Akhmerov A, Marban E (2020) COVID-19 and the heart. Circ Res. https://doi.org/10.1161/circresaha.120.317055
Article
PubMed
Google Scholar
Aminzadeh MA, Rogers RG, Fournier M, Tobin RE, Guan X, Childers MK, Andres AM, Taylor DJ, Ibrahim A, Ding X, Torrente A, Goldhaber JM, Lewis M, Gottlieb RA, Victor RA, Marbán E (2018) Exosome-mediated benefits of cell therapy in mouse and human models of duchenne muscular dystrophy. Stem Cell Rep 10:942–955. https://doi.org/10.1016/j.stemcr.2018.01.023
CAS
Article
Google Scholar
Aminzadeh MA, Tseliou E, Sun B, Cheng K, Malliaras K, Makkar RR, Marbán E (2015) Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy. Eur Heart J 36:751–762. https://doi.org/10.1093/eurheartj/ehu196
CAS
Article
PubMed
Google Scholar
Definition Task Force ARDS, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS (2012) Acute respiratory distress syndrome: the Berlin Definition. JAMA 307:2526–2533. https://doi.org/10.1001/jama.2012.5669
CAS
Article
Google Scholar
Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, Lee M (2020) Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State. JAMA. https://doi.org/10.1001/jama.2020.4326
Article
PubMed
PubMed Central
Google Scholar
Bonios M, Terrovitis J, Chang CY, Engles JM, Higuchi T, Lautamäki R, Yu J, Fox J, Pomper M, Wahl RL, Tsui BM, O'Rourke B, Bengel FM, Marbán E, Abraham MR (2011) Myocardial substrate and route of administration determine acute cardiac retention and lung bio-distribution of cardiosphere-derived cells. J Nucl Cardiol 18:443–450. https://doi.org/10.1007/s12350-011-9369-9
Article
PubMed
PubMed Central
Google Scholar
Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, Greninger AL, Pipavath S, Wurfel MM, Evans L, Kritek PA, West TE, Luks A, Gerbino A, Dale CR, Goldman JD, O'Mahony S, Mikacenic C (2020) Covid-19 in critically ill patients in the Seattle Region—case series. N Engl J Med. https://doi.org/10.1056/nejmoa2004500
Article
PubMed
PubMed Central
Google Scholar
Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X, Xia J, Chen N, Xiang J, Yu T, Bai T, Xie X, Zhang L, Li C, Yuan Y, Chen H, Li H, Huang H, Tu S, Gong F, Liu Y, Wei Y, Dong C, Zhou F, Gu X, Xu J, Liu Z, Zhang Y, Li H, Shang L, Wang K, Li K, Zhou X, Dong X, Qu Z, Lu S, Hu X, Ruan S, Luo S, Wu J, Peng L, Cheng F, Pan L, Zou J, Jia C, Wang J, Liu X, Wang S, Wu X, Ge Q, He J, Zhan H, Qiu F, Guo L, Huang C, Jaki T, Hayden FG, Horby PW, Zhang D, Wang C (2020) A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. https://doi.org/10.1056/nejmoa2001282
Article
PubMed
PubMed Central
Google Scholar
Cao X (2020) COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. https://doi.org/10.1038/s41577-020-0308-3
Article
PubMed
PubMed Central
Google Scholar
Centers for Disease Control and Prevention. Evaluating and Testing Persons for Coronavirus Disease 2019 (COVID-19). Available at: https://www.cdc.gov/coronavirus/2019-nCoV/hcp/clinical-criteria.html. Accessed 28 Apr 2020
Chakravarty T, Makkar RR, Ascheim DD, Traverse JH, Schatz R, DeMaria A, Francis GS, Povsic TJ, Smith RR, Lima JA, Pogoda JM, Marbán L, Henry TD (2017) Allogeneic heart stem cells to achieve myocardial regeneration (ALLSTAR) trial: rationale and design. Cell Transplant 26:205–214. https://doi.org/10.3727/096368916X692933
Article
PubMed
PubMed Central
Google Scholar
