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Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

We sought to compare the effectiveness of a novel antibiotic irrigation device to the standard O-ring wound retractor in preventing surgical site infections (SSIs) following colorectal resections.

Methods

This single-arm clinical trial included patients undergoing colorectal resections utilizing the novel device. A retrospective cohort of patients undergoing the same procedures with the O-ring retractor was selected as the control group. The primary outcome assessed was SSI. Secondary outcomes assessed were overall complications, hospital length of stay (LOS), and 30-day readmission. A univariable and multivariable logistic regression model was built to evaluate the association between SSI as the outcome variable and the use of the novel device as the main independent variable. The model was adjusted for any confounding variables.

Results

Eighty-six novel device cases and 170 O-ring retractor cases were enrolled. There were no significant differences between the two groups in terms of demographics and preoperative comorbidities. Cases with the novel device had fewer Pfannenstiel incisions (1.2% vs. 14.6%, p < 0.001). There were no other significant differences in intraoperative variables. SSI rates were significantly lower in the novel device group (1.2% vs. 9.1%, p = 0.014). There were no other significant differences in postoperative complications. Multivariable logistic regression with backward elimination showed that the use of the novel device was significantly more effective against SSI by 92.5% compared to the use of the O-ring retractor.

Conclusion

The novel device may contribute to lower SSI rates compared to the O-ring retractor following colorectal resection.

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Data availability

The data underlying this article cannot be shared publicly due to the privacy of individuals who participated in the study. The data will be shared on reasonable request to the corresponding author.

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Funding

Yosef Nasseri received honorarium in the amount of $2400 from Prescient Surgical.

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Authors and Affiliations

  1. Surgery Group of Los Angeles, 8635 West 3rd Street, Suite 880W, Los Angeles, CA, 90048, USA

    Yosef Nasseri, Eli Kasheri, Ruoyan Zhu, Jason Cohen, Joshua Ellenhorn, Moshe Barnajian & Kimberly Oka

  2. Department of Colorectal Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Yosef Nasseri & Moshe Barnajian

  3. Department of Colorectal Surgery, Westchester Medical Center, Valhalla, NY, USA

    Abbas Smiley

  4. Department of General Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Jason Cohen

  5. Department of Surgical Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Joshua Ellenhorn

Authors
  1. Yosef Nasseri
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  2. Eli Kasheri
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  3. Ruoyan Zhu
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  4. Abbas Smiley
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  5. Jason Cohen
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  6. Joshua Ellenhorn
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  7. Moshe Barnajian
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  8. Kimberly Oka
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Contributions

Yosef Nasseri and Moshe Barnajian proposed the main research question. They, as well as Kimberly Oka, wrote the main manuscript text. Eli Kasheri, Ruoyan Zhu, and Kimberly Oka assisted with data collection for the study. Abbas Smiley and Kimberly Oka performed the statistical analyses and prepared Tables 1–4. All authors, especially Jason Cohen and Joshua Ellenhorn, reviewed the manuscript.

Corresponding author

Correspondence to Kimberly Oka.

Ethics declarations

Ethics approval

Approval was obtained from the Cedars-Sinai Institutional Review Board #Pro00039937.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Competing interests

Yosef Nasseri received honorarium in the amount of $2400 from Prescient Surgical.

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Nasseri, Y., Kasheri, E., Zhu, R. et al. Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection. Int J Colorectal Dis 38, 252 (2023). https://doi.org/10.1007/s00384-023-04542-2

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  • DOI: https://doi.org/10.1007/s00384-023-04542-2

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