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Probing the micellization of diblock and triblock copolymers of poly(l-lactide) and poly(ethylene glycol) in aqueous and NaCl salt solutions

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Abstract

The micelle formation of a series of amphiphilic block copolymers in aqueous and NaCl solutions was studied by a fluorescent probe technique using pyrene as a "model drug". These copolymers were synthesized from poly (ethylene glycol) (PEG) and l-lactide by a new calcium ammoniate catalyst. They had fixed PEG block lengths (44, 104 or 113 ethylene oxide units) and various poly(l-lactide) (PLLA) block lengths (15-280 lactide units). The critical micelle concentration (cmc) was found to decrease with increasing PLLA content. The distinct dissimilarity of the cmc values of diblock and triblock copolymers based on the same block length of PEG provided evidence for the different configurations of their micelles. It was also observed that the introduction of NaCl salt significantly contributed to a decrease in the cmcs of the copolymers with short PEG and PLLA blocks, while it had less influence on the cmcs of copolymers with long PEG or PLLA blocks. The dependence of partition coefficients ranging from 0.2×105 to 1.9×105 on the PLLA content in the copolymer and on the micelle configuration was also discussed. The contribution of NaCl salt to increasing the partition of pyrene into a micellar phase was observed.

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Acknowledgement

The project was supported by the National Natural Science Foundation of China.

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Authors and Affiliations

  1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, Changchun, China

    Zhongli Dai, Longhai Piao, Xuefei Zhang, Mingxiao Deng, Xuesi Chen & Xiabin Jing

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  1. Zhongli Dai
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  2. Longhai Piao
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  3. Xuefei Zhang
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  4. Mingxiao Deng
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  5. Xuesi Chen
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  6. Xiabin Jing
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Correspondence to Xiabin Jing.

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Dai, Z., Piao, L., Zhang, X. et al. Probing the micellization of diblock and triblock copolymers of poly(l-lactide) and poly(ethylene glycol) in aqueous and NaCl salt solutions. Colloid Polym Sci 282, 343–350 (2004). https://doi.org/10.1007/s00396-003-0937-7

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  • DOI: https://doi.org/10.1007/s00396-003-0937-7

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