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Letter to the editor regarding “Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression”

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References

  1. de Las L, Hazas MC, Del Pozo-Acebo L, Hansen MS, Gil-Zamorano J, Mantilla- Escalante DC, Gómez-Coronado D, Marín F, Garcia-Ruiz A, Rasmussen JT, Dávalos A (2021) Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression. Eur J Nutr. https://doi.org/10.1007/s00394-021-02720-y (Epub ahead of print)

    Article  Google Scholar 

  2. Manca S, Upadhyaya B, Mutai E, Desaulniers AT, Cederberg RA, White BR, Zempleni J (2018) Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns. Sci Rep 8(1):11321. https://doi.org/10.1038/s41598-018-29780-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Betker JL, Angle BM, Graner MW, Anchordoquy TJ (2019) The potential of exosomes from cow milk for oral delivery. J Pharm Sci 108(4):1496–1505. https://doi.org/10.1016/j.xphs.2018.11.022

    Article  CAS  PubMed  Google Scholar 

  4. Samuel M, Fonseka P, Sanwlani R, Gangoda L, Chee SH, Keerthikumar S, Spurling A, Chitti SV, Zanker D, Ang CS, Atukorala I, Kang T, Shahi S, Marzan AL, Nedeva C, Vennin C, Lucas MC, Cheng L, Herrmann D, Pathan M, Chisanga D, Warren SC, Zhao K, Abraham N, Anand S, Boukouris S, Adda CG, Jiang L, Shekhar TM, Baschuk N, Hawkins CJ, Johnston AJ, Orian JM, Hoogenraad NJ, Poon IK, Hill AF, Jois M, Timpson P, Parker BS, Mathivanan S (2021) Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis. Nat Commun 12(1):3950. https://doi.org/10.1038/s41467-021-24273-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Reif S, Elbaum Shiff Y, Golan-Gerstl R (2019) Milk-derived exosomes (MDEs) have a different biological effect on normal fetal colon epithelial cells compared to colon tumor cells in a miRNA-dependent manner. J Transl Med 17(1):325. https://doi.org/10.1186/s12967-019-2072-3

    Article  PubMed  PubMed Central  Google Scholar 

  6. Aguilar-Lozano A, Baier S, Grove R, Shu J, Giraud D, Leiferman A, Mercer KE, Cui J, Badger TM, Adamec J, Andres A, Zempleni J (2018) Concentrations of purine metabolites are elevated in fluids from adults and infants and in livers from mice fed diets depleted of bovine milk exosomes and their RNA cargos. J Nutr 148(12):1886–1894. https://doi.org/10.1093/jn/nxy223

    Article  PubMed  PubMed Central  Google Scholar 

  7. Zhang C, Lu X, Hu J, Li P, Yan J, Ling X, Xiao J (2021) Bovine milk exosomes alleviate cardiac fibrosis via enhancing angiogenesis in vivo and in vitro. J Cardiovasc Transl Res. https://doi.org/10.1007/s12265-021-10174-0 (Epub ahead of print)

    Article  PubMed  Google Scholar 

  8. Melnik BC, Stremmel W, Weiskirchen R, John SM, Schmitz G (2021) Exosome-derived microRNAs of human milk and their effects on infant health and development. Biomolecules 11(6):851. https://doi.org/10.3390/biom11060851

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Stremmel W, Weiskirchen R, Melnik BC (2020) Milk exosomes prevent intestinal inflammation in a genetic mouse model of ulcerative colitis: a pilot experiment. Inflamm Intest Dis 5(3):117–123. https://doi.org/10.1159/000507626

    Article  PubMed  PubMed Central  Google Scholar 

  10. Melnik BC, Schmitz G (2019) Exosomes of pasteurized milk: potential pathogens of Western diseases. J Transl Med 17(1):3. https://doi.org/10.1186/s12967-018-1760-8

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Bodo C. Melnik.

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The authors declare that they have no conflict of interest.

Additional information

A reply to this letter can be read here: https://doi.org/10.1007/s00394-022-02816-z.

This letter refers to the original publication available here: https://doi.org/10.1007/s00394-021-02720-y.

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Melnik, B.C., Weiskirchen, R., Stremmel, W. et al. Letter to the editor regarding “Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression”. Eur J Nutr 61, 1695–1696 (2022). https://doi.org/10.1007/s00394-022-02817-y

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  • DOI: https://doi.org/10.1007/s00394-022-02817-y

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