Editor,

I read the report on galectin 3 in heart failure by Lok et al. [1] with great interest. Lok et al. concluded that “Its prognostic value is independent of severity of HF, as assessed by NT-proBNP levels, and it may potentially be used in the management of such patients [1].” Based on the study of Lok et al. [1], galectin 3 seems to be a good biomarker. However, there are some facts on the galectin 3 determination to be concerned. First, the level of galectin 3 can be deviated in case with underlying concomitant thyroid disorder [2]. In addition, its increased level is also mentioned for many other neoplasms and inflammations [3]. In the report by Lok et al., these other possible concomitant disorders were not completely ruled out. Second, the laboratory quality control is an important issue to be discussed. Interference in sample collection and laboratory analysis should be carefully managed.