Chen J, Hu C, Chen L, Tang L, Zhu Y, Xu X, Chen L, Gao H, Lu X, Yu L, Dai X, Xiang C, Li L (2020) Clinical study of mesenchymal stem cell treatment for acute respiratory distress syndrome induced by epidemic influenza A (H7N9) infection: a hint for COVID-19 treatment. Engineering (Beijing). https://doi.org/10.1016/j.eng.2020.02.006
Article
PubMed
PubMed Central
Google Scholar
Cheng K, Ibrahim A, Hensley MT, Shen D, Sun B, Middleton R, Liu W, Smith RR, Marbán E (2014) Relative roles of CD90 and c-kit to the regenerative efficacy of cardiosphere-derived cells in humans and in a mouse model of myocardial infarction. J Am Heart Assoc 3:e001260. https://doi.org/10.1161/JAHA.114.001260
CAS
Article
PubMed
PubMed Central
Google Scholar
ClinicalTrials.gov. CAP-1002 in Severe COVID-19 Disease. 2020; NCT04338347. Available at: https://clinicaltrials.gov/ct2/show/NCT04338347. Accessed 19 Apr 2020
de Couto G (2019) Macrophages in cardiac repair: environmental cues and therapeutic strategies. Exp Mol Med 51:1–10. https://doi.org/10.1038/s12276-019-0269-4
CAS
Article
PubMed
Google Scholar
de Couto G, Gallet R, Cambier L, Jaghatspanyan E, Makkar N, Dawkins JF, Berman BP, Marbán E (2017) Exosomal microRNA transfer into macrophages mediates cellular postconditioning. Circulation 136:200–214. https://doi.org/10.1161/circulationaha.116.024590
Article
PubMed
PubMed Central
Google Scholar
de Couto G, Liu W, Tseliou E, Sun B, Makkar N, Kanazawa H, Arditi M, Marbán E (2015) Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction. J Clin Invest 125:3147–3162. https://doi.org/10.1172/JCI81321
Article
PubMed
PubMed Central
Google Scholar
Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S (2000) A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res 87:E1–9. https://doi.org/10.1161/01.res.87.5.e1
CAS
Article
PubMed
Google Scholar
Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL (2001) Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 286:1754–1758. https://doi.org/10.1001/jama.286.14.1754
CAS
Article
PubMed
Google Scholar
Gallet R, Dawkins J, Valle J, Simsolo E, de Couto G, Middleton R, Tseliou E, Luthringer D, Kreke M, Smith RR, Marbán L, Ghaleh B, Marbán E (2017) Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction. Eur Heart J 38:201–211. https://doi.org/10.1093/eurheartj/ehw240
CAS
Article
PubMed
Google Scholar
Gallet R, de Couto G, Simsolo E, Valle J, Sun B, Liu W, Tseliou E, Zile MR, Marbán E (2016) Cardiosphere-derived cells reverse heart failure with preserved ejection fraction (HFpEF) in rats by decreasing fibrosis and inflammation. JACC Basic Transl Sci 1:14–28. https://doi.org/10.1016/j.jacbts.2016.01.003
Article
PubMed
PubMed Central
Google Scholar
Gori T, Lelieveld J, Münzel T (2020) Perspective: cardiovascular disease and the Covid-19 pandemic. Basic Res Cardiol 115:32. https://doi.org/10.1007/s00395-020-0792-4
CAS
Article
PubMed
PubMed Central
Google Scholar
Grens K. TheScientist (2020) The Lancet Retracts Cardiac Stem Cell Clinical Trial Paper. 2019. Available at: https://www.the-scientist.com/news-opinion/the-lancet-retracts-cardiac-stem-cell-clinical-trial-paper-65598. Accessed 19 Apr 2020
Grigorian-Shamagian L, Liu W, Fereydooni S, Middleton RC, Valle J, Cho JH, Marbán E (2017) Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats. Eur Heart J 38:2957–2967. https://doi.org/10.1093/eurheartj/ehx454
CAS
Article
PubMed
PubMed Central
Google Scholar
