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Anaplastic histology Wilms’ tumors registered to the Japan Wilms’ Tumor Study Group are less aggressive than that in the National Wilms’ Tumor Study 5

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Abstract

Purpose

To evaluate the clinical features and treatment results of anaplastic histology (AH) Wilms’ tumor (WT) patients registered in the Japan Wilms’ Tumor Study (JWiTS) group to elucidate the clinical characteristics of AH in the Japanese population.

Patients and methods

Of 344 WT patients who were enrolled in JWiTS between 1995 and 2013, 17 had AH. Treatment using the JWiTS protocols was similar to the fifth National Wilms’ Tumor Study 5 (NWTS-5) protocols. Clinical characteristics and mutation status of TP53 gene were evaluated and compared with those in NWST-5 study.

Results

AH incidences in JWiTS were 4.9 %, lower than that in NWTS-5. Seven tumors had focal AH and 10 had diffuse AH. Clinical stages of AH patients were stage I in seven, stage II in three, stage III in five, stage IV in one and unknown in one. Four-year event-free survival and overall survival rates were 90.9 and 86.7 %, respectively. Two patients with diffuse AH and none with focal AH had TP53 mutation.

Conclusion

Japanese patients presented with higher incidence, earlier stages and may have better outcomes than American patients, indicating a possible biological heterogeneity of AH WT. Further analysis is necessary to elucidate the different characteristic of AH WT between Japanese and American populations.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 63-8501, Japan

    Takaharu Oue

  2. Department of Pediatric Surgery, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

    Tsugumichi Koshinaga

  3. Division of Registration and Research for Childhood Cancer, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan

    Tetsuya Takimoto

  4. Department of Pathology, Keio University, Shinjyuku-ku, Tokyo, Japan

    Hajime Okita

  5. Department of Pathology, Kanagawa Children’s Medical Center, Yokohama, Kanagawa, Japan

    Yukichi Tanaka

  6. Department of Radiology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan

    Miwako Nozaki

  7. Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan

    Masayuki Haruta & Yasuhiko Kaneko

  8. Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan

    Masahiro Fukuzawa

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  1. Takaharu Oue
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  2. Tsugumichi Koshinaga
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  3. Tetsuya Takimoto
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  4. Hajime Okita
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  5. Yukichi Tanaka
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  6. Miwako Nozaki
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  7. Masayuki Haruta
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  8. Yasuhiko Kaneko
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  9. Masahiro Fukuzawa
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Consortia

Renal Tumor Committee of the Japanese Children’s Cancer Group

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Correspondence to Takaharu Oue.

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Oue, T., Koshinaga, T., Takimoto, T. et al. Anaplastic histology Wilms’ tumors registered to the Japan Wilms’ Tumor Study Group are less aggressive than that in the National Wilms’ Tumor Study 5. Pediatr Surg Int 32, 851–855 (2016). https://doi.org/10.1007/s00383-016-3929-7

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  • DOI: https://doi.org/10.1007/s00383-016-3929-7

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