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Epidemiology and survival outcomes in adenosquamous carcinoma: a population-based study

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background

The relationship between the location of the primary tumor and survival of adenosquamous carcinoma (ASC) remains poorly understood. This study aimed to evaluate the impact of primary tumor location on the survival outcome of patients with ASC.

Methods

Patients with ASC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database with ≥ 150 cases per tumor location. The Kaplan–Meier method was used to generate survival curves and differences among them were compared using the log-rank test. On the other hand, Cox proportional hazards models were used to evaluate factors that had independent predictive effects on cancer-specific survival (CSS).

Results

A total of 14,829 eligible patients with ASC were included in this study. Lung and bronchus ASC accounted for 51.1%, followed by the cervix uteri (17.0%), corpus uteri (13.9%), pancreas (4.9%), esophagus (3.1%), gallbladder (2.5%), stomach (2.2%), colon and rectum (2.0%), head and neck (1.8%), and breast ASC (1.3%). The 5-year CSS of breast, cervix uteri, colon and rectum, corpus uteri, esophagus, gallbladder, head and neck, lung and bronchus, pancreas, and stomach ASC was 76.9%, 66.0%, 34.8%, 72.9%, 12.0%, 10.8%, 45.0%, 24.7%, 4.3%, and 17.3%, respectively. COX analysis demonstrated that the primary tumor location was an independent prognostic factor for CSS. Besides, the breast, uterine corpus, and cervix as well as head and neck ASC were significantly associated with better prognosis, while pancreas and gallbladder ASC were significantly associated with poor CSS; stomach and colorectal were roughly the same as ASC prognosis.

Conclusion

Our study showed that the CSS of patients with ASC depends on the location of the primary tumor. Besides, tumor location is an important factor that should guide the use of chemotherapy and radiation.

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Data availability

All data generated or analyzed in this study was derived from the SEER database and can be obtained through the inclusion and exclusion criteria in this article.

References

  1. Shi X, Shao X, Zhang Y, Wu F, Tao Y (2020) Tumor location and survival outcomes in lung adenosquamous carcinoma: a propensity score matched analysis. Med Sci Monit 26:e922138

    PubMed  PubMed Central  Google Scholar 

  2. Filosso PL, Ruffini E, Asioli S, Giobbe R, Macri L, Bruna MC, Sandri A, Oliaro A (2011) Adenosquamous lung carcinomas: a histologic subtype with poor prognosis. Lung Cancer 74(1):25–29

    Article  Google Scholar 

  3. Li C, Lu H (2018) Adenosquamous carcinoma of the lung. Onco Targets Ther 11:4829–4835

    Article  Google Scholar 

  4. Wu X, Yu W, Petersen RH, Sheng H, Wang Y, Lv W, Hu J (2020) A competing risk nomogram predicting cause-specific mortality in patients with lung adenosquamous carcinoma. BMC Cancer 20(1):429

    Article  CAS  Google Scholar 

  5. Zhou SY, Qiao ZG, Li CL, Chen TB (2020) Primary adenosquamous carcinoma of the liver. Kaohsiung J Med Sci 36(10):857–858

    Article  Google Scholar 

  6. Murimwa G, Hester C, Mansour JC, Polanco PM, Porembka MR, Wang SC, Zeh HJ Jr, Yopp AC (2020) Comparative outcomes of adenosquamous carcinoma of the gallbladder: an analysis of the National Cancer Database. J Gastrointest Surg 25(7):1815–1827

    Article  Google Scholar 

  7. Ren S, Zhao R, Cui W, Qiu W, Guo K, Cao Y, Duan S, Wang Z, Chen R (2020) Computed tomography-based radiomics signature for the preoperative differentiation of pancreatic adenosquamous carcinoma from pancreatic ductal adenocarcinoma. Front Oncol 10:1618

    Article  Google Scholar 

  8. Nasseri Y, Cox B, Shen W, Zhu R, Stettler I, Cohen J, Artinyan A, Gangi A (2020) Adenosquamous carcinoma: an aggressive histologic sub-type of colon cancer with poor prognosis. Am J Surg 221(3):649–653

