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Synthesis of biocompatible and biodegradable polymer particles in supercritical carbon dioxide

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Abstract

The free radical copolymerization of N-vinyl-2-pyrrolidone and 2-methylene-1,3-dioxepane was carried out in supercritical carbon dioxide (scCO2) using three kinds of dispersants and 2,2′-azobisisobutyronitrile as the initiator. Polymerization was performed with fluorinated polymeric dispersants synthesized in scCO2 using the solution polymerization method and commercially available siloxane-based surfactant. Spherical biocompatible and biodegradable polymeric particles were prepared within the sub-micron size range. The effect of various ratios of the comonomer, reaction temperature, and concentration of initiator, in addition to the types and concentrations of the dispersants, on the particle size and morphology was investigated. The particle size and particle size distribution of copolymer particles were controlled using the above mentioned experimental parameters. Glass transition temperatures of copolymers were varied according to the comonomer ratios used.

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Acknowledgments

This work was supported by the Industry & Energy and the Energy Management Corporation, the BK21 project of the Ministry of Education, and the National Research Laboratory (NRL) Program of the Korea Institute of Science & Technology Evaluation and Planning.

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Authors and Affiliations

  1. School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Gwanak-599, Gwanak-ro, Seoul, 151-744, Korea

    Soyoung Kwon, Kyoungwon Lee, Hwayong Kim & Youn-Woo Lee

  2. R&D Institute, Miwon Commercial Co., Ltd, Ansan, 425-100, Korea

    Won Bae

Authors
  1. Soyoung Kwon
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  2. Kyoungwon Lee
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  3. Hwayong Kim
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  4. Youn-Woo Lee
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  5. Won Bae
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Correspondence to Youn-Woo Lee.

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Kwon, S., Lee, K., Kim, H. et al. Synthesis of biocompatible and biodegradable polymer particles in supercritical carbon dioxide. Colloid Polym Sci 286, 1181–1191 (2008). https://doi.org/10.1007/s00396-008-1888-9

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  • DOI: https://doi.org/10.1007/s00396-008-1888-9

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