Skip to main content

Advertisement

SpringerLink
Log in

Adenosquamous Carcinoma of the Stomach and Review of the Literature

  • Research
  • Published:
Pathology & Oncology Research

Abstract

Adenosquamous carcinoma of the stomach is a very rare disease, consisting of less than 0.4 % of all stomach cancer. From 1991 to 2013, a total of 2800 patients received gastrectomy for gastric cancer at Taipei Veterans General hospital. Among them, seven patients (0.25 %) diagnosed as adenosquamous carcinoma were enrolled. The clinicopathologic characteristics and prognosis were analyzed. The mean age of the seven patients was 62.3 years-old. There were 5 males and 2 females. Six patients were stage III disease and one patient was stage IV disease. Four patients finally died of gastric cancer. Only one patient had no recurrence until death. Among the seven patients, adenocarcinoma component comprises the majority of the metastatic lymph node in 6 patients (85.7 %). The only one patient with major squamous cell carcinoma component in metastatic lymph node had no tumor recurrence till death. Adenosquamous carcinoma of stomach is a rare disease and is associated with a poor prognosis. The component of adenocarcinoma and squamous cell carcinoma in the metastatic lymph node may influence the prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Mori E, Watanabe A, Maekawa S et al (2000) Adenosquamous carcinoma of the remnant stomach: report of a case. Surg Today 30:643–646

    Article  CAS  PubMed  Google Scholar 

  2. Toyota N, Minagi S, Takeuchi T et al (1996) Adenosquamous carcinoma of the stomach associated with separate early gastric cancer (type IIc). J Gastroenterol 31:105–108

    Article  CAS  PubMed  Google Scholar 

  3. Tohma T, Yamamoto Y, Seki Y et al (2009) Weekly paclitaxel therapy is effective for gastric adenosquamous carcinoma: a case report. Hepatogastroenterology 56:568–570

    CAS  PubMed  Google Scholar 

  4. Samejima Y, Mizuno T, Sasakawa M et al (1974) A case report of early gastric adenoacanthoma and brief review of its literature. I To Cho 9:783–788 (in Japanese)

    Google Scholar 

  5. Watanabe Y, Nakamura N, Iwasaki N et al (1976) Early gastric adenoacanthoma of superficial spreading type diagnosed by gastroscopy, reported of a case. I To Cho 11:347–352 (in Japanese)

    Google Scholar 

  6. Hirai S, Koyama S, Ebihara T et al (1986) Two cases of the gastric adenosquamous cell carcinoma diagnosed by gastroscopic biopsy. Shokaki Naishikyo 28:3139–3145 (in Japanese)

    Google Scholar 

  7. Horikawa M, Miyashiro N, Nakatani M et al (1987) A case of early gastric adenosquamous carcinoma. Gan No Rinsho 33:305–310 (in Japanese)

    CAS  PubMed  Google Scholar 

  8. Johzaki H, Murayama H, Maekawa T et al (1988) A case of small squamous cell carcinoma with a grading of Ila + IIc, an early gastric cancer type. Gan No Rinsho 34:1025–1030 (in Japanese)

    CAS  PubMed  Google Scholar 

  9. Yasuda K, Daibo M, Urabe M et al (1991) A case of early gastric adenosquamous carcinoma. Shokaki Naishikyo No Shinpo 38:335–338 (in Japanese)

    Google Scholar 

  10. Nishidoi H, Ishiguro M, Kudoh H et al (1993) A case of early gastric adenosquamous carcinoma (type lie). Nippon Rinsho Geka Igakkai Zasshi 54:430 (in Japanese)

    Google Scholar 

  11. Yoshida K, Manabe T, Tsunoda T et al (1996) Early gastric cancer of adenosquamous carcinoma type: report of a case and review of literature. Jpn J Clin Oncol 26:252–257

    Article  CAS  PubMed  Google Scholar 

  12. Faria GR, Eloy C, Preto JR et al (2010) Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report. J Med Case Rep 4:351–5

  13. Saito S, Hosoya Y, Morishima K et al (2012) A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: a clinically aggressive tumor. J Dig Dis 13:407–413

    Article  CAS  PubMed  Google Scholar 

  14. Sobin L, Gospodarowicz M, Wittekind C (eds) (2009) TNM classification of malignant tumours (UICC International Union Against Cancer), 7th edn. New York, Wiley-Blackwell

    Google Scholar 

Download references

Acknowledgment

This research was supported by a grant from the Division of Experimental Surgery of the Department of Surgery and Taipei Veterans General Hospital (V103C-135).

Conflict of Interest

All authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan

    Yin-Yin Chen, Kuo-Hung Huang, Chew-Wun Wu, Yi-Ming Shyr & Wen-Liang Fang

  2. Department of Pathology, Taipei Veterans General Hospital, Taipei City, Taiwan

    Anna Fen-Yau Li

  3. Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei City, Taiwan

    Yuan-Tzu Lan

  4. Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan

    Ming-Huang Chen & Yee Chao

  5. School of Medicine, National Yang-Ming University, Taipei City, Taiwan

    Yin-Yin Chen, Anna Fen-Yau Li, Kuo-Hung Huang, Yuan-Tzu Lan, Ming-Huang Chen, Yee Chao, Su-Shun Lo, Chew-Wun Wu, Yi-Ming Shyr & Wen-Liang Fang

  6. Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei City, Taiwan

    Kuo-Hung Huang

  7. National Yang-Ming University Hospital, Yilan City, Taiwan

    Su-Shun Lo

Authors
  1. Yin-Yin Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna Fen-Yau Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kuo-Hung Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yuan-Tzu Lan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ming-Huang Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yee Chao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Su-Shun Lo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Chew-Wun Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yi-Ming Shyr
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Wen-Liang Fang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wen-Liang Fang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, YY., Li, A.FY., Huang, KH. et al. Adenosquamous Carcinoma of the Stomach and Review of the Literature. Pathol. Oncol. Res. 21, 547–551 (2015). https://doi.org/10.1007/s12253-014-9890-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-014-9890-7

Keywords

Search

Navigation