Consumption of modern and traditional Moroccan dairy products and colorectal cancer risk: a large case control study

  • Khaoula El KinanyEmail author
  • Meimouna Mint Sidi Deoula
  • Zineb Hatime
  • Hanae Abir Boudouaya
  • Inge Huybrechts
  • Achraf El Asri
  • Abdelatif Benider
  • Mohammed Ahallat
  • Saïd Afqir
  • Nawfel Mellas
  • Mouna Khouchani
  • Karima El Rhazi
Original Contribution



The main objective of this study is to describe the association between the consumption of either traditional or modern dairy products or calcium intakes and the risk of colorectal cancer (CRC) in the adult Moroccan population.


A case–control study was conducted in five Moroccan hospital centers. The study was matched on sex, age (± 5 years) and center. Data were collected using validated food frequency questionnaire (FFQ) taking into account different types of Moroccan dairy products. Conditional logistic regression models were used to assess the association between dairy products consumption, calcium intakes and CRC risk subtypes. In all statistical tests, the significance level was set at 0.05.


Among 1453 cases and 1453 matched controls, 50.7% were women and 49.3% were men. Milk ORb 0.84, 95% CI 0.74–0.96 and yogurt ORb 0.74, 95% CI 0.64–0.86 were inversely associated with CRC risk. Similar inverse associations were observed for traditional dairy products namely Lben ORb 0.77, 95% CI 0.67–0.88, Raib ORb 0.86, 95% CI 0.76–0.96 and Jben ORb 0.77, 95% CI 0.67–0.88. The dairy calcium intake was inversely associated to CRC overall ORb 0.83, 95% CI 0.74–0.93.


Our study supports previous international evidence and suggests that individuals who have a high intake of either modern or traditional dairy products are at lower risk for CRC. These findings should be further confirmed by longitudinal data and studies investigating potential pathways involved.


Colorectal cancer Dairy products Prevention Morocco 



Many thanks to Lalla Salma Foundation, Prevention and Treatment of Cancers (FLSC) and Moroccan Society of Diseases of the Digestive System (SMMAD) for the financing of this study. Many thanks also to all contributors to this work in the Five University Hospitals centers; the directors of UHCs: Fez (Pr. Ait Taleb K), Casablanca (Pr. Afif My H); Rabat (Pr. Chefchaouni Al Mountacer C); Oujda (Pr Daoudi A); and Marrakech (Pr. Nejmi H). The heads of medical services and their teams: Casablanca (Pr. Benider A; Pr Alaoui R; Pr. Hliwa W; Pr. Badre W, Pr. Bendahou K, Pr. Karkouri M.), Rabat (Pr. Ahallat M; Pr. Errabih I; Pr. El Feydi AE; Pr. Chad B; Pr. Belkouchi A; Pr. Errihani H; Pr. Mrabti H; Pr. Znati K), Fez (Pr. Nejjari C; Pr Ibrahimi SA; Pr. El Abkari M; Pr. Mellas N; Pr. Chbani L; Pr. Benjelloun MC), Oujda (Pr. Ismaili N; Pr. Chraïbi M; Pr. Abda N, Pr. Abbaoui S) and Marrakech (Pr. Khouchani M; Pr. Samlani Z; Pr. Belbaraka R; Pr. Amine M).


Funding-source funder-id Lalla Salma Foundation, Prevention and Treatment of Cancers (FLSC), award-id N˚06/AP2013.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Khaoula El Kinany
    • 1
    • 2
    Email author
  • Meimouna Mint Sidi Deoula
    • 1
  • Zineb Hatime
    • 1
  • Hanae Abir Boudouaya
    • 1
  • Inge Huybrechts
    • 3
  • Achraf El Asri
    • 1
  • Abdelatif Benider
    • 4
  • Mohammed Ahallat
    • 5
  • Saïd Afqir
    • 6
  • Nawfel Mellas
    • 7
  • Mouna Khouchani
    • 8
  • Karima El Rhazi
    • 1
  1. 1.Department of Epidemiology and Public Health, Faculty of Medicine and pharmacy of FezSidi Mohamed Ben Abdellah UniversityFèsMorocco
  2. 2.Laboratory of Microbiology and Molecular Biology, Faculty of Science Dhar MehrazFèsMorocco
  3. 3.Nutritional Epidemiology Group (NEP)International Agency for Research on Cancer, World Health OrganizationLyonFrance
  4. 4.Mohammed VI Center for the Treatment of CancersIbn Rochd University Hospital Center CasablancaCasablancaMorocco
  5. 5.Department of Surgery CAvicenne University Hospital CenterRabatMorocco
  6. 6.Medical Oncology DepartmentMohammed VI University Hospital CenterOujdaMorocco
  7. 7.Medical Oncology DepartmentHassan II University Hospital CenterFèsMorocco
  8. 8.Oncology and Radiotherapy DepartmentMohammed VI University Hospital CenterMarrakechMorocco

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