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Liver biopsy for hepatoblastoma: a single institution’s experience

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Abstract

Background/purpose

Hepatoblastoma diagnoses require liver biopsies. We aimed to investigate factors affecting the success of liver biopsy for hepatoblastoma diagnoses.

Methods

Data from patients with hepatoblastoma, including their demographic and clinical data, biopsy procedure information, pathologic diagnoses and subclassification, and surgical complications, were retrospectively reviewed.

Results

Of 153 patients who underwent liver biopsy, 28, 93, and 31 underwent computed tomography-guided, digital subtraction angiography-guided, and ultrasound-guided percutaneous biopsies, respectively, and one underwent a laparoscopic liver biopsy. One patient developed postoperative bleeding requiring a blood transfusion. The median number of specimens collected was 3. One-hundred and forty-four (94.1%) patients’ HB diagnoses were confirmed through biopsies, and 96 (62.7%) patients’ HB diagnoses were subclassified. Seven surgeons and eight interventional radiologists performed the biopsies. The diagnostic success rate did not correlate with the biopsy technique or the specialist who performed the biopsy. Significantly more specimens were biopsied from the patients whose diagnoses were subclassified (3.34 ± 1.08) than from those whose diagnoses were not subclassified (2.81 ± 0.79). Surgeons tended to collect more specimens than the interventional radiologists.

Conclusion

Percutaneous liver biopsy is safe and effective for diagnosing hepatoblastoma, and its complication rate is very low. Collecting >3 pieces of tissue is preferred.

Level of evidence

III.

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Abbreviations

AFP:

Alpha fetoprotein

CT:

Computed tomography

DSA:

Digital subtraction angiography

HB:

Hepatoblastoma

PRETEXT:

Pre-treatment extent of tumor

References

  1. Czauderna P, Garnier H (2018) Hepatoblastoma: current understanding, recent advances, and controversies. F1000 Res 7:53. https://doi.org/10.12688/f1000research.12239.1

    Article  Google Scholar 

  2. Ranganathan S, Lopez-Terrada D, Alaggio R (2019) Hepatoblastoma and pediatric hepatocellular carcinoma: an update. Pediatr Dev Pathol. 23:79–95. https://doi.org/10.1177/1093526619875228

    Article  PubMed  Google Scholar 

  3. Darbari A, Sabin KM, Shapiro CN et al (2003) Epidemiology of primary hepatic malignancies in U.S. children. Hepatology 38(3):560–566. https://doi.org/10.1053/jhep.2003.50375

    Article  PubMed  Google Scholar 

  4. Yang T, Whitlock RS, Vasudevan SA (2019) Surgical management of hepatoblastoma and recent advances. Cancers (Basel) 11:12. https://doi.org/10.3390/cancers11121944

    Article  Google Scholar 

  5. Aronson DC, Czauderna P, Maibach R et al (2014) The treatment of hepatoblastoma: its evolution and the current status as per the SIOPEL trials. J Indian Assoc Pediatr Surg 19:201–207

    Article  Google Scholar 

  6. Perilongo G, Malogolowkin M, Feusner J (2012) Hepatoblastoma clinical research: lessons learned and future challenges. Pediatr Blood Cancer 59(5):818–821. https://doi.org/10.1002/pbc.24217

    Article  PubMed  Google Scholar 

  7. Lopez-Terrada D, Alaggio R, de Davila MT et al (2014) Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol 27(3):472–491. https://doi.org/10.1038/modpathol.2013.80

    Article  PubMed  Google Scholar 

  8. Matthew Hawkins C, Towbin AJ, Roebuck DJ et al (2018) Role of interventional radiology in managing pediatric liver tumors: part 2: percutaneous interventions. Pediatr Radiol 48(4):565–580. https://doi.org/10.1007/s00247-018-4072-5

    Article  CAS  PubMed  Google Scholar 

  9. Lipnik AJ, Brown DB (2015) Image-guided percutaneous abdominal mass biopsy: technical and clinical considerations. Radiol Clin North Am 53(5):1049–1059. https://doi.org/10.1016/j.rcl.2015.05.007

    Article  PubMed  Google Scholar 

  10. Weldon CB, Madenci AL, Tiao GM et al (2019) Evaluation of the diagnostic biopsy approach for children with hepatoblastoma: a report from the Children’s Oncology Group AHEP 0731 Liver Tumor Committee. J Pediatr Surg. https://doi.org/10.1016/j.jpedsurg.2019.05.004

    Article  PubMed  Google Scholar 

  11. Ilivitzki A, Abugazala M, Arkovitz M et al (2014) Ultrasound-guided core biopsy as the primary tool for tissue diagnosis in pediatric oncology. J Pediatr Hematol Oncol 36:333–336

    Article  Google Scholar 

  12. Campagna G, Rosenfeld E, Foster J et al (2018) Evolving biopsy techniques for the diagnosis of neuroblastoma in children. J Pediatr Surg 53(11):2235–2239. https://doi.org/10.1016/j.jpedsurg.2018.04.012

    Article  PubMed  Google Scholar 

  13. Sakamoto Y, Karashima R, Ida S et al (2015) Diagnostic laparoscopic biopsy for intraabdominal tumors. Surg Today 45(3):394–396. https://doi.org/10.1007/s00595-014-1027-9

