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Interaction between CTLA4 gene and IBD5 locus in Hungarian Crohn’s disease patients

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Backgrounds and aims

The IGR2198a_1 and IGR2096a_1 variants of the IBD5 region were found to be associated with Crohn’s disease (CD) in the Hungarian population, while IGR2230a_1 does not seem to confer risk for the disease. In the present study, our aim was to investigate the statistical interaction of these three IBD5 polymorphisms with the +49 A/G substitution within the cytotoxic T lymphocyte antigen-4 (CTLA4) gene, detected previously as neutral gene variant in Hungarian IBD patients.

Methods

A total of 305 unrelated subjects with CD and 310 healthy controls were genotyped with PCR-RFLP methods.

Results

In contrast with single gene effects, after genotype stratification, the IGR2198a_1 C and IGR2096a_1 T variants were found to confer susceptibility only in subjects with CTLA4 +49 AA genotype (P = 0.008; OR = 1.86 and P = 0.016; OR = 1.74, respectively), for IGR2230a_1 no such effect on disease risk could be demonstrated.

Conclusion

Analysis of specific genotype combinations unfolded a possible association between the CTLA4 +49 A/G substitution and two of the observed IBD5 variants with respect to disease risk.

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Acknowledgements

This work was supported by the Grant of Hungarian Scientific Research Foundation, No. OTKA T 73430. The authors wish to thank Judit Oksai and Edit Papp for their excellent technical assistance.

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Authors and Affiliations

  1. Department of Medical Genetics, University of Pécs, Pécs, Szigeti út 12, H-7624, Hungary

    Veronika Csöngei, Luca Járomi, Enikő Sáfrány, Csilla Sipeky, Lili Magyari, Noémi Polgár, Judit Bene, Eszter Baricza & Béla Melegh

  2. 1st Department of Internal Medicine, University of Pécs, Pécs, Hungary

    Patrícia Sarlós

  3. Department of Medicine and Gastroenterology, Markusovszky Hospital, Szombathely, Hungary

    Lilla Lakner

  4. Department of Pulmonology, Robert Koch Hospital, Edelény, Hungary

    Melinda Szabó

  5. Faculty of Economics, University of Pécs, Pécs, Hungary

    Gábor Rappai

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  1. Veronika Csöngei
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  2. Luca Járomi
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  3. Enikő Sáfrány
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Correspondence to Béla Melegh.

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Csöngei, V., Járomi, L., Sáfrány, E. et al. Interaction between CTLA4 gene and IBD5 locus in Hungarian Crohn’s disease patients. Int J Colorectal Dis 26, 1119–1125 (2011). https://doi.org/10.1007/s00384-011-1202-z

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