai Education Committee (Project No. B112).

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Authors and Affiliations

  1. Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Advanced Materials Laboratory, Fudan University, Shanghai, 200433, China

    Lin Yu, Huan Zhang & Jiandong Ding

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  1. Lin Yu
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  2. Huan Zhang
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  3. Jiandong Ding
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Correspondence to Jiandong Ding.

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Yu, L., Zhang, H. & Ding, J. Effects of precipitate agents on temperature-responsive sol–gel transitions of PLGA–PEG–PLGA copolymers in water. Colloid Polym Sci 288, 1151–1159 (2010). https://doi.org/10.1007/s00396-010-2246-2

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  • DOI: https://doi.org/10.1007/s00396-010-2246-2

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