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Choroid plexus tumors in children less than 36 months: the Canadian Pediatric Brain Tumor Consortium (CPBTC) experience

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Abstract

Background

Choroid plexus tumors (CPT) are rare pediatric tumors. A population-based study on choroid plexus carcinoma (CPC) and choroid plexus papilloma (CPP) was carried out to describe the incidence, demographic, and outcome data and to identify potential prognostic factors.

Methods

The CPT population from the Canadian databank of CNS tumor in children ≤36 months diagnosed between 1990 and 2005 was reviewed

Results

Out of the 579 reported cases of CNS tumors, 37 were CPT. The annual age-adjusted incidence rate was 0.22 + 0.12 (95% CI 0.16–0.28)/100,000 children <3 years. There were 21 (56.7%) CPP and 16 (43.3.5%) CPC. Twenty patients (54%) were males. Median age at diagnosis was 7 months(range 0–30). Ten patients(62.5%) with CPC and one with CPP were metastatic at diagnosis. Twenty patients with CPP (95%) had a complete resection, whereas 6/16 CPC (37.5%) achieved a resection >90%. Fourteen CPC patients received adjuvant chemotherapy. None of the 37 patients received adjuvant radiation. At completion of survey, all CPP and five CPC were alive. Median survival time for CPC patients was 15 months (0–120). One death was related to intraoperative hemorrhage, another to chemotherapy-induced toxicity, and one to secondary AML. Age at diagnosis, degree of resection and metastatic status were not significant prognostic factors for CPC.

Conclusion

By contrast to CPC, CPP have an excellent prognosis following surgery alone. Survival of CPC remains poor. However, these data may suggest adjuvant chemotherapy can alter the aggressive natural history of CPC. As with other rare CNS tumors, international collaboration is required to identify optimal therapy.

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References

  1. Jänisch W, Staneczek W (1989) Primary tumors of the choroid plexus. Frequency, localization and age. Zentralbl Allg Pathol 135:235–240

    PubMed  Google Scholar 

  2. Greenberg ML (1999) Chemotherapy of choroid plexus carcinoma. Childs Nerv Syst 15:571–577

    Article  CAS  PubMed  Google Scholar 

  3. Wolff JE, Sajedi M, Brant R, Coppes MJ, Egeler RM (2002) Choroid plexus tumours. Br J Cancer 87:1086–1091

    Article  CAS  PubMed  Google Scholar 

  4. Keene D, Lafay-Cousin L, Carret AS, Crooks B, Eisenstat D, Fryer C, Johnston D, Larouche V, Mograbi A, Silva M, Wilson B, Zelcer S, Bouffet E (2008) The Canadian Pediatric Brain Tumor Consortium national survey of CNS tumors in children under 3 years of age. Neuro Oncol 10:416

    Google Scholar 

  5. Annual Demographic Statistics (2005) Statistics Canada Catalogue no. 91-213-XIB

  6. Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, Sanford RA, Mulhern RK, James HE, Freeman CR et al (1993) Postoperative chemotherapy and delayed radiation in children less than 3 years of age with malignant brain tumors. N Engl J Med 328:1725–1731

    Article  CAS  PubMed  Google Scholar 

  7. Wrede B, Hasselblatt M, Peters O, Thall PF, Kutluk T, Moghrabi A, Mahajan A, Rutkowski S, Diez B, Wang X, Pietsch T, Kortmann RD, Paulus W, Jeibmann A, Wolff JE (2009) Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neurooncol 95:383–392

    Article  CAS  PubMed  Google Scholar 

  8. Lafay-Cousin L, Mabbott DJ, Halliday W, Taylor MD, Tabori U, Kamaly-Asl ID, Kulkarni AV, Bartels U, Greenberg M, Bouffet E (2010) Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma. J Neurosurg Pediatr 5:615–621

    Article  PubMed  Google Scholar 

  9. Walker DA, Perilongo G, Punt JAG, Taylor RE (2004) Brain and spinal tumors of childhood, 1st edn. London E Arnold

  10. Boyd MC, Steinbok P (1987) Choroid plexus tumors: problems in diagnosis and management. J Neurosurg 66:800–805

    Article  CAS  PubMed  Google Scholar 

  11. Allen J, Wisoff J, Helson L, Pearce J, Arenson E (1992) Choroid plexus carcinoma-responses to chemotherapy alone in newly diagnosed young children. J Neurooncol 12:69–74

    Article  CAS  PubMed  Google Scholar 

  12. Larouche V, Huang A, Bartels X, Bouffet E (2007) Pediatr Blood Cancer 49:1074–1082

    Article  PubMed  Google Scholar 

  13. Duffner PK, Kun LE, Burger PC, Horowitz ME, Cohen ME, Sanford RA, Krischer JP, Mulhern RK, James HE, Rekate HL, Friedmean H, the Pediatric Oncology Group et al (1995) Postoperative chemotherapy and delayed radiation in infants and very young children with choroid plexus carcinomas. Pediatr Neurosurg 22:189–196

    Article  CAS  PubMed  Google Scholar 

  14. McEvoy AW, Harding BN, Phipps KP, Ellison DW, Elsmore AJ, Thompson D, Harkness W, Hayward RD (2000) Management of choroid plexus tumours in children: 20 years experience at a single neurosurgical centre. Pediatr Neurosurg 32:192–199

