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E-cadherin (CDH1) gene promoter polymorphism and the risk of colorectal cancer

A meta-analysis

  • Original Article
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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Objective

Published data on the relationship between E-cadherin (CDH1) gene promoter polymorphisms and colorectal cancer (CRC) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was carried out.

Methods

In this meta-analysis, we evaluated reported studies of associations between polymorphisms of CDH1 gene promoter −160 C > A and −347 G > GA site, and CRC risk using fixed-effects model and random-effects model.

Results

We found decreased CRC risk among subjects carrying CDH1 −160AA (odds ratio [OR] = 0.86, 95 percent confidence interval [95% CI]: 0.75–0.98) and CA + AA (OR = 0.92, 95% CI: 0.87–0.98), using 4,652/4,428 cases/controls and 7,866/7,689 cases/controls from ten studies, respectively. We found a protective effect of the CDH1 −160CA + AA polymorphisms for CRC in distal site tumor population and population-based control in stratified analysis. We found a protective effect of the CDH1 −160AA and CA + AA polymorphisms for CRC in European and American population (OR = 0.87, 95% CI: 0.76–0.99 and OR = 0.91, 95% CI: 0.85–0.98, respectively). We observed that the CDH1 −347 G/GA + GA/GA carrier had an increased risk of CRC, the summary OR was 1.33 (95% CI: 1.08–1.62).

Conclusions

Data indicated that certain CDH1 gene promoter −160 C > A and −347 G > GA variants might affect the susceptibility of CRC. Recommendations for further studies include pooling of individual data to facilitate evaluation of multigenic effects and detailed analysis of effect modification by environmental and lifestyle factors.

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Acknowledgements

We thank Dr. Jacqueline Miranda de Lima for collaboration and availability to share his papers for this present meta-analysis.

Conflicts of interest

No potential conflicts of interest are disclosed.

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Authors and Affiliations

  1. Henan Center for Disease Control and Prevention, No. 105 of East Nongye Road, Zhengdong New Area, 450016, Zhengzhou, China

    Yadong Wang, Li Li, Haiyu Wang, Congke Zhang & Xiangqun Xia

  2. Mechanical Engineering and Biomedical Engineering Program, University of South Carolina, Columbia, MO, 29208, USA

    Yadong Wang

  3. Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, 450001, China

    Haiyan Yang

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  1. Yadong Wang
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  3. Li Li
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Correspondence to Yadong Wang.

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Y. Wang and H. Yang contributed equally to this work.

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Wang, Y., Yang, H., Li, L. et al. E-cadherin (CDH1) gene promoter polymorphism and the risk of colorectal cancer. Int J Colorectal Dis 27, 151–158 (2012). https://doi.org/10.1007/s00384-011-1320-7

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