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J (2020) Cao B (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet 395:497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
CAS
Article
PubMed
Google Scholar
Leng Z, Zhu R, Hou W, Feng Y, Yang Y, Han Q, Shan G, Meng F, Du D, Wang S, Fan J, Wang W, Deng L, Shi H, Li H, Hu Z, Zhang F, Gao J, Liu H, Li X, Zhao Y, Yin K, He X, Gao Z, Wang Y, Yang B, Jin R, Stambler I, Lim LW, Su H, Moskalev A, Cano A, Chakrabarti S, Min KJ, Ellison-Hughes G, Caruso C, Jin K, Zhao RC (2020) Transplantation of ACE2(-) mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia. Aging Dis 11:216–228. https://doi.org/10.14336/AD.2020.0228
Article
PubMed
PubMed Central
Google Scholar
Li TS, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, Matsushita N, Blusztajn A, Terrovitis J, Kusuoka H, Marbán L, Marbán E (2012) Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol 59:942–953. https://doi.org/10.1016/j.jacc.2011.11.029
Article
PubMed
PubMed Central
Google Scholar
Magagnoli J, Narendran S, Pereira F, Cummings T, Hardin JW, Sutton SS, Ambati J (2020) Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19. medRxiv. https://doi.org/10.1101/2020.04.16.20065920
Article
PubMed
PubMed Central
Google Scholar
Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E (2012) Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet 379:895–904. https://doi.org/10.1016/S0140-6736(12)60195-0
Article
PubMed
PubMed Central
Google Scholar
Marbán E (2018) A mechanistic roadmap for the clinical application of cardiac cell therapies. Nat Biomed Eng 2:353–361. https://doi.org/10.1038/s41551-018-0216-z
Article
PubMed
PubMed Central
Google Scholar
Marbán E (2018) The secret life of exosomes: what bees can teach us about next-generation therapeutics. J Am Coll Cardiol 71:193–200. https://doi.org/10.1016/j.jacc.2017.11.013
CAS
Article
PubMed
PubMed Central
Google Scholar
Maxeiner H, Mufti S, Krehbiehl N, Dülfer F, Helmig S, Schneider J, Böning A, Matejec R, Weigand MA, Schlüter KD, Wenzel S (2014) Interleukin-6 contributes to the paracrine effects of cardiospheres cultured from human, murine and rat hearts. J Cell Physiol 229:1681–1689. https://doi.org/10.1002/jcp.24613
CAS
Article
PubMed
Google Scholar
Middleton RC, Fournier M, Xu X, Marban E, Lewis MI (2017) Therapeutic benefits of intravenous cardiosphere-derived cell therapy in rats with pulmonary hypertension. PLoS ONE 12(8):e0183557. https://doi.org/10.1371/journal.pone.0183557
CAS
Article
PubMed
PubMed Central
Google Scholar
Nana-Leventaki E, Nana M, Poulianitis N, Sampaziotis D, Perrea D, Sanoudou D, Rontogianni D, Malliaras K (2019) Cardiosphere-derived cells attenuate inflammation, preserve systolic function, and prevent adverse remodeling in rat hearts with experimental autoimmune myocarditis. J Cardiovasc Pharmacol Ther 24:70–77. https://doi.org/10.1177/1074248418784287
CAS
Article
PubMed
Google Scholar
Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, Xie C, Ma K, Shang K, Wang W, Tian DS (2020) Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa248
Article
PubMed
PubMed Central
Google Scholar
Reich H, Tseliou E, de Couto G, Angert D, Valle J, Kubota Y, Luthringer D, Mirocha J, Sun B, Smith RR, Marbán L, Marbán E (2016) Repeated transplantation of allogeneic cardiosphere-derived cells boosts therapeutic benefits without immune sensitization in a rat model of myocardial infarction. J Heart Lung Transplant 35:1348–1357. https://doi.org/10.1016/j.healun.2016.05.008
