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The composition of choroid plexus tumor research: a bibliometric analysis of the 100 most impactful studies to date

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Abstract

Purpose

Choroid plexus tumors (CPT) are relatively rare CNS tumors that primarily occur in children. They are classified as low-grade choroid plexus papilloma, including atypical ones, and high-grade choroid plexus carcinoma based on histological characteristics. There has been extensive academic research regarding these complex tumors. The goal of this work was to identify the 100 most-cited articles pertaining to CPTs in order to better understand the most impactful studies to date.

Methods

In August 2023, Elsevier’s Scopus database was searched for the 100 most-cited articles about CPT. To look for trends, articles were classified as either basic science or clinical, and the earliest 50 articles were separated from the latest 50 articles and then were compared. Various bibliometric parameters were summarized and compared using Pearson’s chi-square exact test and Wilcoxon rank sum test/Mann–Whitney U test.

Results

The 100 most-cited articles were published between 1955 and 2016 in 53 different scientific journals, originating from 16 distinct countries. Over 75% of the articles were clinical in nature, and overall mean (range) values were as follows: citation count 78.5 (42–371), citation rate per year 3.4 (0.9–12), number of authors 6.2 (1–28). Newer articles had statistically higher citation rate (P < 0.01) and number of authors (P < 0.01) compared to their older counterparts. Additionally, while there was no significant difference in article focus (P = 0.64), there was a difference in study design (P < 0.01).

Conclusion

This study used citation number as a surrogate for article impact and identified the 100 most-cited CPT articles. New mutational analyses have allowed for further subgrouping and positive trends in collaboration shine hope for improvement in treatment outcomes and long-term survival.

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References

  1. Thomas C, Soschinski P, Zwaig M, Oikonomopoulos S, Okonechnikov K, Pajtler KW, Sill M, Schweizer L, Koch A, Neumann J, Schüller U, Sahm F, Rauschenbach L, Keyvani K, Proescholdt M, Riemenschneider MJ, Segewiß J, Ruckert C, Grauer O, Monoranu CM, Lamszus K, Patrizi A, Kordes U, Siebert R, Kool M, Ragoussis J, Foulkes WD, Paulus W, Rivera B, Hasselblatt M (2021) The genetic landscape of choroid plexus tumors in children and adults. Neuro Oncol 23:650–660. https://doi.org/10.1093/neuonc/noaa267

    Article  CAS  PubMed  Google Scholar 

  2. Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan Jill S (2022) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2015–2019. Neuro Oncol 24:v1–v95. https://doi.org/10.1093/neuonc/noac202

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rickert CH, Paulus W (2001) Tumors of the choroid plexus. Microsc Res Tech 52:104–111. https://doi.org/10.1002/1097-0029(20010101)52:1%3c104::AID-JEMT12%3e3.0.CO;2-3

    Article  CAS  PubMed  Google Scholar 

  4. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23:1231–1251. https://doi.org/10.1093/neuonc/noab106

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Siegfried A, Morin S, Munzer C, Delisle MB, Gambart M, Puget S, Maurage CA, Miquel C, Dufour C, Leblond P, André N, Branger DF, Kanold J, Kemeny JL, Icher C, Vital A, Coste EU, Bertozzi AI (2017) A French retrospective study on clinical outcome in 102 choroid plexus tumors in children. J Neurooncol 135:151–160. https://doi.org/10.1007/s11060-017-2561-2

    Article  CAS  PubMed  Google Scholar 

  6. Thomas C, Sill M, Ruland V, Witten A, Hartung S, Kordes U, Jeibmann A, Beschorner R, Keyvani K, Bergmann M, Mittelbronn M, Pietsch T, Felsberg J, Monoranu CM, Varlet P, Hauser P, Olar A, Grundy RG, Wolff JE, Korshunov A, Jones DT, Bewerunge-Hudler M, Hovestadt V, von Deimling A, Pfister SM, Paulus W, Capper D, Hasselblatt M (2016) Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol 18:790–796. https://doi.org/10.1093/neuonc/nov322

