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Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS Group

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Abstract

Purpose

In 1996, the Japan Wilms Tumor Study (JWiTS) group was founded to elucidate the efficacy and safety of the regimen established by the National Wilms Tumor Study (NWTS) group in the USA, and a multicenter cooperative study (JWiTS-1) was started in Japan. This report reviews the results of JWiTS-1.

Methods

A total of 307 patients with malignant renal tumor were enrolled in the JWiTS-1 study between 1996 and 2005. Central pathological diagnosis and follow-up data were available in 210 cases. The protocol regimens were similar to the NWTS-5 regimens. Clinical stage was classified according to the Japanese Staging System.

Results

Five-year overall survival (OS) rate was 91.1% for nephroblastoma, 72.9% for clear cell sarcoma of the kidney (CCSK), and 22.2% for rhabdoid tumor of the kidney (RTK). In the nephroblastoma patients, 5-year OS was 90.5% for stage I disease, 92.2% for stage II, 90.9% for stage III, 86.7% for stage IV, and 78.7% for stage V.

Conclusions

The OS of patients in the JWiTS-1 study were comparable with the results of other multicenter studies in the USA and Europe. The outcome for patients with nephroblastoma and CCSK was fair. In contrast, the cure rate for those with RTK was not satisfactory. New treatment strategies are needed for patients with RTK.

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Acknowledgments

We thank the investigators of the JWiTS and the many pathologists, surgeons, pediatricians, and radiation oncologists who managed the children enrolled on the JWiTS. This work was supported by a Grant-in-Aid for scientific research (no. 20390452) from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

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Authors and Affiliations

  1. Division of Pediatric Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Takaharu Oue & Masahiro Fukuzawa

  2. Department of Developmental Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan

    Hajime Okita

  3. Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1 Ooyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Hideo Mugishima & Motoaki Chin

  4. Pathology, Chiba Children’s Hospital, 579-1 Heta-cho, Midori-ku, Chiba, 266-0007, Japan

    Hiroshi Horie

  5. National Center for Child Health and Development & Tokiwa University, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan

    Jun-ichi Hata

  6. Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Masahiro Saito

  7. Department of Radiology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan

    Miwako Nozaki

  8. Department of Pediatrics, Kitazato University School of Medicine, 1-15-1 Kitazato, Sagamihara, Kanagawa, 228-8555, Japan

    Hisaya Nakadate

  9. Department of Pharmacoepidemiology, Kyoto University Graduate School of Medicine and Public Health, Yoshidakonoe-cho, Sakyoku, Kyoto, 606-8501, Japan

    Shiro Hinotsu

  10. Department of Pediatric Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Tsugumichi Koshinaga

  11. Research Institute for Clinical Oncology, Saitama Cancer Center, Komuro 818, Ina, Kitaadachi-gun, Saitama, 362-0806, Japan

    Yasuhiko Kaneko

  12. Department of Pediatric Surgery, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan

    Yoshihiro Kitano

  13. Department of Pathology, Kanagawa Children’s Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama, Kanagawa, 232-8555, Japan

    Yukichi Tanaka

Authors
  1. Takaharu Oue
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  2. Masahiro Fukuzawa
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  3. Hajime Okita
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  4. Hideo Mugishima
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  5. Hiroshi Horie
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  6. Jun-ichi Hata
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  7. Masahiro Saito
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  8. Miwako Nozaki
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  9. Motoaki Chin
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  10. Hisaya Nakadate
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  11. Shiro Hinotsu
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  12. Tsugumichi Koshinaga
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  13. Yasuhiko Kaneko
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  14. Yoshihiro Kitano
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  15. Yukichi Tanaka
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Japan Wilms Tumor Study (JWiTS) Group

Corresponding author

Correspondence to Takaharu Oue.

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Oue, T., Fukuzawa, M., Okita, H. et al. Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS Group. Pediatr Surg Int 25, 923–929 (2009). https://doi.org/10.1007/s00383-009-2449-0

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  • DOI: https://doi.org/10.1007/s00383-009-2449-0

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