    Article  Google Scholar 

  9. Cheung R (2016) Analysis of SEER adenosquamous carcinoma data to identify cause specific survival predictors and socioeconomic disparities. Asian Pac J Cancer Prev 17(1):347–352

    Article  Google Scholar 

  10. Wang CB, Shahjehan F, Merchea A, Li Z, Bekaii-Saab TS, Grothey A, Colibaseanu DT, Kasi PM (2019) Impact of tumor location and variables associated with overall survival in patients with colorectal cancer: a Mayo Clinic Colon and Rectal Cancer Registry Study. Front Oncol 9:76

    Article  Google Scholar 

  11. Shindoh J, de Aretxabala X, Aloia TA, Roa JC, Roa I, Zimmitti G, Javle M, Conrad C, Maru DM, Aoki T (2015) Tumor location is a strong predictor of tumor progression and survival in T2 gallbladder cancer: an international multicenter study. Ann Surg 261(4):733–739

    Article  Google Scholar 

  12. Wu SG, Chen XT, Zhang WW, Sun JY, Li FY, He ZY, Pei XQ, Lin Q (2018) Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis. Expert Rev Gastroenterol Hepatol 12(2):209–214

    Article  CAS  Google Scholar 

  13. Wang J, Lian B, Ye L, Hu J, Song Y (2018) Clinicopathological characteristics and survival outcomes in adenosquamous carcinoma of the lung: a population-based study from the SEER database. Oncotarget 9(8):8133–8146

    Article  Google Scholar 

  14. Ge Y, Lin L, Ma X, Luo D, Shi L, Jiang M, Fan H, He Y, Yang L, Xu Z (2019) Adenosquamous carcinoma of the stomach: a population-based study from the SEER database. J Cancer 10(23):5705–5713

    Article  Google Scholar 

  15. Fang Y, Pu N, Zhang L, Wu W, Lou W (2019) Chemoradiotherapy is associated with improved survival for resected pancreatic adenosquamous carcinoma: a retrospective cohort study from the SEER database. Ann Transl Med 7(20):522

    Article  Google Scholar 

  16. Duorui N, Shi B, Zhang T, Chen C, Fang C, Yue Z, Wu P, Wu Z, Huang X, Li M (2020) The contemporary trend in worsening prognosis of pancreatic acinar cell carcinoma: a population-based study. PLoS ONE 15(12):e0243164

    Article  Google Scholar 

  17. Hu M, Zhang B, Xu J, Wang S, Zhao Y, Zhang L, Han B (2019) Clinical outcomes of different generations of EGFR tyrosine kinase inhibitors in advanced lung adenosquamous carcinoma. Mol Diagn Ther 23(6):773–779

    Article  CAS  Google Scholar 

  18. Lee RJ, Lin T, Lee SA, Lee KK, Christensen RE (2017) Importance of tumor extent in adenosquamous carcinoma of the head and neck: a retrospective cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol 124(2):114–120

    Article  Google Scholar 

  19. Qin BD, Jiao XD, Yuan LY, Liu K, Zang YS (2018) Adenosquamous carcinoma of the bile duct: a population-based study. Cancer Manag Res 10:439–446

    Article  Google Scholar 

  20. Mengoli MC, Longo FR, Fraggetta F, Cavazza A, Dubini A, Ali G, Guddo F, Gilioli E, Bogina G, Nannini N (2018) The 2015 World Health Organization Classification of lung tumors: new entities since the 2004 Classification. Pathologica 110(1):39–67

    CAS  PubMed  Google Scholar 

  21. Boyd CA, Benarroch-Gampel J, Sheffield KM, Cooksley CD, Riall TS (2012) 415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival. J Surg Res 174(1):12–19

    Article  Google Scholar 

  22. Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B, Liu XS (2020) TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res 48(W1):W509–W514