Article
PubMed
Google Scholar
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, and the Northwell COVID-19 Research Consortium, Barnaby DP, Becker LB, Chelico JD, Cohen SL, Cookingham J, Coppa K, Diefenbach MA, Dominello AJ, Duer-Hefele J, Falzon L, Gitlin J, Hajizadeh N, Harvin TG, Hirschwerk DA, Kim EJ, Kozel ZM, Marrast LM, Mogavero JN, Osorio GA, Qiu M, Zanos TP (2020) Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. https://doi.org/10.1001/jama.2020.6775
Article
PubMed
PubMed Central
Google Scholar
Rizzo P, Vieceli Dalla Sega F, Fortini F, Marracino L, Rapezzi C, Ferrari R (2020) COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm? Basic Res Cardiol 115:31. https://doi.org/10.1007/s00395-020-0791-5
CAS
Article
PubMed
PubMed Central
Google Scholar
Rogers RG, Fournier M, Sanchez L, Ibrahim AG, Aminzadeh MA, Lewis MI, Marbán E (2019) Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice. JCI Insight. https://doi.org/10.1172/jci.insight.130202
Article
PubMed
PubMed Central
Google Scholar
Ruan Q, Yang K, Wang W, Jiang L, Song J (2020) Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. https://doi.org/10.1007/s00134-020-06028-z
Article
PubMed
PubMed Central
Google Scholar
Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR, Marbán E (2007) Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 115:896–908. https://doi.org/10.1161/CIRCULATIONAHA.106.655209
CAS
Article
PubMed
Google Scholar
Taylor M, Jefferies J, Byrne B, Lima J, Ambale-Venkatesh B, Ostovaneh MR, Makkar R, Goldstein B, Smith RR, Fudge J, Malliaras K, Fedor B, Rudy J, Pogoda JM, Marbán L, Ascheim DD, Marbán E, Victor RG (2019) Cardiac and skeletal muscle effects in the randomized HOPE-Duchenne trial. Neurology 92:e866–e878. https://doi.org/10.1212/WNL.0000000000006950
Article
PubMed
PubMed Central
Google Scholar
Vaninov N (2020) In the eye of the COVID-19 cytokine storm. Nat Rev Immunol. https://doi.org/10.1038/s41577-020-0305-6
Article
PubMed
PubMed Central
Google Scholar
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus-infected pneumonia in Wuhan, China. JAMA. https://doi.org/10.1001/jama.2020.1585
Article
PubMed
PubMed Central
Google Scholar
WHO (2020) Coronavirus disease (COVID-10) Pandemic. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed 28 Apr 2020
WHO (2019) WHO R&D Blueprint. COVID-19 Therapeutic Trial Synopsis. 2020. Available at: https://www.who.int/blueprint/priority-diseases/key-action/COVID-19_Treatment_Trial_Design_Master_Protocol_synopsis_Final_18022020.pdf. Accessed 19 Apr 2020
Wu Z, McGoogan JM (2020) Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. https://doi.org/10.1001/jama.2020.2648
Article
PubMed
PubMed Central
Google Scholar
Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, Wu Y, Zhang L, Yu Z, Fang M, Yu T, Wang Y, Pan S, Zou X, Yuan S, Shang Y (2020) Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. https://doi.org/10.1016/S2213-2600(20)30079-5
Article
PubMed
PubMed Central
Google Scholar
Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM, Lau SK, Anderson DE, Chan KS, Tan TY, Ng TY, Cui L, Said Z, Kurupatham L, Chen MI, Chan M, Vasoo S, Wang LF, Tan BH, Lin RTP, Lee VJM, Leo YS, Lye DC (2020) Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. https://doi.org/10.1001/jama.2020.3204
Article
PubMed
PubMed Central
Google Scholar