    Article  PubMed  Google Scholar 

  14. Westheim BH, Stensen AB, Aagenæs I et al (2012) Evaluation of risk factors for bleeding after liver biopsy in children. J Pediatr Gastroenterol Nutr 55:82–87

    Article  Google Scholar 

  15. Wang H, Li F, Liu J et al (2014) Ultrasound-guided core needle biopsy in diagnosis of abdominal and pelvic neoplasm in pediatric patients. Pediatr Surg Int 30(1):31–37. https://doi.org/10.1007/s00383-013-3427-0

    Article  PubMed  Google Scholar 

  16. Govender P, Jonas MM, Alomari AI et al (2013) Sonography-guided percutaneous liver biopsies in children. AJR Am J Roentgenol 201(3):645–650. https://doi.org/10.2214/AJR.12.9802

    Article  PubMed  Google Scholar 

  17. Dezsofi A, Baumann U, Dhawan A et al (2015) Liver biopsy in children: position paper of the ESPGHAN hepatology committee. J Pediatr Gastroenterol Nutr 60(3):408–420. https://doi.org/10.1097/MPG.0000000000000632

    Article  PubMed  Google Scholar 

  18. Subramanian KS, Chikhale M, Barwad A et al (2019) Fine-needle aspiration cytology and cell block in diagnosis and subtyping of hepatoblastoma. Diagn Cytopathol 47(7):706–710. https://doi.org/10.1002/dc.24167

    Article  PubMed  Google Scholar 

  19. Vlajnic T, Brisse HJ, Aerts I et al (2017) Fine needle aspiration in the diagnosis and classification of hepatoblastoma: analysis of 21 new cases. Diagn Cytopathol 45(2):91–100. https://doi.org/10.1002/dc.23642

    Article  PubMed  Google Scholar 

  20. Pohar-Marinsek Z (2008) Difficulties in diagnosing small round cell tumours of childhood from fine needle aspiration cytology samples. Cytopathology 19(2):67–79. https://doi.org/10.1111/j.1365-2303.2008.00555.x

    Article  PubMed  Google Scholar 

  21. Garrett KM, Fuller CE, Santana VM et al (2005) Percutaneous biopsy of pediatric solid tumors. Cancer 104(3):644–652. https://doi.org/10.1002/cncr.21193

    Article  PubMed  Google Scholar 

  22. Sebire NJ, Roebuck DJ (2006) Pathological diagnosis of paediatric tumours from image-guided needle core biopsies: a systematic review. Pediatr Radiol 36(5):426–431. https://doi.org/10.1007/s00247-006-0123-4

    Article  PubMed  Google Scholar 

  23. Tanaka Y, Inoue T, Horie H (2013) International pediatric liver cancer pathological classification: current trend. Int J Clin Oncol 18(6):946–954. https://doi.org/10.1007/s10147-013-0624-8

    Article  PubMed  Google Scholar 

  24. Czaudernaa P, Lopez-Terradab D, Hiyamac E et al (2014) Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy. Curr Opin Pediatr 26:19–28. https://doi.org/10.1097/MOP.0000000000000046

    Article  CAS  Google Scholar 

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Author notes

  1. Manna Zheng and Jiahao Li contributed equally to this work.

Authors and Affiliations

  1. Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Tianhe District, Guangzhou, 510623, China

    Manna Zheng, Jiahao Li, Chao Hu, Tianbao Tan, Jiliang Yang, Jing Pan, Huiying Wu, Haibo Li, Lianwei Lu, Xiwen Chen, Xiaohong Zhang, Tao Xu, Yan Zou & Tianyou Yang

Authors
  1. Manna Zheng
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  2. Jiahao Li
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  3. Chao Hu
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  4. Tianbao Tan
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  5. Jiliang Yang
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  6. Jing Pan
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  7. Huiying Wu
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  8. Haibo Li
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  9. Lianwei Lu
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  10. Xiwen Chen
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  11. Xiaohong Zhang
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  12. Tao Xu
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  13. Yan Zou
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  14. Tianyou Yang
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Contributions

Study conception and design were performed by Tianyou Yang, Manna Zheng, Huiying Wu, Yan Zou. Material preparation, data collection were performed by Jiahao Li, Chao Hu, Tianbao Tan, Jiliang Yang, Jing Pan, Haibo Li, Lianwei Lu, Xiaohong Zhang, Tao Xu, and Xiwen Chen. Analysis and data interpretation were performed by Tianyou Yang, Jiahao Li. The manuscript was written by Manna Zheng and Jiahao Li, and revised by Yan Zou and Tianyou Yang. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Tianyou Yang.

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There is no conflict of interest.

Ethical approval

Ethical approval was waived by the local Ethics Committee of Guangzhou Women and Children’s Medical Center, Guangzhou Medical University in view of the retrospective nature of the study and all the procedures being performed were part of the routine care.

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Consent is not required because information is anonymized and the submission does not include images that may identify the person.

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Zheng, M., Li, J., Hu, C. et al. Liver biopsy for hepatoblastoma: a single institution’s experience. Pediatr Surg Int 36, 909–915 (2020). https://doi.org/10.1007/s00383-020-04702-3

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