    Article  CAS  Google Scholar 

  23. Hoshimoto S, Hoshi S, Hishinuma S, Tomikawa M, Shirakawa H, Ozawa I, Wakamatsu S, Hoshi N, Hirabayashi K, Ogata Y (2017) Adenosquamous carcinoma in the biliary tract: association of the proliferative ability of the squamous component with its proportion and tumor progression. Scand J Gastroenterol 52(4):425–430

    Article  CAS  Google Scholar 

  24. Galic V, Herzog TJ, Lewin SN, Neugut AI, Burke WM, Lu YS, Hershman DL, Wright JD (2012) Prognostic significance of adenocarcinoma histology in women with cervical cancer. Gynecol Oncol 125(2):287–291

    Article  Google Scholar 

  25. Lai CH, Lau WY (2008) Gallbladder cancer–a comprehensive review. Surgeon 6(2):101–110

    Article  Google Scholar 

  26. Samuel S, Mukherjee S, Ammannagari N, Pokuri VK, Kuvshinoff B, Groman A, LeVea CM, Iyer R (2018) Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: a population-based study. PLoS ONE 13(6):e0198809

    Article  Google Scholar 

  27. Chen YY, Li AF, Huang KH, Lan YT, Chen MH, Chao Y, Lo SS, Wu CW, Shyr YM, Fang WL (2015) Adenosquamous carcinoma of the stomach and review of the literature. Pathol Oncol Res 21(3):547–551

    Article  Google Scholar 

  28. Schizas D, Kapsampelis P, Mylonas KM (2018) Adenosquamous carcinoma of the esophagus: a literature review. J Transl Int Med 6(2):70–73

    Article  Google Scholar 

  29. Toumi O, Hamida B, Njima M, Bouchrika A, Ammar H, Daldoul A, Zaied S, Ben Jabra S, Gupta R, Noomen F (2018) Adenosquamous carcinoma of the right colon: a case report and review of the literature. Int J Surg Case Rep 50:119–121

    Article  Google Scholar 

  30. Chen H, Shen C, Yin R, Yin Y, Chen J, Han L, Zhang B, Chen Z, Chen J (2015) Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma. World J Surg Oncol 13:136

    Article  Google Scholar 

  31. Evans M, Liu Y, Chen C, Steuer C, Cassidy R III, Landry J, Higgins K, Beitler JJ, Willingham F, Owonikoko TK (2017) Adenosquamous carcinoma of the esophagus: an NCDB-based investigation on comparative features and overall survival in a rare tumor. Oncology 93(5):336–342

    Article  Google Scholar 

  32. Katz MH, Taylor TH, Al-Refaie WB, Hanna MH, Imagawa DK, Anton-Culver H, Zell JA (2011) Adenosquamous versus adenocarcinoma of the pancreas: a population-based outcomes analysis. J Gastrointest Surg 15(1):165–174

    Article  Google Scholar 

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Authors and Affiliations

  1. School of Basic Medical Sciences, Chongqing Three Gorges Medical College, Chongqing, 404120, China

    Chuang Cheng, Wei Xiong, Zhongquan Shi & Hui Tan

  2. Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing, 404120, China

    Chuang Cheng, Wei Xiong, Zhongquan Shi & Hui Tan

  3. Department of Gastrointestinal Surgery, Chongqing University Three Gorges Hospital, Chongqing, 404120, China

    Zan Luo

Authors
  1. Chuang Cheng
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Contributions

Chuang Cheng conceived and designed the study; Zan Luo and Wei Xiong performed the analysis; Hui Tan and Zhongquan Shi prepared the figures and tables. All authors analyzed the results, wrote the main manuscript, and reviewed the manuscript.

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Correspondence to Hui Tan.

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The authors declare no competing interests.

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Cheng, C., Luo, Z., Xiong, W. et al. Epidemiology and survival outcomes in adenosquamous carcinoma: a population-based study. Int J Colorectal Dis 37, 1581–1592 (2022). https://doi.org/10.1007/s00384-022-04198-4

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  • DOI: https://doi.org/10.1007/s00384-022-04198-4

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