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Merino DM, Shlien A, Villani A, Pienkowska M, Mack S, Ramaswamy V, Shih D, Tatevossian R, Novokmet A, Choufani S, Dvir R, Ben-Arush M, Harris BT, Hwang EI, Lulla R, Pfister SM, Achatz MI, Jabado N, Finlay JL, Weksberg R, Bouffet E, Hawkins C, Taylor MD, Tabori U, Ellison DW, Gilbertson RJ, Malkin D (2015) Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res 21:184–192. https://doi.org/10.1158/1078-0432.Ccr-14-1324

    Article  CAS  PubMed  Google Scholar 

  8. Thomas C, Ruland V, Kordes U, Hartung S, Capper D, Pietsch T, Gerß J, Wolff JE, Paulus W, Hasselblatt M (2015) Pediatric atypical choroid plexus papilloma reconsidered: increased mitotic activity is prognostic only in older children. Acta Neuropathol 129:925–927. https://doi.org/10.1007/s00401-015-1434-z

    Article  PubMed  Google Scholar 

  9. Bettegowda C, Adogwa O, Mehta V, Chaichana KL, Weingart J, Carson BS, Jallo GI, Ahn ES (2012) Treatment of choroid plexus tumors: a 20-year single institutional experience. J Neurosurg Pediatr 10:398–405. https://doi.org/10.3171/2012.8.Peds12132

    Article  PubMed  PubMed Central  Google Scholar 

  10. Safaee M, Oh MC, Sughrue ME, Delance AR, Bloch O, Sun M, Kaur G, Molinaro AM, Parsa AT (2013) The relative patient benefit of gross total resection in adult choroid plexus papillomas. J Clin Neurosci 20:808–812. https://doi.org/10.1016/j.jocn.2012.08.003

    Article  PubMed  Google Scholar 

  11. Lafay-Cousin L, Keene D, Carret AS, Fryer C, Brossard J, Crooks B, Eisenstat D, Johnston D, Larouche V, Silva M, Wilson B, Zelcer S, Bartels U, Bouffet E (2011) Choroid plexus tumors in children less than 36 months: the Canadian Pediatric Brain Tumor Consortium (CPBTC) experience. Childs Nerv Syst 27:259–264. https://doi.org/10.1007/s00381-010-1269-9

    Article  PubMed  Google Scholar 

  12. Wrede B, Hasselblatt M, Peters O, Thall PF, Kutluk T, Moghrabi A, Mahajan A, Rutkowski S, Diez B, Wang X, Pietsch T, Kortmann RD, Paulus W, Jeibmann A, Wolff JEA (2009) Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neurooncol 95:383–392. https://doi.org/10.1007/s11060-009-9936-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Wrede B, Liu P, Wolff JEA (2007) Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. J Neurooncol 85:345–351. https://doi.org/10.1007/s11060-007-9428-x

    Article  PubMed  Google Scholar 

  14. Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HG, Calicchio ML, Zeng E, Salisbury JL, Wechsler-Reya RJ, Lehtinen MK, Schüller U, Zhao H (2016) Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol 18:418–430. https://doi.org/10.1038/ncb3327

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Tabori U, Shlien A, Baskin B, Levitt S, Ray P, Alon N, Hawkins C, Bouffet E, Pienkowska M, Lafay-Cousin L, Gozali A, Zhukova N, Shane L, Gonzalez I, Finlay J, Malkin D (2010) TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors. J Clin Oncol 28:1995–2001. https://doi.org/10.1200/jco.2009.26.8169

    Article  CAS  PubMed  Google Scholar 

  16. Falagas ME, Pitsouni EI, Malietzis GA, Pappas G (2008) Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. Faseb j 22:338–342. https://doi.org/10.1096/fj.07-9492LSF

    Article  CAS  PubMed  Google Scholar 

  17. Bergsagel DJ, Finegold MJ, Butel JS, Kupsky WJ, Garcea RL (1992) Dna sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. N Engl J Med 326:988–993. https://doi.org/10.1056/NEJM199204093261504