    Article  CAS  PubMed  Google Scholar 

  15. Pencalet P, Sainte-Rose C, Lellouch-Tubiana A, Kalifa C, Brunelle F, Sgouros S, Meyer P, Cinalli G, Zerah M, Pierre-Kahn A, Renier D (1998) Papillomas and carcinomas of the choroid plexus in children. J Neurosurg 88:521–528

    Article  CAS  PubMed  Google Scholar 

  16. Strojan P, Popović M, Surlan K, Jereb B (2004) Choroid plexus tumors: a review of 28-year experience. Neoplasma 51:306–312

    CAS  PubMed  Google Scholar 

  17. Ellenbogen RG, Winston KR, Kupsky WJ (1998) Tumors of the choroid plexus in children. Neurosurgery 42:470–475

    Article  Google Scholar 

  18. Berger C, Thiesse P, Lellouch-Tubiana A, Kalifa C, Pierre-Kahn A, Bouffet E (1989) Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurgery 25:327–335

    Google Scholar 

  19. Packer RJ, Perilongo G, Johnson D, Sutton LN, Vezina G, Zimmerman RA, Ryan J, Reaman G, Schut L (1992) Choroid plexus carcinoma of childhood. Cancer 69:580–585, Review

    Article  CAS  PubMed  Google Scholar 

  20. Wrede B, Liu P, Ater J, Wolff JE (2005) Second surgery and the prognosis of choroid plexus carcinoma—results of a meta-analysis of individual cases. Anticancer Res 25:4429–4433

    PubMed  Google Scholar 

  21. Wrede B, Liu P, Wolff JE (2007) Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. J Neurooncol 85:345–351

    Article  PubMed  Google Scholar 

  22. Fitzpatrick LK, Aronson LJ, Cohen KJ (2002) Is there a requirement for adjuvant therapy for choroid plexus carcinoma that has been completely resected? J Neurooncol 57:123–126

    Article  PubMed  Google Scholar 

  23. Chow E, Reardon DA, Shah AB, Jenkins JJ, Langston J, Heideman RL, Sanford RA, Kun LE, Merchant TE (1999) Pediatric choroid plexus neoplasms. Int J Radiat Oncol Biol Phys 44:249–254

    Article  CAS  PubMed  Google Scholar 

  24. Kamaly-Asl ID, Bouffet E, Halliday W, Drake JM, Rutka JT, Dirks PB, Kulkarni AV, Taylor MD (2005) Neoadjuvant chemotherapy reduces operative haemorrhage and improves resection for choroid plexus carcinomas. Childs Nerv Syst 21:852

    Google Scholar 

  25. Mazloom A, Wolff JE, Paulino AC (2009) The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. Int J Radiat Oncol Biol Phys 75:S510

    Google Scholar 

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Authors and Affiliations

  1. Pediatric Hematology Oncology and Bone marrow transplantation program, Alberta Children’s Hospital, 2888 Shaganappi Trail NW, Calgary, T3B 6A8, AB, Canada

    Lucie Lafay-Cousin

  2. Division of Pediatric Oncology, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada

    Daniel Keene & Donna Johnston

  3. Department of Pediatric Hematology Oncology, Hospital Ste Justine, Montreal, QC, Canada

    Anne-Sophie Carret

  4. Division of Oncology/Hematology/BMT, BC Children’s Hospital and BC Women’s Hospital & Health Centre, Vancouver, BC, Canada

    Chris Fryer

  5. Pediatric Oncology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada

    Josee Brossard

  6. Department of Pediatric Hematology Oncology, IWK Health Centre, Halifax, NS, Canada

    Bruce Crooks

  7. Pediatric Hematology/Oncology, CancerCare Manitoba, Winnipeg, MB, Canada

    David Eisenstat

  8. Pediatric Hematology/Oncology, Centre Hospitalier Universitaire de Quebec, Quebec, QC, Canada

    Valerie Larouche

  9. Pediatric Hematology Oncology, Kingston General Hospital, Kingston, ON, Canada

    Marianna Silva

  10. Department of Pediatric Hematology Oncology, Stollery Children’s Hospital, Edmonton, AB, Canada

    Beverly Wilson

  11. Department of Pediatric Hematology Oncology, London Health Science Centre, London, ON, Canada

    Shayna Zelcer

  12. Pediatric Brain Tumor Program, Division of Pediatric Hematology Oncology, Hospital for Sick Children, Toronto, ON, Canada

    Ute Bartels & Eric Bouffet

Authors
  1. Lucie Lafay-Cousin
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  2. Daniel Keene
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  3. Anne-Sophie Carret
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  4. Chris Fryer
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  5. Josee Brossard
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  6. Bruce Crooks
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  7. David Eisenstat
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  8. Donna Johnston
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  9. Valerie Larouche
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  10. Marianna Silva
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  11. Beverly Wilson
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  12. Shayna Zelcer
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  13. Ute Bartels
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  14. Eric Bouffet
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Corresponding author

Correspondence to Lucie Lafay-Cousin.

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Lafay-Cousin, L., Keene, D., Carret, AS. et al. Choroid plexus tumors in children less than 36 months: the Canadian Pediatric Brain Tumor Consortium (CPBTC) experience. Childs Nerv Syst 27, 259–264 (2011). https://doi.org/10.1007/s00381-010-1269-9

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  • DOI: https://doi.org/10.1007/s00381-010-1269-9

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