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Effects of high-fat and low-fat diets rich in monounsaturated fatty acids on serum lipids, LDL size and indices of lipid peroxidation in healthy non-obese men and women when consumed under controlled conditions

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Abstract

Objective

To study the effects of the dietary fat content on cardiovascular disease risk factors in humans when the fatty acid composition and types of carbohydrates are kept constant.

Methods

A controlled dietary study in healthy volunteers with 2 dietary groups and a parallel design consisting of 2 dietary periods was conducted. First, participants received a 2-week wash-in diet rich in saturated fatty acids (SFA; 47% of total fatty acids) and were then randomly assigned to either a high-fat (40% of energy) or a low-fat diet (29% of energy) for 4 weeks. Both diets were isocaloric, rich in monounsaturated fatty acids (MUFA; 51% of total fatty acids) and had similar fatty acid and carbohydrate compositions.

Results

Compared to the wash-in diet, the high-fat and low-fat diets significantly lowered LDL-cholesterol (−0.34 and −0.41 mmol/l, respectively; P < 0.001 for time effect in RM-ANOVA), and HDL-cholesterol (−0.13 and −0.18 mmol/l, respectively; P < 0.001 for time), without any differences between the high-fat and low-fat diets (P = 0.112 and P = 0.085 for time × group interaction in RM-ANOVA, respectively). The size of the major LDL fraction, the LDL susceptibility to oxidation and the plasma concentrations of oxidized LDL (ox-LDL) were significantly reduced by both the high-fat and low-fat diet, again without significant differences between the diets. The ratio of ox-LDL/LDL-cholesterol, serum triacylglycerols and urinary F2-isoprostanes were not significantly affected by the diets.

Conclusion

A high-fat and a low-fat diet, both rich in MUFA, had similar effects on lipid-related cardiovascular disease risk factors in metabolically healthy men and women.

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Acknowledgments

This study was financially supported by the German Union for the Promotion of Oil- and Protein-containing Plants (UFOP).

Conflict of interest statement

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Authors and Affiliations

  1. Institute of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Endenicher Allee 11-13, 53115, Bonn, Germany

    Sarah Egert

  2. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Mario Kratz

  3. Institute of Clinical Chemistry and Laboratory Medicine, University of Muenster, Muenster, Germany

    Frank Kannenberg & Manfred Fobker

  4. Department of Human Nutrition, University of Applied Sciences, Muenster, Germany

    Ursel Wahrburg

Authors
  1. Sarah Egert
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  2. Mario Kratz
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  3. Frank Kannenberg
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  4. Manfred Fobker
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  5. Ursel Wahrburg
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Correspondence to Sarah Egert.

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Egert, S., Kratz, M., Kannenberg, F. et al. Effects of high-fat and low-fat diets rich in monounsaturated fatty acids on serum lipids, LDL size and indices of lipid peroxidation in healthy non-obese men and women when consumed under controlled conditions. Eur J Nutr 50, 71–79 (2011). https://doi.org/10.1007/s00394-010-0116-9

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  • DOI: https://doi.org/10.1007/s00394-010-0116-9

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