    Article  CAS  PubMed  Google Scholar 

  18. Duffner PK, Kun LE, Burger PC, Horowitz ME, Cohen ME, Sanford RA, Krischer JP, Mulhern RK, James HE, Rekate HL et al (1995) Postoperative chemotherapy and delayed radiation in infants and very young children with choroid plexus carcinomas. The Pediatric Oncology Group Pediatr Neurosurg 22:189–196. https://doi.org/10.1159/000120900

    Article  CAS  PubMed  Google Scholar 

  19. Wrede B, Liu P, Ater J, Wolff JEA (2005) Second surgery and the prognosis of choroid plexus carcinoma - results of a meta-analysis of individual cases. Anticancer Res 25:4429–4433

    PubMed  Google Scholar 

  20. Lafay-Cousin L, Mabbott DJ, Halliday W, Taylor MD, Tabori U, Kamaly-Asl ID, Kulkarni AV, Bartels U, Greenberg M, Bouffet E (2010) Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma. J Neurosurg Pediatr 5:615–621. https://doi.org/10.3171/2010.3.PEDS09354

    Article  PubMed  Google Scholar 

  21. Hasselblatt M, Böhm C, Tatenhorst L, Dinh V, Newrzella D, Keyvani K, Jeibmann A, Buerger H, Rickert CH, Paulus W (2006) Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. Am J Surg Pathol 30:66–74. https://doi.org/10.1097/01.pas.0000176430.88702.e0

    Article  PubMed  Google Scholar 

  22. Hasselblatt M, Mertsch S, Koos B, Rlesmeier B, Stegemann H, Jeibmann A, Tonim M, Schmitz N, Wrede B, Wolff JE, Zheng W, Paulus W (2009) TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion. Can Res 69:2219–2223. https://doi.org/10.1158/0008-5472.CAN-08-3176

    Article  CAS  Google Scholar 

  23. Rickert CH, Wiestler OD, Paulus W (2002) Chromosomal imbalances in choroid plexus tumors. Am J Pathol 160:1105–1113. https://doi.org/10.1016/S0002-9440(10)64931-0

    Article  PubMed  PubMed Central  Google Scholar 

  24. Wolff JEA, Sajedi M, Brant R, Coppes MJ, Egeler RM (2002) Choroid plexus tumours. Br J Cancer 87:1086–1091. https://doi.org/10.1038/sj.bjc.6600609

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Wolff JEA, Sajedi M, Coppes MJ, Anderson RA, Maarten Egeler R (1999) Radiation therapy and survival in choroid plexus carcinoma. Lancet 353:2126. https://doi.org/10.1016/S0140-6736(99)01744-4

    Article  CAS  PubMed  Google Scholar 

  26. Chow E, Jenkins JJ, Burger PC, Reardon DA, Langston JW, Sanford RA, Heideman RL, Kun LE, Merchant TE (1999) Malignant evolution of choroid plexus papilloma. Pediatr Neurosurg 31:127–130. https://doi.org/10.1159/000028847

    Article  CAS  PubMed  Google Scholar 

  27. Chow E, Reardon DA, Shah AB, Jenkins JJ, Langston J, Heideman RL, Sanford RA, Kun LE, Merchant TE (1999) Pediatric choroid plexus neoplasms. Int J Radiat Oncol Biol Phys 44:249–254. https://doi.org/10.1016/S0360-3016(98)00560-4

    Article  CAS  PubMed  Google Scholar 

  28. Jeibmann A, Hasselblatt M, Gerss J, Wrede B, Egensperger R, Beschorner R, Hans VHJ, Rickert CH, Wolff JE, Paulus W (2006) Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol 65:1069–1073. https://doi.org/10.1097/01.jnen.0000240464.26005.90

    Article  PubMed  Google Scholar 

  29. Paulus W, Jänisch W (1990) Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases. Acta Neuropathol 80:635–641. https://doi.org/10.1007/BF00307632

