Abstract
Purpose
The objective of our study was to analyze the health economic impact of ferucarbotran-enhanced magnetic resonance imaging (MRI) in the diagnosis of hepatic colorectal cancer metastases based on observed changes in medical management.
Materials and methods
A decision tree simulating a patient’s medical management was designed, comparing two scenarios: contrast-enhanced spiral computed tomography-based vs ferucarbotran-enhanced MRI-based (Resovist®, Bayer Schering Pharma AG, Germany) diagnosis. A clinical trial in patients with presumed liver metastases (n = 36) provided data on clinical decisions regarding the medical management options in relation to diagnostic outcomes: resection, chemotherapy, or best supportive care. A “gold standard” was established afterward, combining all the available clinical, imaging, laboratory, and pathology findings. A multidisciplinary panel formed by a hepatologist, a liver surgeon, and an interventional radiologist decided on the recommended medical management for each patient. Costs of medical resources associated with each management option (all expressed in Euro) were obtained from the public health insurance (average European values). Life expectancies for the different options were obtained from literature.
Results
Despite an initial extra cost of €338, a significant net saving of €1,443 was obtained with ferucarbotran-enhanced MRI mainly because of avoiding unnecessary surgery. There was no significant difference in the predicted life expectancy between both arms, despite the large difference in medical decision.
Conclusion
In this comparative medical decision analysis, it was shown that ferucarbotran-enhanced MRI has the potential to improve medical management and save health care costs.
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Notes
“Gold standard” is the term used by the authors of Lencioni et al. [10]. For this reason, we apply this term as well. The scope of this “gold standard” is what is usually termed “Standard of Truth.”
References
Adam R, Lucidi V, Bismuth H (2004) Hepatic colorectal metastases: methods of improving resectability. Surg Clin North Am 84(2):659–671, Apr
Annemans L, Vanoverbeke N, Martin C. Cost of metastatic colorectal cancer (MCRC) in France and the UK: an incidence based approach. Paper presented at the 10th International Congress on Anti-cancer Treatment, Paris, France, Jan. 31–Feb. 3, 2000
Annemans L. Economic evaluation of oral chemotherapy in metastatic colorectal cancer. Oral presentation at the EAHP Congress, Amsterdam, March 22, 2001
Beard SM, Holmes M, Price C, Majeed AW (2000) Hepatic resection for colorectal liver metastases: a cost-effectiveness analysis. Ann Surg 232(6):763–776, Dec
Doubilet P, Begg CB, Weinstein MC, Braun P, McNeil BJ (1985) Probabilistic sensitivity analysis using Monte Carlo simulation. Med Dec Making 5(2):155–177
Drummond M, Stoddard M, Torrance G (1987) Economic evaluation of health care. Oxford Univ. Press, New York
Gazelle GS, Hunink MG, Kuntz KM, McMahon PM, Halpern EF, Beinfeld M, Lester JS, Tanabe KK, Weinstein MC (2003) Cost-effectiveness of hepatic metastasectomy in patients with metastatic colorectal carcinoma: a state-transition Monte Carlo decision analysis. Ann Surg 237(4):544–555, Apr
Helmberger T, Semelka R (2001) New contrast agents for imaging the liver. Magn Reson Imaging Clin N Am 9:745–766
Lencioni R, DellaPina C, Bruix J, Majno P, Grazioli L, Morana G, Filippone A, Laghi A, Bartolozzi C (2005) Clinical management of hepatic malignancies: ferucarbotran-enhanced magnetic resonance imaging versus contrast-enhanced spiral computed tomography. Dig Dis Sci 50(3):533–537, Mar
Lencioni R, Cioni D, Crocetti L, Della Pina C, Bartolozzi C (2004) Magnetic resonance imaging of liver tumors. J Hepatol 40(1):162–171, Jan
Miller DK, Homan SM (1994) Determining transition probabilities: confusion and suggestions. Med Decis Making 14(1):52–58, Jan–March
Mori K, Scheidler J, Helmberger T, Holzknecht N, Schauer R, Schirren CA, Bittmann I, Dugas M, Reiser M (2002) Detection of malignant hepatic lesions before orthotopic liver transplantation: accuracy of ferumoxides-enhanced MR imaging. Am J Roentgenol 179:1045–1051
Penna C, Nordlinger B (2003) Surgery and local treatments of liver metastases from colorectal cancer: how to improve results. Scand J Surg 92(1):90–96
Schultz JF, Bell JD, Goldstein RM, Kuhn JA, McCarty TM (1999) Hepatic tumor imaging using iron oxide MRI: comparison with computed tomography, clinical impact, and cost analysis. Ann Surg Oncol 6(7):691–698, Oct–Nov
Simmonds PC, Primrose JN, Colquitt JL, Garden OJ, Poston GJ, Rees M (2006) Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer 94(7):982–999, Apr 10
Acknowledgment
This research project was supported by an unrestricted grant from Bayer Schering Pharma AG.
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Annemans, L., Lencioni, R., Warie, H. et al. Health economic evaluation of ferucarbotran-enhanced MRI in the diagnosis of liver metastases in colorectal cancer patients. Int J Colorectal Dis 23, 77–83 (2008). https://doi.org/10.1007/s00384-007-0350-7
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DOI: https://doi.org/10.1007/s00384-007-0350-7