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Colloid and Polymer Science

, 287:1295 | Cite as

Polypeptide hybrid copolymers as selective micellar nanocarriers in nonaqueous media

  • Guillermo Orts Gil
  • Sylvain Prévost
  • Magdalena Łosik
  • Florian Hermes
  • Helmut SchlaadEmail author
  • Thomas HellwegEmail author
Original Contribution

Abstract

The self-assembly of polystyrene-block-poly(l-lysine) (PS-PLLys·HCl) copolymers with different block lengths has been studied in toluene. The obtained spherical micelles exhibit size variations upon addition of acids or bases, as indicated by light and neutron scattering studies. It is shown that pyridine induces a shrinking of the polystyrene chains in the corona region of the micelles, decreasing the aggregate solvent interface. The addition of benzoic acid, on the other hand, leads to a swelling of the copolymer micelles proportional to the molar fraction of polypeptide. This behavior suggests a selective permeability of the PS-PLLys micelles and the possibility to encapsulate organic compounds in toluene depending on their chemical nature.

Keywords

Block copolymer Biohybrid SANS DLS 

Notes

Acknowledgments

We wish to thank the DFG (Sfb 448, TP A12, and BIOSONS) for financial support. T.H. also would like to acknowledge financial support from the Sfb 481 (TP A15).

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Guillermo Orts Gil
    • 1
    • 5
  • Sylvain Prévost
    • 1
    • 3
  • Magdalena Łosik
    • 2
  • Florian Hermes
    • 2
  • Helmut Schlaad
    • 2
    Email author
  • Thomas Hellweg
    • 4
    Email author
  1. 1.Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für ChemieTechnische Universität BerlinBerlinGermany
  2. 2.Max-Planck-Institut für Kolloid-und GrenzflächenforschungWissenschaftspark GolmPotsdamGermany
  3. 3.Helmholtz-Zentrum-BerlinBerlinGermany
  4. 4.Universität Bayreuth, Physikalische Chemie I, Universitätsstr. 30BayreuthGermany
  5. 5.Bundesanstalt für Materialforschung und -prüfung (BAM), Unter den Eichen 87BerlinGermany

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