    Article  CAS  PubMed  Google Scholar 

  30. Lewis P (1967) Carcinoma of the choroid plexus. Brain 90:177–186. https://doi.org/10.1093/brain/90.1.177

    Article  CAS  PubMed  Google Scholar 

  31. Laurence KM (1979) The biology of choroid plexus papilloma in infancy and childhood. Acta Neurochir 50:79–90. https://doi.org/10.1007/BF01813553

    Article  CAS  PubMed  Google Scholar 

  32. Hawkins Iii JC (1980) Treatment of choroid plexus papillomas in children: a brief analysis of twenty years’ experience. Neurosurgery 6:380–384. https://doi.org/10.1227/00006123-198004000-00005

    Article  Google Scholar 

  33. Johnson DL (1989) Management of choroid plexus tumors in children. Pediatr Neurosci 15:195–206. https://doi.org/10.1159/000120468

    Article  CAS  PubMed  Google Scholar 

  34. Brinster RL, Chen HY, Messing A, van Dyke T, Levine AJ, Palmiter RD (1984) Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37:367–379. https://doi.org/10.1016/0092-8674(84)90367-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Lednicky JA, Garcea RL, Bergsagel DJ, Butel JS (1995) Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors. Virology 212:710–717. https://doi.org/10.1006/viro.1995.1529

    Article  CAS  PubMed  Google Scholar 

  36. Palmiter RD, Chen HY, Messing A, Brinster RL (1985) SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice. Nature 316:457–460. https://doi.org/10.1038/316457a0

    Article  ADS  CAS  PubMed  Google Scholar 

  37. Westworth DR, Dickinson PJ, Vernau W, Johnson EG, Bollen AW, Kass PH, Sturges BK, Vernau KM, Lecouteur RA, Higgins RJ (2008) Choroid plexus tumors in 56 dogs (1985–2007). J Vet Intern Med 22:1157–1165. https://doi.org/10.1111/j.1939-1676.2008.0170.x

    Article  CAS  PubMed  Google Scholar 

  38. Ribas JL, Mena H, Braund KG, Sesterhenn IA, Toivio-Kinnucan M (1989) A histologic and immunocytochemical study of choroid plexus tumors of the dog. Vet Pathol 26:55–64. https://doi.org/10.1177/030098588902600109

    Article  CAS  PubMed  Google Scholar 

  39. Gyure KA, Morrison AL (2000) Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. Mod Pathol 13:638–643. https://doi.org/10.1038/modpathol.3880111

    Article  CAS  PubMed  Google Scholar 

  40. Doglioni C, Dell’Orto P, Coggi G, Iuzzolino P, Bontempini L, Viale G (1987) Choroid plexus tumors. An immunocytochemical study with particular reference to the coexpression of intermediate filament proteins. Am J Pathol 127:519–529

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Miettinen M, Clark R, Virtanen I (1986) Intermediate filament proteins in choroid plexus and ependyma and their tumors. Am J Pathol 123:231–240

    CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

No individuals other than the listed co-authors contributed to this publication.

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Authors and Affiliations

  1. Department of Neurologic Surgery, Mayo Clinic, 200 1St St SW, Rochester, MN, 55905, USA

    Julian S. Rechberger & David J. Daniels

  2. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, 55905, USA

    Julian S. Rechberger & David J. Daniels

  3. Hopp Children’s Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany

    Leo F. Nonnenbroich

  4. Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), 69120, Heidelberg, Germany

    Leo F. Nonnenbroich

  5. Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, USA

    Erica A. Power

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Contributions

Conception and design: J.S.R., L.F.N., D.J.D. Drafting the article: J.S.R., L.F.N., E.A.P. Critically revising the article: D.J.D. Reviewed submitted version of manuscript: J.S.R., L.F.N., E.A.P., D.J.D. Approved the final version of the manuscript on behalf of all authors: J.S.R. Article supervision: D.J.D.

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Correspondence to David J. Daniels.

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Rechberger, J.S., Nonnenbroich, L.F., Power, E.A. et al. The composition of choroid plexus tumor research: a bibliometric analysis of the 100 most impactful studies to date. Childs Nerv Syst 40, 453–462 (2024). https://doi.org/10.1007/s00381-023-06157-y

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