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Long-term outcomes after treatment for T1 colorectal carcinoma

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Long-term outcomes of patients with T1 colorectal carcinoma (CRC) treated by endoscopic resection (ER) or surgical resection are unclear in relation to the curative criteria in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines. The aim of this study was to retrospectively compare the long-term outcomes among patients with T1 CRC in relation to the treatment methods.

Methods

We examined 322 T1 CRC cases treated between January 1992 and August 2008 at Hiroshima University Hospital. Patients who did not meet the curative criteria in the JSCCR guidelines were defined as “non-endoscopically curable” and classified into three groups: underwent ER alone (group A: 45 patients), underwent additional surgery after ER (group B: 106 patients), and underwent surgical resection alone (group C: 92 patients).

Results

Of the 322 T1 CRC patients, 79 were categorized as endoscopically curable and 243 as non-endoscopically curable. Among the endoscopically curable T1 CRC patients, recurrence and 5-year OS rates were 0 and 94.2 %, respectively. In groups A, B, and C, recurrence rates were 4.4, 6.6, and 4.3 %, and OS rates were 85.6, 95.1, and 96.3 %, respectively (p < 0.05). Local recurrence or distant/lymph node metastasis was observed in 13 patients (group A: 2; group B: 7; group C: 4). Death due to primary CRC occurred in six patients (group B: 4; group C: 2).

Conclusion

Long-term outcomes support the curative criteria according to the JSCCR guidelines. ER for T1 CRC did not worsen clinical outcomes in cases that required additional surgical resection.

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Acknowledgments

The authors thank Professor Fumio Shimamoto at the Faculty of Human Culture and Science, Prefectural University of Hiroshima for advice on diagnosis of T1 CRC according to pathology.

Author contributions

NA, SO, and ST contributed to the study concept and design, statistical analysis and interpretation of data, and drafting of the manuscript. NA, YN, YT, KS, NH, HE, TH, and HO contributed to the acquisition of data. KA gave advice on diagnosis of T1 CRC according to pathology. All the authors participated in the critical revision of the article for important intellectual content and final approval of the article.

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Authors and Affiliations

  1. Department of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

    Naoki Asayama, Yuki Ninomiya, Yuzuru Tamaru, Kenjiro Shigita, Nana Hayashi & Kazuaki Chayama

  2. Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan

    Shiro Oka & Shinji Tanaka

  3. Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    Hiroyuki Egi, Takao Hinoi & Hideki Ohdan

  4. Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan

    Koji Arihiro

Authors
  1. Naoki Asayama
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  2. Shiro Oka
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  3. Shinji Tanaka
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  4. Yuki Ninomiya
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  5. Yuzuru Tamaru
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  7. Nana Hayashi
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  8. Hiroyuki Egi
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  9. Takao Hinoi
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  11. Koji Arihiro
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  12. Kazuaki Chayama
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Corresponding author

Correspondence to Shiro Oka.

Ethics declarations

The study protocol was approved by the Ethics Committee of Hiroshima University and was in keeping with the guidelines of the relevant government agency. All patients gave their informed consent before all procedures.

Conflict of interest

The authors declare that they have no competing interests.

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None

Additional information

Category

Colorectal neoplasia.

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Asayama, N., Oka, S., Tanaka, S. et al. Long-term outcomes after treatment for T1 colorectal carcinoma. Int J Colorectal Dis 31, 571–578 (2016). https://doi.org/10.1007/s00384-015-2473-6

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  • DOI: https://doi.org/10.1007/s00384-015-2473-6

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