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Expression of the L-type calcium channel in human heart failure

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Basic Research in Cardiology Aims and scope Submit manuscript

Abstract

L-type calcium channels play an important role in excitation-contraction coupling. After cardiomyocyte depolarization L-type calcium channels open and Ca2+ ions enter the cell. These small Ca2+ inward currents trigger calcium release from the junctional sarcoplasmic reticulum, a process called calcium-induced calcium release. Subsequently, the cytosolic Ca2+ concentration rises rapidly to levels that initiate contraction. In heart failure calcium-induced calcium release is disturbed, and in this review we focus on the L-type calcium channel and its contribution to this defective excitation-contraction coupling.

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Authors and Affiliations

  1. Herzzentrum Leipzig, Klinik für Herzchirurgie, Russenstraße 19, 04289 Leipzig, Germany, , , , , , DE

    Joachim Hersel

  2. Schweizer Herz- und Gefäßzentrum Bern, Abteilung Kardiologie, Universitätsspital Bern – Inselspital, 3010 Bern, Switzerland, , , , , , CH

    Simon Jung, Paul Mohacsi & Roger Hullin

Authors
  1. Joachim Hersel
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  2. Simon Jung
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  3. Paul Mohacsi
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  4. Roger Hullin
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Hersel, J., Jung, S., Mohacsi, P. et al. Expression of the L-type calcium channel in human heart failure. Basic Res Cardiol 97 (Suppl 1), I4–I10 (2002). https://doi.org/10.1007/s003950200022

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  • DOI: https://doi.org/10.1007/s003950200022

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