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The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Evidence on risk factors for postoperative recurrence in patients with colorectal cancer (CRC) confined to pathological stage I is limited. Therefore, this study aimed to identify the risk factors for recurrence in patients with stage I CRC.

Methods

Data on clinicopathological factors and blood tests of patients diagnosed with pathological stage I CRC at Hiroshima University Hospital between April 1, 2010, and December 31, 2018, were retrospectively obtained. The statistical significance between the clinical factors and postoperative recurrence was also investigated.

Results

A total of 244 patients were included. The median observation period was 45 months. There were 17 patients (6.6%) with a postoperative recurrence (8 local and 9 distant recurrences). In the log-lank test, rectal cancer (p = 0.004), pT2 (p = 0.020) and organ/space surgical site infection (SSI) (p = 0.008) were significantly associated with postoperative recurrence. In a multivariate analysis, rectal cancer (hazard ratio [HR] 3.678, 95% confidence interval [CI] 1.184–11.425, p = 0.024) and organ/space SSI (HR 3.137, 95% CI 1.013–9.713, p = 0.047) were independently associated with a higher recurrence rate. Among 18 patients with organ/space SSI, 4 recurrences occurred, all of which were distant metastases.

Conclusion

Organ/space SSI significantly affects the postoperative recurrence in patients with stage I CRC.

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Acknowledgments

We would like to thank Editage (www.editage.com) for English language editing.

Availability of data and material

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical & Health Science, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Shintaro Akabane, Hiroyuki Egi, Yuji Takakura, Masatoshi Kochi, Kazuhiro Taguchi, Ikki Nakashima, Yusuke Sumi, Koki Sato, Hisaaki Yoshinaka & Hideki Ohdan

  2. Department of Surgery, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure-City, Hiroshima, Japan

    Haruki Sada

  3. Center for Medical Education School of Medicine, Hiroshima University, Higashihiroshima, Hiroshima, Japan

    Minoru Hattori

Authors
  1. Shintaro Akabane
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  2. Hiroyuki Egi
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  3. Yuji Takakura
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  4. Haruki Sada
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  5. Masatoshi Kochi
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  6. Kazuhiro Taguchi
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  7. Ikki Nakashima
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  8. Yusuke Sumi
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  9. Koki Sato
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  10. Hisaaki Yoshinaka
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  11. Minoru Hattori
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  12. Hideki Ohdan
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Contributions

Akabane, Egi, Sada, and Ohdan were responsible for the conception and design of this study. Akabane wrote the manuscript and literature search. Egi and Takakura reviewed and edited the manuscript. Sada, Taguchi, Nakashima, Sumi, Sato, and Yoshinaka participated in the data acquisition. Akabane, Egi, Takakura, and Kochi treated and observed the patient. Akabane and Hattori performed the statistical analysis. All of the authors read and approved the final manuscript.

Corresponding author

Correspondence to Hiroyuki Egi.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

All research was approved by the Ethics Committees of Hiroshima University.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

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Patients signed informed consent regarding publishing their data.

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Akabane, S., Egi, H., Takakura, Y. et al. The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence. Int J Colorectal Dis 35, 1689–1694 (2020). https://doi.org/10.1007/s00384-020-03643-6

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  • DOI: https://doi.org/10.1007/s00384-020-03643-6

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